Carnosine, Oxidative and Carbonyl Stress, Antioxidants, and Muscle Fiber Characteristics of Quadriceps Muscle of Patients with COPD
Open accessAbstract
Carnosine, particularly present in fast-twitch fibers, was investigated in the quadriceps of patients with chronic obstructive pulmonary disease (COPD). Carnosine concentration was similar between patients with COPD and healthy controls but was 30% lower in patients with severe/very severe COPD, despite their high proportion of fast-twitch fibers, versus patients with mild/moderate COPD. As no oxidative/carbonyl stress markers or antioxidants were affected, the observed carnosine deficiency is thought to be a possible first sign of muscle redox balance abnormalities.
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Carnosine is unchanged in the muscle of COPD patients compared to healthy controls, but in COPD patients it is decreased in the quadriceps of GOLD III-IV patients compared to GOLD I-II, despite an increased proportion of type II myofibers.
“Finally, the antioxidant protein carnosine, mainly present in type II myofibers, has been reported to be unchanged in the muscle of COPD patients compared to healthy controls; however, in COPD patients, carnosine was decreased in the quadriceps of GOLD III–IV patients compared to GOLD I–II, despite their increased proportion of type II myofibers [125].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [125]
The absence of increased carbonylation in the quadriceps muscle of COPD patients compared to healthy controls has also been reported.
“However, the absence of increased carbonylation in the quadriceps muscle of COPD patients compared to healthy controls has also been reported [125].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [125]
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Cites
Everaert, I., Mooyaart, A., Baguet, A., Zutinic, A., Baelde, H., Achten, E., Taes, Y., De Heer, E., & Derave, W. (2011) · Amino Acids · doi:10.1007/s00726-010-0749-2 · Cited by 140 · see citing works
Self-citationCarnosine and taurine contents in individual fibres of human vastus lateralis muscle
C. Harris, R., Dunnett, M., & Greenhaff, P. L. (1998) · Journal of Sports Sciences · doi:10.1080/026404198366443 · Cited by 113 · see citing works
Wang, L., Tang, Y., Liu, S., Mao, S., Ling, Y., Liu, D., He, X., & Wang, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065675 · Cited by 97 · see citing works
Varanoske, A., Hoffman, J., Church, D., Wang, R., Baker, K., Dodd, S., Coker, N., Oliveira, L., Dawson, V., Fukuda, D., et al. (2017) · Nutrients · doi:10.3390/nu9090988 · Cited by 30 · see citing works
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Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
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- Authors
- De Brandt, J., Burtin, C., Pomiès, P., Vandenabeele, F., Verboven, K., Aumann, J., Blancquaert, L., Everaert, I., Van Ryckeghem, L., Cops, J., Hayot, M., Spruit, M. A., & Derave, W.
- Affiliations
- Hasselt University, Faculty of Rehabilitation Sciences, REVAL - Rehabilitation Research Center, Diepenbeek, Belgium
- Hasselt University (BE)
- Centre National de la Recherche Scientifique (FR)
- Jessa Hospital (BE)
- Ghent University (BE)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Burtin, C.
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2021-10-01
- Volume
- 131
- Issue
- 4
- Pages
- 1230-1240
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W3185816755
- Cited by
- 12
- References
- 4
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- HAL (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Document Server@UHasselt (UHasselt) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Limburgs Kankerfonds
- Fonds Wetenschappelijk Onderzoek (11B4718N)
- Topics
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- carnosine, chronic obstructive pulmonary disease, oxidative stress, carbonyl stress, antioxidants, muscle fiber composition, fast-twitch fibers, quadriceps
- MeSH terms
- Antioxidants, Carnosine, Humans, Oxidation-Reduction, Oxidative Stress, Muscle, Skeletal, Muscle Fibers, Skeletal, Pulmonary Disease, Chronic Obstructive, Quadriceps Muscle
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