The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Aging of skeletal muscle: a 12-yr longitudinal study
Abstract
The present study examines age-related changes in skeletal muscle size and function after 12 yr. Twelve healthy sedentary men were studied in 1985–86 (T1) and nine (initial mean age 65.4 ± 4.2 yr) were reevaluated in 1997–98 (T2). Isokinetic muscle strength of the knee and elbow extensors and flexors showed losses ( P < 0.05) ranging from 20 to 30% at slow and fast angular velocities. Computerized tomography ( n = 7) showed reductions ( P < 0.05) in the cross-sectional area (CSA) of the thigh (12.5%), all thigh muscles (14.7%), quadriceps femoris muscle (16.1%), and flexor muscles (14.9%). Analysis of covariance showed that strength at T1 and changes in CSA were independent predictors of strength at T2. Muscle biopsies taken from vastus lateralis muscles ( n = 6) showed a reduction in percentage of type I fibers (T1 = 60% vs. T2 = 42%) with no change in mean area in either fiber type. The capillary-to-fiber ratio was significantly lower at T2 (1.39 vs. 1.08; P = 0.043). Our observations suggest that a quantitative loss in muscle CSA is a major contributor to the decrease in muscle strength seen with advancing age and, together with muscle strength at T1, accounts for 90% of the variability in strength at T2.
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“aging has been associated with alterations in myosin heavy chain (MHC) distribution [90].”
From Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis (2018) · cites this paper as [90]
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“Over the age span from 20 to 80 years of age, there is approximately a 30% reduction in muscle mass and a decline in cross-sectional area of about 20% (14).”
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function
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Self-citation
Metadata
- Authors
- Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R.
- Affiliations
- Tufts University (US)
- Boston University (US)
- University of Arkansas for Medical Sciences (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-04-01
- Volume
- 88
- Issue
- 4
- Pages
- 1321-1326
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2184656706
- Cited by
- 1,443
- References
- 36
- Citations by year
- 2026: 30 · 2025: 44 · 2024: 46 · 2023: 71 · 2022: 59 · 2021: 83 · 2020: 83 · 2019: 88 · 2018: 81 · 2017: 57 · 2016: 70 · 2015: 71 · 2014: 80 · 2013: 71 · 2012: 67
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, sarcopenia, muscle strength decline, cross-sectional area, thigh muscle, quadriceps, vastus lateralis, muscle fiber type, type I muscle fibers, capillary-to-fiber ratio, isokinetic strength
- MeSH terms
- Aged, Aging, Capillaries, Elbow Joint, Humans, Isometric Contraction, Knee Joint, Longitudinal Studies, Male, Middle Aged, Time Factors, Tomography, X-Ray Computed, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development
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