Importance of obesity for the metabolic abnormalities associated with an abdominal fat distribution
Abstract
Obese people with a high waist/hip ratio (W/H ratio) have an increased risk for cardiovascular disease. The present study was designed to separately analyze the importance of obesity and the regional fat distribution for the metabolic risk factors. Blood pressure, glucose tolerance, insulin, and plasma lipid levels were studied in lean and obese postmenopausal women with a high or low W/H ratio. The individuals within each group were carefully matched for age, lean body mass, and body fat. The risk factors associated with a high W/H ratio (elevated blood pressure, blood lipids, and glucose levels) were found in the obese but not in the lean women. Furthermore, lean women with a high W/H ratio tended to have a lower metabolic risk factor profile than obese women with a low W/H ratio. These findings document the importance of obesity in expressing the metabolic risk factors for cardiovascular disease associated with a high W/H ratio.
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Women with peripheral fat distribution (WHR ≤ 0.85) irrespective of BMI had a higher glucose disposal rate (16 mg/kg LBM/min), similar to the non-diabetic women with PCOS in the present study.
“Women with peripheral fat distribution (WHR ≤ 0.85) irrespective of BMI had a higher glucose disposal rate (16 mg/kg LBM/min), similar to the non-diabetic women with PCOS in the present study (Landin et al., 1989).”
From Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution (2020) · cites this paper as Landin et al., 1989
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Growth hormone-deficient adults are insulin-resistant
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- Authors
- Landin, K., Krotkiewski, M., & Smith, U.
- Affiliations
- Sahlgrenska University Hospital (SE)
- ORCID
- Smith, Ulf
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1989-06
- Volume
- 38
- Issue
- 6
- Pages
- 572-576
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2045320031
- Cited by
- 91
- References
- 22
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 2 · 2016: 2 · 2015: 1 · 2012: 2
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obesity, waist-to-hip ratio, abdominal fat distribution, metabolic risk factors, cardiovascular risk, postmenopausal women, blood pressure, glucose tolerance, insulin, plasma lipids, regional fat distribution
- MeSH terms
- Abdomen, Adipose Tissue, Anthropometry, Blood Pressure, Body Composition, Cardiovascular Diseases, Cholesterol, Fatty Acids, Nonesterified, Female, Glucose Tolerance Test, Humans, Insulin, Middle Aged, Muscles, Obesity, Risk Factors, Triglycerides
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