The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Invited Review: Regulation of myosin phosphorylation in smooth muscle
Abstract
Phosphorylation of the regulatory light chains of myosin II (rMLC) by the Ca 2+/calmodulin-dependent myosin light-chain kinase (MLCK) and dephosphorylation by a type 1 phosphatase (MLCP), which is targeted to myosin by a regulatory subunit (MYPT1), are the predominant mechanisms of regulation of smooth muscle tone. The activities of both enzymes are modulated by several protein kinases. MLCK is inhibited by the Ca 2+/calmodulin-dependent protein kinase II, whereas the activity of MLCP is increased by cGMP and perhaps also cAMP-dependent protein kinases. In either case, this results in a decrease in the Ca 2+sensitivity of rMLC phosphorylation and force production. The activity of MLCP is inhibited by Rho-associated kinase, one of the effectors of the monomeric GTPase Rho, and protein kinase C, leading to an increase in Ca 2+sensitivity. Hence, smooth muscle tone appears to be regulated by a network of activating and inactivating intracellular signaling cascades.
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Cites
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
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Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
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Signal transduction and regulation in smooth muscle
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Emergent Properties of Networks of Biological Signaling Pathways
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The Function of Myosin and Myosin Light Chain Kinase Phosphorylation in Smooth Muscle
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Mechanisms of smooth muscle contraction
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Sauzeau, V., Le Jeune, H., Cario-Toumaniantz, C., Smolenski, A., Lohmann, S. M., Bertoglio, J., Chardin, P., Pacaud, P., & Loirand, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000753200 · Cited by 602
Cited by
Brozovich, F. V., Nicholson, C. J., Degen, C. V., Gao, Y. Z., Aggarwal, M., & Morgan, K. G. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.010652 · Cited by 542
Suh, B.-C., & Hille, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00790-0 · Cited by 476
Regulation of Blood Pressure and Salt Homeostasis by Endothelin
Kohan, D. E., Rossi, N. F., Inscho, E. W., & Pollock, D. M. (2011) · Physiological Reviews · doi:10.1152/physrev.00060.2009 · Cited by 433
Münzel, T., Feil, R., Mülsch, A., Lohmann, S. M., Hofmann, F., & Walter, U. (2003) · Circulation · doi:10.1161/01.cir.0000094403.78467.c3 · Cited by 316
Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus
Ratz, P. H., Berg, K. M., Urban, N. H., & Miner, A. S. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00529.2004 · Cited by 287
Metadata
- Authors
- Pfitzer, G.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2001-07-01
- Volume
- 91
- Issue
- 1
- Pages
- 497-503
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1831347542
- Cited by
- 315
- References
- 72
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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