Cited by 346Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Open access
Peiris, A N, Mueller, R A, Smith, G A, Struve, M F, Kissebah, A H·1986·Journal of Clinical Investigation

Abstract

The effects of obesity and body fat distribution on splanchnic insulin metabolism and the relationship to peripheral insulin sensitivity were assessed in 6 nonobese and 16 obese premenopausal women. When compared with the nonobese women, obese women had significantly greater prehepatic production and portal vein levels of insulin both basally and following glucose stimulation. This increase correlated with the degree of adiposity but not with waist-to-hip girth ratio (WHR). WHR, however, correlated inversely with the hepatic extraction fraction and directly with the posthepatic delivery of insulin. The latter correlated with the degree of peripheral insulinemia. The decline in hepatic insulin extraction with increasing WHR also correlated with the accompanying diminution in peripheral insulin sensitivity. Increasing adiposity is thus associated with insulin hypersecretion. The pronounced hyperinsulinemia of upper body fat localization, however, is due to an additional defect in hepatic insulin extraction. This defect is closely allied with the decline in peripheral insulin sensitivity.

Integrity signals

Registry

Crossref · 10.1172/jci112758

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Peiris, A. N., Mueller, R. A., Smith, G. A., Struve, M. F., & Kissebah, A. H.
Affiliations
Froedtert Hospital (US)
Venue
Journal of Clinical Investigation
Published
1986-12-01
Volume
78
Issue
6
Pages
1648-1657
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2163235578
Cited by
346
References
49
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 8
FWCI
9.67
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Yale University
  • National Institutes of Health (RR00058)
  • National Heart, Lung, and Blood Institute (HL32060)
  • National Center for Research Resources (RR00058)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
obesity, body fat distribution, waist-to-hip ratio, hepatic insulin extraction, insulin hypersecretion, peripheral insulin sensitivity, premenopausal women
MeSH terms
Adipose Tissue, Adult, C-Peptide, Female, Glucose, Humans, Insulin, Kinetics, Liver, Obesity, Viscera

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review