The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Aging of skeletal muscle: a 12-yr longitudinal study
Abstract
The present study examines age-related changes in skeletal muscle size and function after 12 yr. Twelve healthy sedentary men were studied in 1985–86 (T1) and nine (initial mean age 65.4 ± 4.2 yr) were reevaluated in 1997–98 (T2). Isokinetic muscle strength of the knee and elbow extensors and flexors showed losses ( P < 0.05) ranging from 20 to 30% at slow and fast angular velocities. Computerized tomography ( n = 7) showed reductions ( P < 0.05) in the cross-sectional area (CSA) of the thigh (12.5%), all thigh muscles (14.7%), quadriceps femoris muscle (16.1%), and flexor muscles (14.9%). Analysis of covariance showed that strength at T1 and changes in CSA were independent predictors of strength at T2. Muscle biopsies taken from vastus lateralis muscles ( n = 6) showed a reduction in percentage of type I fibers (T1 = 60% vs. T2 = 42%) with no change in mean area in either fiber type. The capillary-to-fiber ratio was significantly lower at T2 (1.39 vs. 1.08; P = 0.043). Our observations suggest that a quantitative loss in muscle CSA is a major contributor to the decrease in muscle strength seen with advancing age and, together with muscle strength at T1, accounts for 90% of the variability in strength at T2.
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“aging has been associated with alterations in myosin heavy chain (MHC) distribution [90].”
From Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis (2018) · cites this paper as [90]
Citations
Cites
What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,080
Muscle biopsy: A modern approach
(1975) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(75)90022-2 · Cited by 1,387
Strength conditioning in older men: skeletal muscle hypertrophy and improved function
Frontera, W. R., Meredith, C. N., O'Reilly, K. P., Knuttgen, H. G., & Evans, W. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.3.1038 · Cited by 1,386
Self-citationTHE SPECIFICITY OF THE HISTOCHEMICAL METHOD FOR ADENOSINE TRIPHOSPHATAS
Padykula, H. A., & Herman, E. (1955) · Journal of Histochemistry & Cytochemistry · doi:10.1177/3.3.170 · Cited by 1,201
A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women
Frontera, W. R., HUGHES, V. A., Lutz, K. J., & Evans, W. J. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.2.644 · Cited by 1,011
Self-citationPadykula, H. A., & Herman, E. (1955) · Journal of Histochemistry & Cytochemistry · doi:10.1177/3.3.161 · Cited by 654
Muscle quality. I. Age-associated differences between arm and leg muscle groups
Lynch, N. A., Metter, E. J., Lindle, R. S., Fozard, J. L., Tobin, J. D., Roy, T. A., Fleg, J. L., & Hurley, B. F. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.1.188 · Cited by 596
Age-Associated Loss of Power and Strength in the Upper Extremities in Women and Men
Metter, E. J., Conwit, R., Tobin, J., & Fozard, J. L. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.5.b267 · Cited by 592
Aging of human muscle: structure, function and adaptability
Porter, M. M., Vandervoort, A. A., & Lexell, J. E. (1995) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1995.tb00026.x · Cited by 565
Suction applied to a muscle biopsy maximizes sample size
Evans, W. J., Phinney, S. D., & Young, V. R. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198201000-00018 · Cited by 525
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Research works printed but not linked: 5
- Aniansson A., 1983, Scand. J. Rehabil. Med., 15, 92
- Era P., 1997, Scand. J. Soc. Med. Suppl., 53, 25
- Evans W. J., 1982, Med. Sci. Sports Exerc., 14, 101
- Lexell J., 1991, J. Anat., 174, 239
- Schroll M., 1997, Aging, 9, 143
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Items 101–105 of 105
Han, S. J., Kim, S.-K., Fujimoto, W. Y., Kahn, S. E., Leonetti, D. L., & Boyko, E. J. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.10.003 · Cited by 17
“8 cm2 decline in thigh muscle area over 12 years of follow-up [30].”
BackgroundOrganotypic cultures as aging associated disease models
Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12
Of sound mind and body: Exploring the diet-strength interaction in healthy aging
Askow, A. T., McKenna, C. F., Box, A. G., Khan, N. A., Petruzzello, S. J., De Lisio, M., Phillips, S. M., & Burd, N. A. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00145 · Cited by 10
Li, N., Chen, S., He, Y., Chen, Y., Duan, X., He, W., Wang, Q., Liu, S., Liu, T., & Fang, H. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1522287 · Cited by 8
Hwang, J. H., & Jung, H. W. (2018) · Medicine · doi:10.1097/md.0000000000011534 · Cited by 8
Metadata
- Authors
- Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R.
- Affiliations
- Tufts University (US)
- Boston University (US)
- University of Arkansas for Medical Sciences (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-04-01
- Volume
- 88
- Issue
- 4
- Pages
- 1321-1326
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2184656706
- Cited by
- 1,443
- References
- 36
- Citations by year
- 2026: 30 · 2025: 44 · 2024: 46 · 2023: 71 · 2022: 59 · 2021: 83 · 2020: 83 · 2019: 88 · 2018: 81 · 2017: 57 · 2016: 70 · 2015: 71 · 2014: 80 · 2013: 71 · 2012: 67
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, sarcopenia, muscle strength decline, cross-sectional area, thigh muscle, quadriceps, vastus lateralis, muscle fiber type, type I muscle fibers, capillary-to-fiber ratio, isokinetic strength
- MeSH terms
- Aged, Aging, Capillaries, Elbow Joint, Humans, Isometric Contraction, Knee Joint, Longitudinal Studies, Male, Middle Aged, Time Factors, Tomography, X-Ray Computed, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development
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