The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Human skeletal muscle responses vary with age and gender during fatigue due to incremental isometric exercise
Abstract
The purpose of this study was to compare the magnitude and mechanisms of ankle dorsiflexor muscle fatigue in 20 young (33 ± 6 yr, mean ± SD) and 21 older (75 ± 6 yr) healthy men and women of similar physical activity status. Noninvasive measures of central and peripheral (neuromuscular junction, sarcolemma) muscle activation, muscle contractile function, and intramuscular energy metabolism were made before, during, and after incremental isometric exercise. Older subjects fatigued less than young ( P < 0.01); there was no effect of gender on fatigue ( P = 0.24). For all subjects combined, fatigue was modestly related to preexercise strength ( r = 0.49, P < 0.01). Neither central (central activation ratio) nor peripheral (compound muscle action potential) activation played a significant role in fatigue in any group. During exercise, intracellular concentrations of P i and H 2 PO[Formula: see text] increased more and pH fell more in young compared with older subjects ( P < 0.01) and in men compared with women ( P < 0.01). These varied metabolic responses to exercise suggest a greater reliance on nonoxidative sources of ATP in young compared with older subjects and in men compared with women. These results suggest that the mechanisms of fatigue vary with age and gender, regardless of whether differences in the magnitude of fatigue are observed.
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Cites
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BackgroundMotor unit firing rates and contractile properties in tibialis anterior of young and old men
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Cited by
Sex differences in human fatigability: mechanisms and insight to physiological responses
Hunter, S. K. (2014) · Acta Physiologica · doi:10.1111/apha.12234 · Cited by 595
Effect of strength training on human patella tendon mechanical properties of older individuals
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Possible Stimuli for Strength and Power Adaptation: Acute Mechanical Responses
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Sex-Related Differences in Gene Expression in Human Skeletal Muscle
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“There is sexual dimorphism of skeletal muscle in overall mass, size of individual fibers, activities of several metabolic enzymes, lipid content and oxidation, relative expression of different myosin isoforms, fatigability, and expression of a number of genes [1–9].”
Muscle Fatigue in Males and Females during Multiple-Sprint Exercise
Billaut, F., & Bishop, D. (2009) · Sports Medicine · doi:10.2165/00007256-200939040-00001 · Cited by 169
Metadata
- Authors
- Kent-Braun, J. A., Ng, A. V., Doyle, J. W., & Towse, T. F.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2002-11-01
- Volume
- 93
- Issue
- 5
- Pages
- 1813-1823
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2134822922
- Cited by
- 351
- References
- 8
- FWCI
- 26.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kent-Braun, J. A., Ng, A. V., Doyle, J. W., & Towse, T. F. (2002). Human skeletal muscle responses vary with age and gender during fatigue due to incremental isometric exercise. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00091.2002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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