Cited by 98Exercise and Physiological ResponsesAntioxidant Activity and Oxidative StressBiochemical Acid Research Studies

α-lipoic acid supplementation: Tissue glutathione homeostasis at rest and after exercise

Khanna, Savita, Atalay, Mustafa, Laaksonen, David E., Gul, Mustafa, Roy, Sashwati, Sen, Chandan K.·1999·Journal of Applied Physiology

Abstract

Antioxidant nutrients have demonstrated potential in protecting against exercise-induced oxidative stress. alpha-Lipoic acid (LA) is a proglutathione dietary supplement that is known to strengthen the antioxidant network. We studied the effect of intragastric LA supplementation (150 mg/kg, 8 wk) on tissue LA levels, glutathione metabolism, and lipid peroxidation in rats at rest and after exhaustive treadmill exercise. LA supplementation increased the level of free LA in the red gastrocnemius muscle and increased total glutathione levels in the liver and blood. The exercise-induced decrease in heart glutathione S-transferase activity was prevented by LA supplementation. Exhaustive exercise significantly increased thiobarbituric acid-reactive substance levels in the liver and red gastrocnemius muscle. LA supplementation protected against oxidative lipid damage in the heart, liver, and red gastrocnemius muscle. This study reports that orally supplemented LA is able to favorably influence tissue antioxidant defenses and counteract lipid peroxidation at rest and in response to exercise.

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Crossref · 10.1152/jappl.1999.86.4.1191

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Authors
Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., & Sen, C. K.
Affiliations
  • University of Eastern Finland (FI)
  • Department of Physiology, Faculty of Medicine, University of Kuopio, 70211 Kuopio, Finland; and
  • Lawrence Berkeley National Laboratory (US)
Venue
Journal of Applied Physiology
Published
1999-04-01
Volume
86
Issue
4
Pages
1191-1196
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
OpenAlex
W2139641080
Cited by
98
References
38
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 2 · 2014: 6 · 2013: 6 · 2012: 5
FWCI
5.93
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Keywords
alpha-lipoic acid, glutathione homeostasis, exercise-induced oxidative stress, lipid peroxidation, glutathione S-transferase, antioxidant supplementation, gastrocnemius, heart, liver, TBARS
MeSH terms
Analysis of Variance, Animals, Physical Exertion, Glutathione, Glutathione Peroxidase, Glutathione Reductase, Glutathione Transferase, Heart, Homeostasis, Thioctic Acid, Liver, Male, Myocardium, Rats, Wistar, Thiobarbituric Acid Reactive Substances, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Dietary Supplements, Rats

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