CoChat
Sign Up
Cited by 247Cardiovascular and exercise physiologyRespiratory Support and MechanismsSports Performance and Training

Respiratory mechanics during exercise in endurance‐trained men and women

Open access
Guenette, Jordan A., Witt, Jonathan D., McKenzie, Donald C., Road, Jeremy D., Sheel, A. William·2007·The Journal of Physiology
DOI 10.1113/jphysiol.2006.126466PMC PMC2170830
Open this paper in CoChat — free account

Abstract

The purpose of this study was to compare the mechanics of breathing including the measurement of expiratory flow limitation, end‐expiratory lung volume, end‐inspiratory lung volume, and the work of breathing in endurance‐trained men (n= 8) and women (n= 10) during cycle exercise. Expiratory flow limitation was assessed by applying a negative expiratory pressure at the mouth. End‐expiratory lung volume and end‐inspiratory lung volume were determined by having subjects perform inspiratory capacity manoeuvres. Transpulmonary pressure, taken as the difference between oesophageal and airway opening pressure, was plotted against volume and integrated to determine the work of breathing. Expiratory flow limitation occurred in nine females (90%) and three males (43%) during the final stage of exercise. Females had a higher relative end‐expiratory lung volume (42 ± 8 versus 35 ± 5% forced vital capacity (FVC)) and end‐inspiratory lung volume (88 ± 5 versus 82 ± 7% FVC) compared to males at maximal exercise (P < 0.05). Women also had a higher work of breathing compared to men across a range of ventilations. On average, women had a work of breathing that was twice that of men at ventilations above 90 l min−1. These data suggest that expiratory flow limitation may be more common in females and that they experience greater relative increases in end‐expiratory lung volume and end‐inspiratory lung volume at maximal exercise compared to males. The higher work of breathing in women is probably attributed to their smaller lung volumes and smaller diameter airways. Collectively, these findings suggest that women utilize a greater majority of their ventilatory reserve compared to men and this is associated with a higher cost of breathing.

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2006.126466

Cites

121 of 121 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • These sex differences (mainly smaller lungs and maximal flow rates in women) may affect dynamic volumes because fit women may suffer from expiratory flow limitation that induces an increase in EELV.

    “These differences (mainly smaller lungs and maximal flow rates in women) may also affect dynamic volumes because fit women may suffer from expiratory flow limitation that induces an increase in EELV.132–134”

    From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [133]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Guenette, J. A., Witt, J. D., McKenzie, D. C., Road, J. D., & Sheel, A. W.
Affiliations
University of British Columbia (CA)
Corresponding author
Sheel, A. William
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2007-06-06
Volume
581
Issue
3
Pages
1309-1322
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2006.126466
PMC
PMC2170830
OpenAlex
W2122546182
Cited by
247
References
121
Citations by year
2026: 7 · 2025: 16 · 2024: 14 · 2023: 18 · 2022: 16 · 2021: 21 · 2020: 19 · 2019: 17 · 2018: 15 · 2017: 14 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 8 · 2012: 9
FWCI
20.44
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • cIRcle (University of British Columbia) (submittedVersion)
Funders
  • British Columbia Lung Association
  • Michael Smith Health Research BC
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
respiratory mechanics, physical activity, endurance training, sex differences, expiratory flow limitation, end-expiratory lung volume, end-inspiratory lung volume, work of breathing, transpulmonary pressure, ventilatory reserve, cycling exercise, women
MeSH terms
Adult, Bicycling, Expiratory Reserve Volume, Female, Forced Expiratory Flow Rates, Forced Expiratory Volume, Humans, Lung, Lung Volume Measurements, Male, Physical Endurance, Sex Factors, Vital Capacity, Work of Breathing, Exercise, Respiratory Mechanics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review