α-lipoic acid supplementation: Tissue glutathione homeostasis at rest and after exercise
Abstract
Antioxidant nutrients have demonstrated potential in protecting against exercise-induced oxidative stress. alpha-Lipoic acid (LA) is a proglutathione dietary supplement that is known to strengthen the antioxidant network. We studied the effect of intragastric LA supplementation (150 mg/kg, 8 wk) on tissue LA levels, glutathione metabolism, and lipid peroxidation in rats at rest and after exhaustive treadmill exercise. LA supplementation increased the level of free LA in the red gastrocnemius muscle and increased total glutathione levels in the liver and blood. The exercise-induced decrease in heart glutathione S-transferase activity was prevented by LA supplementation. Exhaustive exercise significantly increased thiobarbituric acid-reactive substance levels in the liver and red gastrocnemius muscle. LA supplementation protected against oxidative lipid damage in the heart, liver, and red gastrocnemius muscle. This study reports that orally supplemented LA is able to favorably influence tissue antioxidant defenses and counteract lipid peroxidation at rest and in response to exercise.
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Alpha lipoic acid acts as a multi-functional antioxidant through rapid regeneration of glutathione.
“Specifically, alpha lipoic acid acts as a multi-functional antioxidant through rapid regeneration of glutathione [64,65].”
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works
Hayes, J. D., & Pulford, D. J. (1995) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239509083491 · Cited by 3,471 · see citing works
Antioxidant and redox regulation of gene transcription
Sen, C. K., & Packer, L. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635688 · Cited by 1,996 · see citing works
Self-citationAlpha-lipoic acid as a biological antioxidant
Packer, L., Witt, E. H., & Tritschler, H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00017-r · Cited by 1,995 · see citing works
Muscle fiber type composition of the rat hindlimb
Armstrong, R. B., & Phelps, R. O. (1984) · American Journal of Anatomy · doi:10.1002/aja.1001710303 · Cited by 1,004 · see citing works
The pharmacology of the antioxidant lipoic acid
Biewenga, G. P., Haenen, G. R. M. M., & Bast, A. (1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(96)00474-0 · Cited by 844 · see citing works
Regulation of cellular glutathione
Deneke, S. M., & Fanburg, B. L. (1989) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1989.257.4.l163 · Cited by 839 · see citing works
Oxidants and antioxidants in exercise
Sen, C. K. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.3.675 · Cited by 628 · see citing works
Self-citationExchange of cystine and glutamate across plasma membrane of human fibroblasts.
Bannai, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35926-4 · Cited by 543 · see citing works
Ziegler, D., Hanefeld, M., Ruhnau, K. J., Mei\ner, H. P., Lobisch, M., Sch�tte, K., Gries, F. A., & The ALADIN Study Group (1995) · Diabetologia · doi:10.1007/bf00400603 · Cited by 525 · see citing works
Role of membrane transport in metabolism and function of glutathione in mammals
Bannai, S., & Tateishi, N. (1986) · The Journal of Membrane Biology · doi:10.1007/bf01870891 · Cited by 386 · see citing works
Redox Signaling and the Emerging Therapeutic Potential of Thiol Antioxidants
Sen, C. K. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00672-2 · Cited by 358 · see citing works
Self-citationLipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
Han, D., Handelman, G. J., Marcocci, L., Sen, C. K., Roy, S., Kobuchi, H., Tritschler, H., Flohé, L., & Packer, L. (1997) · BioFactors · doi:10.1002/biof.5520060303 · Cited by 334 · see citing works
Self-citationOxidative stress during exercise: Implication of antioxidant nutrients
Ji, L. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00212-3 · Cited by 276 · see citing works
Jocelyn, P. C. (1967) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1967.tb00142.x · Cited by 271 · see citing works
Dröge, W., Eck, H., & Mihm, S. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90156-2 · Cited by 253 · see citing works
Sen, C. K., Marín, E., Kretzschmar, M., & Hänninen, O. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.4.1265 · Cited by 249 · see citing works
Self-citationα-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription
Packer, L., Roy, S., & Sen, C. K. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60980-1 · Cited by 240 · see citing works
Self-citationExercise-induced oxidative stress: glutathione supplementation and deficiency
Sen, C. K., Atalay, M., & Hänninen, O. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.5.2177 · Cited by 215 · see citing works
Self-citationNutritional biochemistry of cellular glutathione
Sen, C. K. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)00113-7 · Cited by 213 · see citing works
Self-citationInfluence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo.
