Effect of Cysteine Derivatives Administration in Healthy Men Exposed to Intense Resistance Exercise by Evaluation of Pro-Antioxidant Ratio
Open accessAbstract
The aim of this study was to ascertain the influence of cysteine derivatives on pro-antioxidant equilibrium and to compare the antioxidant effectiveness of N-acetylcysteine, alpha-lipoic acid, and taurine by using Loverro's coefficient (pro-antioxidant ratio) in healthy men exposed to intensity-resistance exercise. Fifty-five men were randomly assigned to one of four groups: control (CON, placebo), N-acetylcysteine (NAC 1.8 g.day(-1), 3 days), alpha-lipoic acid (LIP 1.2 g.day(-1), 3 days), or taurine (TAU 3 g.day(-1), 3 days). The erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, lipid peroxidation products (TBARS), and plasma protein thiol concentrations were evaluated. The P/A ratio was determined from the mean values of TBARS, SOD, GPx, and CAT. The applied exercise at maximal intensity induced the significant changes in pro-antioxidant equilibrium toward peroxidation, which was proved by a 25% increase in TBARS concentration in the CON group. The peroxidation was significantly diminished by NAC (-14%) and LIP (-16%), whereas TAU had no effect on the TBARS concentration. Cysteine derivatives administration prevented exercise-induced decline in SOD activity and increased in GPx activity during exercise. CAT activity changed only in the LIP group. The estimation of P/A ratio showed the lowest level of pro-antioxidant equilibrium after LIP administration. In the CON group, P/A ratio was directly correlated with the protein thiols level (r = 0.495, p < 0.001). These data confirm the antioxidant action of tested cysteine derivatives, particularly lipoic acid, and demonstrate the practical application of P/A ratio to evaluate the effectiveness of antioxidants in athletes.
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Studies have supported the ability of taurine to function in an anti-oxidative role, which may promote an improved cellular environment to tolerate exercise stress.
“Finally, studies have also supported the ability of taurine to function in an anti-oxidative role, which may promote an improved cellular environment to tolerate exercise stress [634, 635].”
From ISSN exercise & sports nutrition review update: research & recommendations (2018) · cites this paper as [635]
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Cites
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.
Paglia, D. E., & Valentine, W. N. (1967) · PubMed · Cited by 10,776 · see citing works
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Alpha-lipoic acid as a biological antioxidant
Packer, L., Witt, E. H., & Tritschler, H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00017-r · Cited by 1,995 · see citing works
Drabkin, D. L. (1946) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41272-5 · Cited by 923 · see citing works
[37] Reaction of protein sulfhydryl groups with Ellman's reagent
Habeeb, A. F. S. A. (1972) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(72)25041-8 · Cited by 905 · see citing works
Hodgson, E. K., & Fridovich, I. (1975) · Biochemistry · doi:10.1021/bi00695a010 · Cited by 785 · see citing works
Thiol homeostasis and supplements in physical exercise
Sen, C. K., & Packer, L. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.653s · Cited by 475 · see citing works
Techniques in Free Radical Research
(1991) · Laboratory techniques in biochemistry and molecular biology · doi:10.1016/s0075-7535(08)x7003-2 · Cited by 441 · see citing works
Marzatico, F., Pansarasa, O., Bertorelli, L., Somenzini, L., & Valle, G. D. (1997) · PubMed · Cited by 252 · see citing works
Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men
Liu, Z., Qi, B., Zhang, M., Izumi, I., Kagamimori, S., Sokejima, S., & Yamagami, T. (2004) · Amino Acids · doi:10.1007/s00726-003-0002-3 · Cited by 200 · see citing works
Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo.
