Myoglobin concentration in skeletal muscle fibers of chronic heart failure patients
Open accessAbstract
The purpose of this study was to determine the myoglobin concentration in skeletal muscle fibers of chronic heart failure (CHF) patients and to calculate the effect of myoglobin on oxygen buffering and facilitated diffusion. Myoglobin concentration, succinate dehydrogenase (SDH) activity, and cross-sectional area of individual muscle fibers from the vastus lateralis of five control and nine CHF patients were determined using calibrated histochemistry. CHF patients compared with control subjects were similar with respect to myoglobin concentration: type I fibers 0.69 +/- 0.11 mM (mean +/- SD), type II fibers 0.52 +/- 0.07 mM in CHF vs. type I fibers 0.70 +/- 0.09 mM, type II fibers 0.49 +/- 0.07 mM in control, whereas SDH activity was significantly lower in CHF in both fiber types (P < 0.01). The myoglobin concentration in type I fibers was higher than in type II fibers (P < 0.01). Consequently, the oxygen buffering capacity, calculated from myoglobin concentration/SDH activity was increased in CHF: type I fibers 11.4 +/- 2.1 s, type II fibers 13.6 +/- 3.9 s in CHF vs. type I fibers 7.8 +/- 0.9 s, type II fibers 7.5 +/- 1.0 s in control, all P < 0.01). The calculated extracellular oxygen tension required to prevent core anoxia (Po2(crit)) in muscle fibers was similar when controls were compared with patients in type I fibers 10.3 +/- 0.9 Torr in CHF and 11.5 +/- 3.3 Torr in control, but was lower in type II fibers of patients 6.1 +/- 2.8 Torr in CHF and 14.7 +/- 6.2 Torr in control, P < 0.01. The lower Po2(crit) of type II fibers may facilitate oxygen extraction from capillaries. Reduced exercise tolerance in CHF is not due to myoglobin deficiency.
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High concentrations of hemoglobin and myoglobin in red blood cells and cardiac/skeletal muscle determine that the reaction between their hemes and NO will be fast and might inhibit NO-signaling.
“the high concentrations of hemoglobin and myoglobin in red blood cells (20 mM) and cardiac/skeletal muscle (300-900 μM) [31, 32], determines that the reaction between their hemes and NO will be fast and might inhibit NO-signaling.”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [31]
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- Authors
- Bekedam, M. A., van Beek-Harmsen, B. J., van Mechelen, W., Boonstra, A., & van der Laarse, W. J.
- Affiliations
- Departments of Cardiology,
- Physiology, and
- Department of Public and Occupational Health and EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
- Amsterdam Cardiovascular Sciences (NL)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2009-10
- Volume
- 107
- Issue
- 4
- Pages
- 1138-1143
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC2763838
- OpenAlex
- W2083496094
- Cited by
- 37
- References
- 54
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myoglobin, chronic heart failure, skeletal muscle fibers, succinate dehydrogenase activity, muscle fiber type, type I muscle fibers, type II fibers, critical oxygen tension, muscle oxygen extraction, exercise tolerance, vastus lateralis
- MeSH terms
- Adult, Aged, Buffers, Chronic Disease, Female, Heart Failure, Humans, Male, Middle Aged, Myoglobin, Oxygen, Oxygen Consumption, Succinate Dehydrogenase, Case-Control Studies, Exercise Tolerance, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Quadriceps Muscle
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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