Busse, E. F. G., Zimmer, G., Schopohl, B., & Kornhuber, B. (1992) · PubMed · Cited by 183 · see citing works
Sen, C. K., Packer, L., & Hänninen, O. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199512000-00023 · Cited by 135 · see citing works
Self-citationGmünder, H., Eck, H., & Dröge, W. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16263.x · Cited by 111 · see citing works
Regulation of Cellular Thiols in Human Lymphocytes by α-Lipoic Acid: A Flow Cytometric Analysis
Sen, C. K., Roy, S., Han, D., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00552-7 · Cited by 111 · see citing works
Self-citationα-Lipoic Acid Supplementation Prevents Symptoms of Vitamin E Deficiency
Podda, M., Tritschler, H., Ulrich, H., & Packer, L. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2431 · Cited by 107 · see citing works
α-Lipoic Acid Increases Intracellular Glutathione in a Human T-Lymphocyte Jurkat Cell Line
Han, D., Tritschler, H., & Packer, L. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1181 · Cited by 106 · see citing works
Modulation of cellular reducing equivalent homeostasis by α-lipoic acid
Roy, S., Sen, C. K., Tritschler, H., & Packer, L. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00764-2 · Cited by 85 · see citing works
Self-citationAntioxidant Activities of Dihydrolipoic Acid and its Structural Homologues
Suzuki, Y., Tsuchiya, M., & Packer, L. (1993) · Free Radical Research Communications · doi:10.3109/10715769309147348 · Cited by 72 · see citing works
Dikalov, S., Khramtsov, V. V., & Zimmer, G. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0067 · Cited by 63 · see citing works
Sen, C. K., Roy, S., Khanna, S., & Packer, L. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)99023-7 · Cited by 53 · see citing works
Self-citationGallagher, E. P., Buetler, T. M., Stapleton, P. L., WANG, C., Stahl, D., & Eaton, D. L. (1995) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1995.1171 · Cited by 48 · see citing works
Teichert, J., & Preiß, R. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00225-8 · Cited by 48 · see citing works
Han, D., Handelman, G. J., & Packer, L. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)51134-2 · Cited by 43 · see citing works
Biewenga, G. P., Dejong, J., & Bast, A. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1288 · Cited by 37 · see citing works
Metabolism of red cell glutathione
Srivastava, S. K. (1971) · Experimental Eye Research · doi:10.1016/s0014-4835(71)80041-6 · Cited by 31 · see citing works
Measurement of oxidative stress in vivo
Floyd, R. A. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90214-f · Cited by 20 · see citing works
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Finaud, J., Lac, G., & Filaire, E. (2006) · Sports Medicine · doi:10.2165/00007256-200636040-00004 · Cited by 771 · see citing works
Acute exercise and oxidative stress: a 30 year history
Fisher‐Wellman, K. H., & Bloomer, R. J. (2009) · Dynamic Medicine · doi:10.1186/1476-5918-8-1 · Cited by 684 · see citing works
Antioxidant and Prooxidant Activities of α-Lipoic Acid and Dihydrolipoic Acid
Moini, H., Packer, L., & Saris, N.-E. L. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9437 · Cited by 533 · see citing works
Thiol homeostasis and supplements in physical exercise
Sen, C. K., & Packer, L. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.653s · Cited by 475 · see citing works
Self-citationGlutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging
Lapenna, D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102066 · Cited by 239 · see citing works
Muscle-derived ROS and thiol regulation in muscle fatigue
Ferreira, L. F., & Reid, M. B. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00953.2007 · Cited by 230 · see citing works
Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
Mason, S. A., Trewin, A. J., Parker, L., & Wadley, G. D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101471 · Cited by 226 · see citing works
Patrick, L. (2002) · PubMed · Cited by 210 · see citing works
Diabetes, Oxidative Stress and Physical Exercise
Atalay, M., & Laaksonen, D. E. (2002) · Journal of Sports Science and Medicine · doi:10.52082/jssm.2002.1 · Cited by 203 · see citing works
