Metabonomic Profiling of Serum and Urine by 1H NMR-Based Spectroscopy Discriminates Patients with Chronic Obstructive Pulmonary Disease and Healthy Individuals
Open accessAbstract
Chronic obstructive pulmonary disease (COPD) has seriously impacted the health of individuals and populations. In this study, proton nuclear magnetic resonance ((1)H NMR)-based metabonomics combined with multivariate pattern recognition analysis was applied to investigate the metabolic signatures of patients with COPD. Serum and urine samples were collected from COPD patients (n = 32) and healthy controls (n = 21), respectively. Samples were analyzed by high resolution (1)H NMR (600 MHz), and the obtained spectral profiles were then subjected to multivariate data analysis. Consistent metabolic differences have been found in serum as well as in urine samples from COPD patients and healthy controls. Compared to healthy controls, COPD patients displayed decreased lipoprotein and amino acids, including branched-chain amino acids (BCAAs), and increased glycerolphosphocholine in serum. Moreover, metabolic differences in urine were more significant than in serum. Decreased urinary 1-methylnicotinamide, creatinine and lactate have been discovered in COPD patients in comparison with healthy controls. Conversely, acetate, ketone bodies, carnosine, m-hydroxyphenylacetate, phenylacetyglycine, pyruvate and α-ketoglutarate exhibited enhanced expression levels in COPD patients relative to healthy subjects. Our results illustrate the potential application of NMR-based metabonomics in early diagnosis and understanding the mechanisms of COPD.
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PAA conjugation to glycine generating PAGly has been noted.
“In addition to PAGln, PAA conjugation to the amino acid glycine (Gly) generating PAGly has also been noted (Gonzalez-Guardia et al., 2015; Wang et al., 2013).”
From A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors (2020) · cites this paper as Wang et al., 2013
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- Authors
- Wang, L., Tang, Y., Liu, S., Mao, S., Ling, Y., Liu, D., He, X., & Wang, X.
- Affiliations
- Fourth Affiliated Hospital of China Medical University (CN)
- Corresponding author
- Wang, Xiaoge
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-06-06
- Volume
- 8
- Issue
- 6
- Pages
- e65675
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3675021
- OpenAlex
- W1972864198
- Cited by
- 97
- References
- 63
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 4 · 2019: 13 · 2018: 13 · 2017: 10 · 2016: 7 · 2015: 11 · 2014: 5
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chinese Medical Association
- China Medical University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Keywords
- chronic obstructive pulmonary disease, metabolomics, serum metabolites, urinary metabolites, 1H NMR, metabolic signatures, branched-chain amino acids, N1-methylnicotinamide, creatinine, lactate, ketone bodies, carnosine, early diagnosis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Amino Acids, Amino Acids, Branched-Chain, Female, Humans, Lipoproteins, Male, Middle Aged, Magnetic Resonance Spectroscopy, Phosphorylcholine, Pulmonary Disease, Chronic Obstructive, Metabolomics
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