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Cited by 238Cardiovascular and exercise physiologyRespiratory Support and MechanismsChronic Obstructive Pulmonary Disease (COPD) Research

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Smaller lungs in women affect exercise hyperpnea

McClaran, Steven R., Harms, Craig A., Pegelow, David F., Dempsey, Jerome A.·1998·Journal of Applied Physiology
DOI 10.1152/jappl.1998.84.6.1872
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Abstract

We subjected 29 healthy young women (age: 27 ± 1 yr) with a wide range of fitness levels [maximal oxygen uptake (V˙o 2 max): 57 ± 6 ml ⋅ kg−1⋅ min−1; 35–70 ml ⋅ kg−1⋅ min−1] to a progressive treadmill running test. Our subjects had significantly smaller lung volumes and lower maximal expiratory flow rates, irrespective of fitness level, compared with predicted values for age- and height-matched men. The higher maximal workload in highly fit (V˙o 2 max> 57 ml ⋅ kg−1⋅ min−1, n = 14) vs. less-fit (V˙o 2 max< 56 ml ⋅ kg−1⋅ min−1, n = 15) women caused a higher maximal ventilation (V˙e) with increased tidal volume (Vt) and breathing frequency (f b) at comparable maximal Vt/vital capacity (VC). More expiratory flow limitation (EFL; 22 ± 4% of Vt) was also observed during heavy exercise in highly fit vs. less-fit women, causing higher end-expiratory and end-inspiratory lung volumes and greater usage of their maximum available ventilatory reserves. HeO 2(79% He-21% O 2) vs. room air exercise trials were compared (with screens added to equalize external apparatus resistance). HeO 2 increased maximal expiratory flow rates (20–38%) throughout the range of VC, which significantly reduced EFL during heavy exercise. When EFL was reduced with HeO 2, Vt, f b, andV˙e (+16 ± 2 l/min) were significantly increased during maximal exercise. However, in the absence of EFL (during room air exercise), HeO 2 had no effect onV˙e. We conclude that smaller lung volumes and maximal flow rates for women in general, and especially highly fit women, caused increased prevalence of EFL during heavy exercise, a relative hyperinflation, an increased reliance on f b, and a greater encroachment on the ventilatory “reserve.” Consequently, Vt andV˙e are mechanically constrained during maximal exercise in many fit women because the demand for high expiratory flow rates encroaches on the airways’ maximum flow-volume envelope.

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Crossref · 10.1152/jappl.1998.84.6.1872

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Citations

Cites

Research works printed but not linked: 5

  1. Åstrand P. O., 1963, Acta Paediatr. Suppl., 147, 5
  2. Crapo R. O., 1982, Clin. Respir. Physiol., 18, 419
  3. Jones N. L., 1985, Am. Rev. Respir. Dis., 131, 700
  4. Knudson R. J., 1983, Am. Rev. Respir. Dis., 127, 725
  5. Mead J., 1980, Am. Rev. Respir. Dis., 121, 339

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Metadata

Authors
McClaran, S. R., Harms, C. A., Pegelow, D. F., & Dempsey, J. A.
Affiliations
University of Wisconsin–Madison (US)
ORCID
Dempsey, Jerome A.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1998-06-01
Volume
84
Issue
6
Pages
1872-1881
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1998.84.6.1872
OpenAlex
W2156961077
Cited by
238
References
36
Citations by year
2026: 4 · 2025: 10 · 2024: 12 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 9 · 2016: 5 · 2015: 10 · 2014: 12 · 2013: 15 · 2012: 11
FWCI
9.89
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL 15469)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
sex differences in lung function, women, exercise hyperpnea, expiratory flow limitation, maximal expiratory flow, lung volume, ventilatory reserve, VO2max, treadmill running, helium-oxygen breathing, tidal volume, respiratory rate, respiratory mechanics
MeSH terms
Adolescent, Adult, Aerobiosis, Blood Gas Analysis, Blood Volume, Body Height, Female, Humans, Hydrogen-Ion Concentration, Lung, Lung Volume Measurements, Peak Expiratory Flow Rate, Potassium, Respiratory Function Tests, Vital Capacity, Exercise, Lactic Acid

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