Self-citationExercise training modulates heat shock protein response in diabetic rats
Atalay, M., Oksala, N., Laaksonen, D. E., Khanna, S., Nakao, C., Lappalainen, J., Roy, S., Hänninen, O., & Sen, C. K. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01183.2003 · Cited by 200 · see citing works
Self-citationAscensão, A. A. M. R., Ferreira, R. M., & Magalhães, J. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.04.076 · Cited by 160 · see citing works
Glutathione Participation in the Prevention of Cardiovascular Diseases
Matuz‐Mares, D., Riveros‐Rosas, H., Vilchis‐Landeros, M. M., & Vázquez‐Meza, H. (2021) · Antioxidants · doi:10.3390/antiox10081220 · Cited by 149 · see citing works
Response and adaptation of skeletal muscle to exercise - the role of reactive oxygen species
Niess, A. M. (2007) · Frontiers in bioscience · doi:10.2741/2431 · Cited by 146 · see citing works
Antioxidants in Exercise Nutrition
Sen, C. K. (2001) · Sports Medicine · doi:10.2165/00007256-200131130-00001 · Cited by 141 · see citing works
Self-citationGlutathione homeostasis in response to exercise training and nutritional supplements
Sen, C. K. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006910011048 · Cited by 137 · see citing works
Self-citationDietrich, M., Block, G., Hudes, M. L., Morrow, J. D., Norkus, E. P., Traber, M. G., Cross, C. E., & Packer, L. (2002) · PubMed · Cited by 132 · see citing works
Exercise-associated oxidative stress
Deaton, C. M., & Marlin, D. (2003) · Clinical techniques in equine practice · doi:10.1053/s1534-7516(03)00070-2 · Cited by 118 · see citing works
Endurance training attenuates exercise-induced oxidative stress in erythrocytes in rat
Öztaşan, N., Tayşi, S., Gümüştekin, K., Altınkaynak, K., Aktas, Ö., Timur, H., Şıktar, E., Keleş, M. S., Akar, S., Akçay, F., et al. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-1029-6 · Cited by 102 · see citing works
Roberts, J., Suckling, C., Peedle, G., Murphy, J., Dawkins, T., & Roberts, M. (2016) · Nutrients · doi:10.3390/nu8110733 · Cited by 99 · see citing works
“Specifically, alpha lipoic acid acts as a multi-functional antioxidant through rapid regeneration of glutathione [64,65].”
BackgroundPowers, S. K., Sollanek, K. J., Wiggs, M. P., Demirel, H. A., & Smuder, A. J. (2013) · Free Radical Research · doi:10.3109/10715762.2013.825371 · Cited by 97 · see citing works
Ai-jun, N., Wu, J.-M., Yu, D., & Wang, R. (2008) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2008.02.003 · Cited by 89 · see citing works
Gül, M., Demircan, B., Tayşi, S., Öztaşan, N., Gümüştekin, K., Şıktar, E., Polat, M., Akar, S., Akçay, F., & Dane, Ş. (2006) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2005.12.001 · Cited by 81 · see citing works
Protein Disulfide Levels and Lens Elasticity Modulation: Applications for Presbyopia
Garner, W. H., & Garner, M. H. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18413 · Cited by 80 · see citing works
Clinical cardioprotection and the value of conditioning responses
Peart, J. N., & Headrick, J. P. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00162.2009 · Cited by 77 · see citing works
Gül, M., Laaksonen, D. E., Atalay, M., Vider, J., & Hänninen, O. (2002) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1034/j.1600-0838.2002.120307.x · Cited by 76 · see citing works
Self-citationDietrich, M., Block, G., Benowitz, N. L., Morrow, J. D., Hudes, M. L., Jacob, P., Norkus, E. P., & Packer, L. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4502_06 · Cited by 75 · see citing works
Liu, C.-C., Huang, C., Lin, W., Hsieh, C.-C., Huang, S., Lin, S.-J., & Yang, S. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051541 · Cited by 73 · see citing works
Huong, D. T. T., & Ide, T. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507876227 · Cited by 68 · see citing works
Ali, H., & Dixit, S. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/376216 · Cited by 68 · see citing works
Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits
Winiarska, K., Malińska, D., Szymanski, K., Dudziak, M., & Bryła, J. (2007) · Biochimie · doi:10.1016/j.biochi.2007.11.010 · Cited by 67 · see citing works
Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats
Kon, M., Kimura, F., Akimoto, T., Tanabe, K., Murase, Y., IKEMUNE, S., & Kono, I. (2026) · PubMed · doi:10.22029/eir.2007.1632 · Cited by 63 · see citing works
Güzel, N. A., Hazar, S., & Erbaş, D. (2007) · Europe PMC (PubMed Central) · Cited by 63 · see citing works
Zhang, W., Chen, Q., Mai, K., Xu, W., Wang, X., & Liufu, Z. (2010) · Aquaculture Research · doi:10.1111/j.1365-2109.2010.02592.x · Cited by 60 · see citing works
Stanković, M. N., Mladenović, D. R., Ninković, M., Djuricic, I. D., Sobajic, S. S., Jorgačević, B. Z., Luka, S. R. D., Ješić-Vukićević, R., & Radosavljević, T. S. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0111 · Cited by 54 · see citing works
Dietary Antioxidants for the Athlete
Atalay, M., Lappalainen, J., & Sen, C. K. (2006) · Current Sports Medicine Reports · doi:10.1097/01.csmr.0000306504.71105.6e · Cited by 52 · see citing works
Self-citationEffects of grape seed extract supplementation on exercise-induced oxidative stress in rats
Belviranlı, M., Gökbel, H., Okudan, N., & Başaralı, K. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005496 · Cited by 50 · see citing works
Physical Exercise and Antioxidant Defenses in the Hearta
Atalay, M., & Sen, C. K. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09234.x · Cited by 48 · see citing works
Self-citationHeat shock protein 60 response to exercise in diabetes
Oksala, N., Laaksonen, D. E., Lappalainen, J., Khanna, S., Nakao, C., Hänninen, O., Sen, C. K., & Atalay, M. (2006) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.07.008 · Cited by 46 · see citing works
Self-citationOksala, N., Lappalainen, J., Laaksonen, D. E., Khanna, S., Kaarniranta, K., Sen, C. K., & Atalay, M. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1450 · Cited by 37 · see citing works
Self-citationElshazly, S. M., El‐Moselhy, M. A., & Barakat, W. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.042 · Cited by 36 · see citing works
Zembroń-Łacny, A., Słowińska-Lisowska, M. R., Szyguła, Z., Witkowski, K., Stefaniak, T., & Dziubek, W. (2009) · PubMed · Cited by 32 · see citing works
Endurance training attenuates the oxidative stress due to acute exhaustive exercise in rat liver
Tayşi, S., Öztaşan, N., Efe, H., Polat, M., Gümüştekin, K., Şıktar, E., Canakci, E., Akçay, F., Dane, Ş., & Gül, M. (2008) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.95.2008.4.2 · Cited by 31 · see citing works
Yan, Z., Wan, J.-W., Liu, J., Yao, B., Lu, Y., Guo, Z., & Li, Y. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115533 · Cited by 28 · see citing works
Kinnunen, S., Oksala, N., Hyyppä, S., Sen, C. K., Radak, Z. O., Laaksonen, D. E., Szabó, B., Jakus, J., & Atalay, M. (2009) · Free Radical Research · doi:10.1080/10715760903037673 · Cited by 27 · see citing works
Self-citationGül, M., Atalay, M., & Hänninen, O. (2003) · Europe PMC (PubMed Central) · Cited by 25 · see citing works
Self-citationZembron-Lacny, A., Szyszka, K., & Szygula, Z. (2007) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.rp009307 · Cited by 23 · see citing works
Elmas, M. A., Özakpınar, Ö. B., Kolgazi, M., Şener, G., Arbak, S., & Ercan, F. (2022) · Andrologia · doi:10.1111/and.14600 · Cited by 23 · see citing works
Antioxidant regulation of cell adhesion
Sen, C. K., & Roy, S. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200103000-00007 · Cited by 23 · see citing works
Self-citationGlutathione homeostasis in response to exercise training and nutritional supplements
Sen, C. K. (1999) · Springer eBooks · doi:10.1007/978-1-4615-5097-6_4 · Cited by 23 · see citing works
Self-citationLipoic Acid as an Antioxidant in Mature Thoroughbred Geldings: A Preliminary Study
Williams, C. A., Hoffman, R. M., Kronfeld, D. S., Hess, T. M., Saker, K. E., & Harris, P. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1628s · Cited by 22 · see citing works
Fu, Y., Nath, R. G., Dyba, M. D., Cruz, I. M., Pondicherry, S. R., Fernandez, A. I., Schultz, C. L., Yang, P., Pan, J., Desai, D. H., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.032 · Cited by 19 · see citing works
Chae, C., Shin, C., & Kim, H.-T. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.02.010 · Cited by 19 · see citing works
