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Cited by 61Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleepRespiratory and Cough-Related Research

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects

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Berry, Richard B., White, David P., Roper, John, Pillar, Giora, Fogel, Robert B., Stanchina, Michael, Malhotra, Atul·2003·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00324.2002
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Abstract

We hypothesized that the response of the genioglossus to negative pressure during wakefulness should be intact in obstructive sleep apnea (OSA) patients despite published evidence showing impairment of the response of palatal muscles (Mortimore IL and Douglas NJ. Am J Respir Crit Care Med156: 867–873, 1997). Thus the response of the genioglossus to brief nasal negative pressure applications (NPAs) in early inspiration was compared between OSA patients and an age-matched group of normal subjects at two study sites ( n = 11 per group in Long Beach, n = 14 per group in Boston). Subjects were studied in the sitting (Long Beach) or supine (Boston) posture, and the genioglossus electromyogram (EMGgg) was measured with an intraoral surface electrode (Long Beach) or intramuscular electrode (Boston). The response of the EMGgg was expressed as the percent change from baseline where the baseline EMGgg was the value at the onset of the NPA. In Long Beach, the EMGgg response was significantly higher in the OSA patients at a lower suction pressure of ∼10 cmH 2 O (75.2 ± 8.4 vs. 37.4 ± 4.0% increase; P < 0.001) but not at a higher suction pressure of ∼20 cmH 2 O. In Boston, the response in the OSA patients was also greater (107.2 ± 25.9 vs. 46.3 ± 8.3%; P < 0.05) at a suction pressure of ∼13 cmH 2 O. We conclude that the response of the genioglossus to NPA during wakefulness is not impaired in OSA patients compared with normal subjects and is greater at low suction pressures.

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  • A negative pressure reflex causes strong genioglossus activation when sub-atmospheric inspiratory pressure is applied.

    “A negative pressure reflex (NPR) exists whereby a sub-atmospheric (negative inspiratory or suction) pressure leads to a robust activation of the genioglossus muscle.”

    From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [390]

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Metadata

Authors
Berry, R. B., White, D. P., Roper, J., Pillar, G., Fogel, R. B., Stanchina, M., & Malhotra, A.
Affiliations
  • University of California, Irvine (US)
  • Brigham and Women's Hospital (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2003-05-01
Volume
94
Issue
5
Pages
1875-1882
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00324.2002
OpenAlex
W2057774958
Cited by
61
References
30
Citations by year
2025: 1 · 2023: 3 · 2022: 5 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 7
FWCI
0.77
Type
journal article
Language
en
Open access
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Heart, Lung, and Blood Institute (1 P50 HL 60292, T32-HL-07633, HL-48531, P50HL060292, R01HL048531, T32HL007633)
  • National Center for Research Resources (M01RR002635, MO1 RR 02635)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
Keywords
obstructive sleep apnea, genioglossus muscle, airway reflexes, supine position
MeSH terms
Adult, Air Pressure, Electrodes, Implanted, Electromyography, Female, Humans, Male, Middle Aged, Reflex, Respiratory Muscles, Wakefulness, Supine Position, Sleep Apnea, Obstructive

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