Busse, E. F. G., Zimmer, G., Schopohl, B., & Kornhuber, B. (1992) · PubMed · Cited by 183 · see citing works
Beuge, J. A., & Aust, S. D. (1978) · Cited by 172 · see citing works
Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress
Peake, J. M., & Suzuki, K. (2026) · PubMed · doi:10.22029/eir.2004.1610 · Cited by 165 · see citing works
The cytoprotective role of taurine in exercise-induced muscle injury
Dawson, R., Biasetti, M., Messina, S. M., & Dominy, J. E. (2002) · Amino Acids · doi:10.1007/s007260200017 · Cited by 136 · see citing works
Erythrocytic System under the Influence of Physical Exercise and Training
Szyguła, Z. (1990) · Sports Medicine · doi:10.2165/00007256-199010030-00004 · Cited by 130 · see citing works
Medved, I., Brown, M. J., Bjorksten, A. R., Leppik, J. A., Sostaric, S. M., & McKenna, M. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00884.2002 · Cited by 114 · see citing works
α-lipoic acid supplementation: Tissue glutathione homeostasis at rest and after exercise
Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., & Sen, C. K. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.4.1191 · Cited by 98 · see citing works
Tauler, P., Gimeno, I., Aguiló, A., Guix, P., & Pons, A. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004249900125 · Cited by 76 · see citing works
Mao, G. D., & Poznansky, M. J. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80675-7 · Cited by 70 · see citing works
Lipoperoxidation and antioxidant enzymes activity in pregnancy complicated with hypertension
Loverro, G., Greco, P., Capuano, F., Carone, D., Cormio, G., & Selvaggi, L. E. (1996) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(95)02561-8 · Cited by 68 · see citing works
Optimal and effective oral dose of taurine to prolong exercise performance in rat
Miyazaki, T., Matsuzaki, Y., Ikegami, T., Miyakawa, S., Doy, M., Tanaka, N., & Bouscarel, B. E. (2004) · Amino Acids · doi:10.1007/s00726-004-0133-1 · Cited by 67 · see citing works
Role of taurine in osmoregulation during endurance exercise
Cuisinier, C., de Welle, J. M., Verbeeck, R. K., POORTMANS, J. R., Ward, R. J., Sturbois, X., & Francaux, M. (2002) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0679-0 · Cited by 59 · see citing works
Effect of altitude training on the peroxidation and antioxidant enzymes in sportsmen
Woźniak, A., Drewa, G., Chęsy, G., Rakowski, A. Z., Rozwodowska, M., & Olszewska-Słonina, D. M. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200107000-00007 · Cited by 56 · see citing works
Mitochondrial Ageing and the Beneficial Role of α-Lipoic Acid
Palaniappan, A. R., & Dai, A. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9355-4 · Cited by 54 · see citing works
Effects of Antioxidant Supplementation and Exercise Training on Erythrocyte Antioxidant Enzymes
Marsh, S. A., Laursen, & Coombes, J. S. (2006) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.76.5.324 · Cited by 29 · see citing works
Nielsen, H. B., Kharazmi, A., Bolbjerg, M. L., et al. (2001) · International Journal of Sports Medicine · doi:10.1055/s-2001-13817 · Cited by 20 · see citing works
Strenuous exercise and action of antioxidant enzymes.
Vešović, D., Borjanović, S., Markovic, S., et al. (2003) · PubMed · Cited by 15 · see citing works
Does underwater rugby stimulate the over‐production of reactive oxygen species?
Çavaş, L. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1153 · Cited by 10 · see citing works
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Research works printed but not linked: 3
- Peake J, Suzuki K. Neutrophils, antioxidant supplements and exercise-induced oxidative stress. Exerc Immunol Rev. 2004;10:129-41.
- Klapcinska B, Kempa K, Mossakowska M, Derejczyk J. Blood antioxidant potential as a predictor of "successful aging"? Results of a study on polish centenarians. International Congress Medicina Sportiva Krakow 2006, Med Sport. 2006;10:47 (abstract).
- Zembron-Lacny A, Szyszka K, Sobanska B. Effect of strength exercise and N- acetylcysteine on metabolism of glutathione, oxidative damage and erythropoietin production. Med Sport. 2005;9:33-9.
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ISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945 · see citing works
Rutherford, J. A., Spriet, L. L., & Stellingwerff, T. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.4.322 · Cited by 101 · see citing works
- Authors
- Zembron-Lacny, A., Szyszka, K., & Szygula, Z.
- Venue
- The Journal of Physiological Sciences
- Publisher
- Physiological Society of Japan
- Published
- 2007
- Volume
- 57
- Issue
- 6
- Pages
- 343-348
- ISSN
- 1880-6546 (ISSN-L)
- 1880-6562
- OpenAlex
- W2020998335
- Cited by
- 23
- References
- 28
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2018: 1 · 2016: 2 · 2014: 2 · 2013: 2
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- cysteine derivatives, N-acetylcysteine, alpha-lipoic acid, taurine, exercise-induced oxidative stress, lipid peroxidation, superoxide dismutase, glutathione peroxidase, catalase, protein thiols, antioxidant supplementation, athletes
- MeSH terms
- Acetylcysteine, Administration, Oral, Adult, Antioxidants, Catalase, Glutathione Peroxidase, Health, Humans, Thioctic Acid, Male, Superoxide Dismutase, Taurine, Time Factors, Exercise, Thiobarbituric Acid Reactive Substances, Oxidative Stress
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