Effects of dietary α-lipoic acid enantiomers on hepatic fatty acid metabolism in rats
Ide, T., Azechi, A., Suzuki, N., Kunimatsu, Y., Nakajima, C., & Kitade, S. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.08.005 · Cited by 15 · see citing works
Unt, E., Kairane, Č., Vaher, I., & Zilmer, M. (2008) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
Ki, S. H., & Kim, S. G. (2008) · Xenobiotica · doi:10.1080/00498250802126920 · Cited by 14 · see citing works
Protective Effect of Lipoic Acid against Methylglyoxal-Induced Oxidative Stress in LLC-PK1 Cells
Kim, H. Y., Oi, Y., Kim, M., & Yokozawa, T. (2008) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.54.99 · Cited by 14 · see citing works
Lipoic acid and moderate swimming improves the estrous cycle and oxidative stress in Wistar rats
Martins, R. R., Macedo, U. B. D. O., Leite, L. D., de Rezende, A. A., Brandão‐Neto, J., & Almeida, M. D. G. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-074 · Cited by 14 · see citing works
Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
Anthony, R. M., MacLeay, J. M., Jewell, D. E., Brejda, J. J., & Gross, K. L. (2021) · Animals · doi:10.3390/ani11020274 · Cited by 13 · see citing works
Lappalainen, Z., Lappalainen, J., Laaksonen, D. E., Oksala, N., Khanna, S., Sen, C. K., & Atalay, M. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.3.206 · Cited by 12 · see citing works
Self-citationKumar, S., Budhwar, R., Nigam, A., & Priya, S. (2009) · Mutagenesis · doi:10.1093/mutage/gep033 · Cited by 11 · see citing works
Chelation therapy and vanadium: effect on reproductive organs in rats.
Shrivastava, S., Jadon, A., Shukla, S., & Mathur, R. (2007) · PubMed · Cited by 11 · see citing works
Influence of acute exercise on oxidative stress in chronic smokers.
Sürmen-Gür, E., Erdinc, A., Serdar, Z., & Gür, H. (2003) · Europe PMC (PubMed Central) · Cited by 10 · see citing works
Specialized dietary supplements
Williams, C. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-7020-3422-0.00019-5 · Cited by 10 · see citing works
The mechanism and prevention of mitochondrial injury after exercise
Li, M., Ning, B., & Wang, T. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00802-3 · Cited by 9 · see citing works
Hemolysis and Rhabdomyolysis after Marathon and Long Distance Running
Aaseth, J., & Birketvedt, G. S. (2012) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152212799857655 · Cited by 9 · see citing works
Prevention of chromate induced oxidative stress by alpha-lipoic acid.
Budhwar, R., & Kumar, S. (2005) · PubMed · Cited by 9 · see citing works
Jiang, S., Zhu, W., Wu, J., Li, C., Zhang, X., Li, Y., Cao, K., & Liu, L. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.08.006 · Cited by 8 · see citing works
Coleman, M. D., & Baker, C. D. (2001) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(01)00061-8 · Cited by 8 · see citing works
Lipid Lowering Effect of Ginseng and Alpha-Lipoicacid in Hypercholesterolemic Patients
Hamdan, D., Elfarok, M. O., EL-Denshry, E. S., Mahmoud, M. G., Asaaf, N., & Emam, M. (2013) · Cited by 7 · see citing works
Yang, Z., Tian, Y., Berr, S. S., & French, B. A. (2020) · Cardiology Research and Practice · doi:10.1155/2020/6759808 · Cited by 7 · see citing works
JiPing, S. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000468 · Cited by 7 · see citing works
Sen, C. K., & Roy, S. (2001) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(01)00085-0 · Cited by 7 · see citing works
Self-citationAntioxidants and physical exercise
Sen, C. K., & Goldfarb, A. H. (2000) · Elsevier eBooks · doi:10.1016/b978-044482650-3/50012-2 · Cited by 7 · see citing works
Self-citationEffect of jujube extract on oxidative injury in heart muscles of exhausted training rats
Liang, S. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr11.447 · Cited by 5 · see citing works
Oosthuyse, T., Bosch, A. N., & Millen, A. M. E. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-018-04060-y · Cited by 4 · see citing works
Sepehri, M. H. (2014) · American Journal of Sports Science · doi:10.11648/j.ajss.20140204.13 · Cited by 4 · see citing works
