Splanchnic insulin metabolism in obesity. Influence of body fat distribution.
Open accessAbstract
The effects of obesity and body fat distribution on splanchnic insulin metabolism and the relationship to peripheral insulin sensitivity were assessed in 6 nonobese and 16 obese premenopausal women. When compared with the nonobese women, obese women had significantly greater prehepatic production and portal vein levels of insulin both basally and following glucose stimulation. This increase correlated with the degree of adiposity but not with waist-to-hip girth ratio (WHR). WHR, however, correlated inversely with the hepatic extraction fraction and directly with the posthepatic delivery of insulin. The latter correlated with the degree of peripheral insulinemia. The decline in hepatic insulin extraction with increasing WHR also correlated with the accompanying diminution in peripheral insulin sensitivity. Increasing adiposity is thus associated with insulin hypersecretion. The pronounced hyperinsulinemia of upper body fat localization, however, is due to an additional defect in hepatic insulin extraction. This defect is closely allied with the decline in peripheral insulin sensitivity.
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Self-citation
- Authors
- Peiris, A. N., Mueller, R. A., Smith, G. A., Struve, M. F., & Kissebah, A. H.
- Affiliations
- Froedtert Hospital (US)
- ORCID
- Peiris, A N
- Venue
- Journal of Clinical Investigation
- Published
- 1986-12-01
- Volume
- 78
- Issue
- 6
- Pages
- 1648-1657
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC423938
- OpenAlex
- W2163235578
- Cited by
- 346
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 8
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- National Institutes of Health (RR00058)
- National Heart, Lung, and Blood Institute (HL32060)
- National Center for Research Resources (RR00058)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obesity, body fat distribution, waist-to-hip ratio, hepatic insulin extraction, insulin hypersecretion, peripheral insulin sensitivity, premenopausal women
- MeSH terms
- Adipose Tissue, Adult, C-Peptide, Female, Glucose, Humans, Insulin, Kinetics, Liver, Obesity, Viscera
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