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Cited by 11Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Evaluation of BCAS1-positive immature oligodendrocytes after cerebral ischemic stroke and SVD

Jiang, Guanhua, Ayaki, Takashi, Maki, Takakuni, Yasuda, Ken, Yoshii, Daisuke, Kaji, Seiji, Takahashi, Ryosuke·2023·Neuroscience Letters
DOI 10.1016/j.neulet.2023.137405
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Abstract

Ischemic cerebrovascular disease is an important cause of physical disability and dementia. Oligodendrocytes (OLGs), which differentiate from oligodendrocyte precursor cells (OPCs), are crucial for remyelination of the damaged brain and functional recovery. Breast carcinoma amplified sequence 1 (BCAS1) has recently been shown to be highly expressed in newly formed pre-myelinating oligodendrocytes (pre-mOLGs), while its expression level is reduced in mature OLGs. In this study, we analyzed BCAS1 expression by immunohistochemical analysis of human post-mortem brain tissue from six stroke patients (death within 2 months after stroke onset) and eight small vessel disease (SVD) patients. Control post-mortem brain tissue was from eight age-matched patients without any obvious central nervous system (CNS) pathology. The Olig2 expression in the area corresponding to the same section of the BCAS1-stained slice was analyzed to determine the total oligodendrocyte lineage. The percentage of differentiating OPCs in the oligodendrocyte lineage was calculated as the ratio of BCAS1+ to Olig2+ cells (BCAS1+/Olig2+). The stroke and SVD cases showed demyelination with decreased expression of myelin basic protein (MBP, a mature OLG marker). The stroke cases showed significantly increased numbers of early-stage BCAS1+ cells with an immature morphology and Olig2+ cells (pan-oligodendrocyte lineages) in the peri-infarct areas in both the cortex and white matter, but showed no increase in the number…

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  • BCAS1+ oligodendrocytes in the cortex appear in two main phenotypes: resting cells with few or no immunopositive processes, prevailing in the healthy adult brain, and activated cells with pre-myelinating/myelinating morphology characterized by internode formation.

    “BCAS1+ oligodendrocytes in the cortex appear in two main phenotypes: cells with few or no immunopositive processes, prevailing in the healthy adult brain (‘resting’ BCAS1+ oligodendrocytes; arrows in Fig. 1A) and cells with a pre-myelinating morphology with multiple branches and myelinating morphology, characterized by internode formation (‘activated’ BCAS1+ oligodendrocytes; arrowheads in Fig. 1A”

    From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [38]

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Authors
Jiang, G., Ayaki, T., Maki, T., Yasuda, K., Yoshii, D., Kaji, S., & Takahashi, R.
Affiliations
Kyoto University (JP)
Corresponding author
Ayaki, Takashi
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2023-08
Volume
812
Pages
137405
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/j.neulet.2023.137405
OpenAlex
W4384937289
Cited by
11
References
9
Citations by year
2026: 4 · 2025: 4 · 2024: 3
FWCI
1.28
Type
journal article
Language
en
Update notices
erratum (2024-03-28)
Open access
closed
Licence
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science (19\u202FK16277)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
BCAS1, oligodendrocyte precursor cells, ischemic stroke, cerebral small vessel disease, remyelination, demyelination, Olig2, myelin basic protein, oligodendrocyte maturation, postmortem brain
MeSH terms
Oligodendrocyte Precursor Cells, Ischemic Stroke, Cell Differentiation, Humans, Myelin Sheath, Neoplasm Proteins, Oligodendroglia, Stroke

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