Almeida, C. I. M. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr12.301 · Cited by 4 · see citing works
Fernyhough, M. E., Helterline, D., VIERCK, J. L., Dodson, M. V., Bucci, L. R., & Feliciano, J. (2004) · Research in Sports Medicine · doi:10.1080/15438620490497323 · Cited by 3 · see citing works
Kim, W.-J., Kang, J.-Y., Kwon, D., Song, Y., & Lee, K. (2011) · Food Science and Biotechnology · doi:10.1007/s10068-011-0154-y · Cited by 3 · see citing works
Reactive Oxygen and Nitrogen Species and Liver Ischemia-Reperfusion Injury: Role of Lipoic Acid
Alban, F. T. E., Gyamfi, D., van Golen, R. F., & Heger, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-803951-9.00010-0 · Cited by 3 · see citing works
Effects of supplementation with α-lipoic acid on exercise-induced activation of coagulation
Weiss, C., Bierhaus, A., Nawroth, P. P., & Bärtsch, P. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.027 · Cited by 2 · see citing works
Alpha‐lipoic acid does not alter stress protein response to acute exercise in diabetic brain
Lappalainen, J., Lappalainen, Z., Oksala, N., Laaksonen, D. E., Khanna, S., Sen, C. K., & Atalay, M. (2010) · Cell Biochemistry and Function · doi:10.1002/cbf.1702 · Cited by 2 · see citing works
Self-citationPHYSICAL EXERCISE AND FREE RADICALS
Ohno, H., Suzuki, K., Hitomi, Y., Kimoto, K., Itoh, C., Miyazawa, N., & Kizaki, T. (2001) · 体力科學 · doi:10.7600/jspfsm1949.50.389 · Cited by 2 · see citing works
El-Karn, M. (2010) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2010.36294 · Cited by 1 · see citing works
The Uses and Benefits of Alpha Lipoic Acid
Mauldin, B. (2014) · Cited by 1 · see citing works
BİRİNCİ, M. C., & Karadeniz, A. (2023) · Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi · doi:10.17517/ksutfd.1080134 · Cited by 1 · see citing works
Wolne rodniki i antyoksydanty w wysiłku fizycznym i treningu
Lutosławska, G., & Hübner-Woźniak, E. (1999) · Żywienie Człowieka i Metabolizm · Cited by 1 · see citing works
Oral epithelium in the pathogenesis of periodontitis
Milward, M. R. (2010) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1 · see citing works
Błońska-Sikora, E. M., Orlewska, E., & Klusek, J. (2018) · Preprints.org · doi:10.20944/preprints201811.0356.v1 · Cited by 1 · see citing works
Modulation of Cigarette Smoke Effects by Diet and Antioxidants
Dietrich, M., & Block, G. (2007) · Springer eBooks · doi:10.1007/3-540-32232-9_7
Delport, C. J. (2013) · SUNScholar (Stellenbosch University)
Sepehri, M. H., Nikbakht, M., Habibi, A., & Moradi, M. (2014)
Exactas, F. D. C., & Exactas, C. (2012)
The Application of Lipoic Acid in Experimentally Induced Tympanosclerosis in Rats
Turan, F., Sayar, İ., & Salcan, İ. (2020) · Journal of Contemporary Medicine · doi:10.16899/jcm.634978
Effect of Creatine Monohydrate Support on Spermatogenesis in a Rat Exercise Model
Helvacıoğlu, F., Göktaş, T., Göktaş, G., Aykol, Z. C., Bozkurt, Z. Y., Akdeniz, G., Belet, Z., Dinç, E. J., Özkoç, İ., Tekindal, M. A., et al. (2025) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-025-00388-y
- Authors
- Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., & Sen, C. K.
- Affiliations
- University of Eastern Finland (FI)
- Department of Physiology, Faculty of Medicine, University of Kuopio, 70211 Kuopio, Finland; and
- Lawrence Berkeley National Laboratory (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1999-04-01
- Volume
- 86
- Issue
- 4
- Pages
- 1191-1196
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2139641080
- Cited by
- 98
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 2 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Keywords
- alpha-lipoic acid, glutathione homeostasis, exercise-induced oxidative stress, lipid peroxidation, glutathione S-transferase, antioxidant supplementation, gastrocnemius, heart, liver, TBARS
- MeSH terms
- Analysis of Variance, Animals, Physical Exertion, Glutathione, Glutathione Peroxidase, Glutathione Reductase, Glutathione Transferase, Heart, Homeostasis, Thioctic Acid, Liver, Male, Myocardium, Rats, Wistar, Thiobarbituric Acid Reactive Substances, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Dietary Supplements, Rats
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