Organotypic cultures as aging associated disease models
Open accessAbstract
Aging remains a primary risk factor for a host of diseases, including leading causes of death. Aging and associated diseases are inherently multifactorial, with numerous contributing factors and phenotypes at the molecular, cellular, tissue, and organismal scales. Despite the complexity of aging phenomena, models currently used in aging research possess limitations. Frequently used in vivo models often have important physiological differences, age at different rates, or are genetically engineered to match late disease phenotypes rather than early causes. Conversely, routinely used in vitro models lack the complex tissue-scale and systemic cues that are disrupted in aging. To fill in gaps between in vivo and traditional in vitro models, researchers have increasingly been turning to organotypic models, which provide increased physiological relevance with the accessibility and control of in vitro context. While powerful tools, the development of these models is a field of its own, and many aging researchers may be unaware of recent progress in organotypic models, or hesitant to include these models in their own work. In this review, we describe recent progress in tissue engineering applied to organotypic models, highlighting examples explicitly linked to aging and associated disease, as well as examples of models that are relevant to aging. We specifically highlight progress made in skin, gut, and skeletal muscle, and describe how recently demonstrated models have been used for aging studies or similar phenotypes. Throughout, this review emphasizes the accessibility of these models and aims to provide a resource for researchers seeking to leverage these powerful tools.
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The expansion of aHSEs enhances the application of OTC models for investigating therapeutic techniques, particularly in mimicking inflammatory skin diseases like psoriasis and atopic dermatitis, and in studying skin-related bacterial adhesion and infection.
“This expansion enhances the application of OTC models for investigating potential therapeutic techniques [18,60], particularly in mimicking inflammatory skin diseases like psoriasis and atopic dermatitis [59], while also studying skin-related bacterial adhesion and infection [22,45].”
From Diversity of human skin three-dimensional organotypic cultures (2024) · cites this paper as [60]
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Lacrimal gland spheroids in tissue specific hydrogel for dry eye modelling
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Evaluation of the anti-ageing potential of manganese ion in human dermal fibroblasts
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- Authors
- Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T.
- Affiliations
- University of California, Riverside (US)
- Corresponding author
- Morgan, Joshua T.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2022-11-22
- Volume
- 14
- Issue
- 22
- Pages
- 9338-9383
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC9740367
- OpenAlex
- W4309685095
- Cited by
- 12
- References
- 462
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 2
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (CAREER, 2046093)
- American Heart Association (19IPLOI34760636)
- California Institute of Regenerative Medicine (EDUC4-12752)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- organotypic culture, age-related diseases, tissue engineering, skin, intestine, skeletal muscle, in vitro disease model
- MeSH terms
- Skin, Tissue Engineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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