The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Regulation of Blood Pressure and Salt Homeostasis by Endothelin
Open accessAbstract
Endothelin (ET) peptides and their receptors are intimately involved in the physiological control of systemic blood pressure and body Na homeostasis, exerting these effects through alterations in a host of circulating and local factors. Hormonal systems affected by ET include natriuretic peptides, aldosterone, catecholamines, and angiotensin. ET also directly regulates cardiac output, central and peripheral nervous system activity, renal Na and water excretion, systemic vascular resistance, and venous capacitance. ET regulation of these systems is often complex, sometimes involving opposing actions depending on which receptor isoform is activated, which cells are affected, and what other prevailing factors exist. A detailed understanding of this system is important; disordered regulation of the ET system is strongly associated with hypertension and dysregulated extracellular fluid volume homeostasis. In addition, ET receptor antagonists are being increasingly used for the treatment of a variety of diseases; while demonstrating benefit, these agents also have adverse effects on fluid retention that may substantially limit their clinical utility. This review provides a detailed analysis of how the ET system is involved in the control of blood pressure and Na homeostasis, focusing primarily on physiological regulation with some discussion of the role of the ET system in hypertension.
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Protective Role of Reactive Astrocytes in Brain Ischemia
Li, L., Lundkvist, A., Andersson, D., Wilhelmsson, U., Nagai, N., Pardo, A. C., Nodin, C., Ståhlberg, A., Aprico, K., Larsson, K., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600546 · Cited by 505
Amiri, F., Virdis, A., Neves, M. F., Iglarz, M., Seidah, N. G., Touyz, R. M., Reudelhuber, T. L., & Schiffrin, E. L. (2004) · Circulation · doi:10.1161/01.cir.0000144462.08345.b9 · Cited by 346
Molecular Regulation of the Endothelin-1 Gene by Hypoxia
Yamashita, K., Discher, D. J., Hu, J., Bishopric, N. H., & Webster, K. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011344200 · Cited by 340
Endothelial dysfunction in salt-sensitive essential hypertension
Bragulat, E., de la Sierra, A., Antonio, M. T., & Coca, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.444 · Cited by 172
Role of tyrosine kinase pathways in ETB receptor activation of NHE3
Chu, T. S., Tsuganezawa, H., Peng, Y., Cano, A., Yanagisawa, M., & Alpern, R. J. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.3.c763 · Cited by 99
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Davenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011833 · Cited by 772
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Metadata
- Authors
- Kohan, D. E., Rossi, N. F., Inscho, E. W., & Pollock, D. M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2011-01
- Volume
- 91
- Issue
- 1
- Pages
- 1-77
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2041376120
- Cited by
- 433
- References
- 6
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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