The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Active muscle and whole body lactate kinetics after endurance training in men
Abstract
We evaluated the hypotheses that endurance training decreases arterial lactate concentration ([lactate]a) during continuous exercise by decreasing net lactate release (L˙) and appearance rates (R a) and increasing metabolic clearance rate (MCR). Measurements were made at two intensities before [45 and 65% peak O 2 consumption (V˙o 2 peak)] and after training [65% pretrainingV˙o 2 peak, same absolute workload (ABT), and 65% posttrainingV˙o 2 peak, same relative intensity (RLT)]. Nine men (27.4 ± 2.0 yr) trained for 9 wk on a cycle ergometer, 5 times/wk at 75%V˙o 2 peak. Compared with the 65%V˙o 2 peak pretraining condition (4.75 ± 0.4 mM), [lactate]a decreased at ABT (41%) and RLT (21%) ( P < 0.05). L˙ decreased at ABT but not at RLT. Leg lactate uptake and oxidation were unchanged at ABT but increased at RLT. MCR was unchanged at ABT but increased at RLT. We conclude that 1) active skeletal muscle is not solely responsible for elevated [lactate]a; and 2) training increases leg lactate clearance, decreases whole body and leg lactate production at a given moderate-intensity power output, and increases both whole body and leg lactate clearance at a high relative power output.
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Cites
Glucose metabolism during leg exercise in man
Wahren, J., Felig, P., Ahlborg, G., & Jorfeldt, L. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106772 · Cited by 598
Increased plasma FFA uptake and oxidation during prolonged exercise in trained vs. untrained humans
Turcotte, L. P., Richter, E. A., & Kiens, B. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.6.e791 · Cited by 258
Disposal of blood [1-13c] lactate in humans during rest and exercise
Mazzeo, R. S., Brooks, G. A., Schoeller, D. A., & Budinger, T. F. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.1.232 · Cited by 189 · cited 2×
“(31) reported 82% oxidation of lactate Rd at 50% maximal O2 consumption and 78% oxidation at 75% maximal O2 consumption.”
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Cited by
The Science and Translation of Lactate Shuttle Theory
Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486
Self-citationLactate as a fulcrum of metabolism
Brooks, G. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101454 · Cited by 724
Self-citationThe anaerobic threshold: 50+ years of controversy
Poole, D. C., Rossiter, H. B., Brooks, G. A., & Gladden, L. B. (2021) · The Journal of Physiology · doi:10.1113/jp279963 · Cited by 312
Self-citationLactate in contemporary biology: a phoenix risen
Brooks, G. A., Arevalo, J. A., Osmond, A. D., Leija, R. G., Curl, C. C., & Tovar, A. P. (2022) · The Journal of Physiology · doi:10.1113/jp280955 · Cited by 269
Self-citationSan-Millán, I., & Brooks, G. A. (2018) · Sports Medicine · doi:10.1007/s40279-017-0751-x · Cited by 264
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Metadata
- Authors
- Bergman, B. C., Wolfel, E. E., Butterfield, G. E., Lopaschuk, G. D., Casazza, G. A., Horning, M. A., & Brooks, G. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1999-11-01
- Volume
- 87
- Issue
- 5
- Pages
- 1684-1696
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2199833104
- Cited by
- 279
- References
- 3
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bergman, B. C., Wolfel, E. E., Butterfield, G. E., Lopaschuk, G. D., Casazza, G. A., Horning, M. A., & Brooks, G. A. (1999). Active muscle and whole body lactate kinetics after endurance training in men. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1999.87.5.1684
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