The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia
Abstract
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to the lack of oxygen in mammalian cells. HIF-1 consists of two proteins, HIF-1α and HIF-1β. HIF-1α accumulates under hypoxic conditions, whereas HIF-1β is constitutively expressed. HIF-1α and HIF-1β expression were measured during adaptation to hypobaric hypoxia (0.5 atm) in rat cerebral cortex. Western blot analyses indicated that HIF-1α rapidly accumulated during the onset of hypoxia and did not fall for 14 days but fell to normal by 21 days despite the continuous low arterial oxygen tension. Immunostaining showed that neurons, astrocytes, ependymal cells, and possibly endothelial cells were the cell types expressing HIF-1α. Genes with hypoxia-responsive elements were activated under these conditions, as evidenced by elevated vascular endothelial growth factor and glucose transporter-1 mRNA levels. When 21-day-adapted rats were exposed to a more severe hypoxic challenge (8% oxygen), HIF-1α accumulated again. On the basis of these results, we speculate that the vascular remodeling and metabolic changes triggered during prolonged hypoxia are capable of restoring normal tissue oxygen levels.
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Cites
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Self-citation(1999) · PubMed · Cited by 2,204
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · cited 3×
“HIF-1b serves as heterodimerization partner for several other transcription factors and is constitutively expressed, whereas HIF-1a is unique to HIF-1 and its expression is tightly regulated by cellular oxygen concentration (22, 23).”
BackgroundSalceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674
Oxygen sensing and molecular adaptation to hypoxia
Bunn, H. F., & Poyton, R. O. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.3.839 · Cited by 1,172
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80571-7 · Cited by 862
Yu, A. Y., Shimoda, L. A., Iyer, N. V., Huso, D. L., Sun, X., McWilliams, R., Beaty, T., Sham, J. S. K., Wiener, C. M., Sylvester, J. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5912 · Cited by 656
Expression of hypoxia-inducible factor 1: mechanisms and consequences
Semenza, G. L. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00292-0 · Cited by 511
Bergeron, M., Yu, A. Y., Solway, K. E., Semenza, G. L., & Sharp, F. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00845.x · Cited by 412
Cited by
Aliev, G., Priyadarshini, M., Reddy, V., Grieg, N. H., Kaminsky, Y., Cacabelos, R., Ashraf, G., Jabir, N. R., Kamal, M. A., Nikolenko, V. N., et al. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227161303 · Cited by 138
Ward, N. L., & Lamanna, J. C. (2004) · Neurological Research · doi:10.1179/016164104x3798 · Cited by 122
Self-citationPetri, S., Calingasan, N. Y., Alsaied, O. A., Wille, E., Kiaei, M., Friedman, J. E., Baranova, O., Chavez, J. C., & Beal, M. F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04604.x · Cited by 55
Evaluation of BCAS1-positive immature oligodendrocytes after cerebral ischemic stroke and SVD
Jiang, G., Ayaki, T., Maki, T., Yasuda, K., Yoshii, D., Kaji, S., & Takahashi, R. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137405 · Cited by 11
Metadata
- Authors
- Chávez, J. C., Agani, F., Pichiule, P., & LaManna, J. C.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-11-01
- Volume
- 89
- Issue
- 5
- Pages
- 1937-1942
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2179556324
- Cited by
- 257
- References
- 26
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chávez, J. C., Agani, F., Pichiule, P., & LaManna, J. C. (2000). Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia. Journal of Applied Physiology. https://doi.org/10.1152/jappl.2000.89.5.1937
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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