The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation
Open accessAbstract
Cardiovascular autonomic modulation during 36 h of total sleep deprivation (SD) was assessed in 18 normal subjects (16 men, 2 women, 26.0 +/- 4.6 yr old). ECG and continuous blood pressure (BP) from radial artery tonometry were obtained at 2100 on the first study night (baseline) and every subsequent 12 h of SD. Each measurement period included resting supine, seated, and seated performing computerized tasks and measured vigilance and executive function. Subjects were not supine in the periods between measurements. Spectral analysis of heart rate variability (HRV) and BP variability (BPV) was computed for cardiac parasympathetic modulation [high-frequency power (HF)], sympathetic modulation [low-frequency power (LF)], sympathovagal balance (LF/HF power of R-R variability), and BPV sympathetic modulation (at LF). All spectral data were expressed in normalized units [(total power of the components/total power-very LF) x 100]. Spontaneous baroreflex sensitivity (BRS), based on systolic BP and pulse interval powers, was also measured. Supine and sitting, BPV LF was significantly increased from baseline at 12, 24, and 36 h of SD. Sitting, HRV LF was increased at 12 and 24 h of SD, HRV HF was decreased at 12 h SD, and HRV LF/HF power of R-R variability was increased at 12 h of SD. BRS was decreased at 24 h of SD supine and seated. During the simple reaction time task (vigilance testing), the significantly increased sympathetic and decreased parasympathetic cardiac modulation and BRS extended through 36 h of SD. In summary, acute SD was associated with increased sympathetic and decreased parasympathetic cardiovascular modulation and decreased BRS, most consistently in the seated position and during simple reaction-time testing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This study also observed a significant increase in sympathetic modulation of BP variability and reduction in parasympathetic modulation of heart rate variability, which suggests increased sympathetic nervous activity.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
In the citing paper
“This study also observed a significant increase in sympathetic modulation of BP variability and reduction in parasympathetic modulation of heart rate variability, which suggests increased sympathetic nervous activity.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
In the citing paper
“Another study found no significant differences in SBP, DBP, or mean arterial pressure (MAP) after 36 hours of continuous sleep deprivation in 18 subjects seated in an upright position while the measurements were taken, but arterial baroreflex sensitivity significantly decreased [69].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
In the citing paper
“Another study found no significant differences in SBP, DBP, or mean arterial pressure (MAP) after 36 hours of continuous sleep deprivation in 18 subjects seated in an upright position while the measurements were taken, but arterial baroreflex sensitivity significantly decreased [69].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Longitudinal Data Analysis for Discrete and Continuous Outcomes
Zeger, S. L., & Liang, K. (1986) · Biometrics · doi:10.2307/2531248 · Cited by 7,781
Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R., Pizzinelli, P., Sandrone, G., Malfatto, G., Dell'Orto, S., & Piccaluga, E. (1986) · Circulation Research · doi:10.1161/01.res.59.2.178 · Cited by 4,130
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Cardiovascular neural regulation explored in the frequency domain.
Malliani, A., Pagani, M., Lombardi, F., & Cerutti, S. (1991) · Circulation · doi:10.1161/01.cir.84.2.482 · Cited by 3,569
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
Cited by
Sorted by citations
Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153
The role of sleep in emotional brain function
Goldstein, A. N., & Walker, M. P. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153716 · Cited by 1,052
“Congruently, sleep deprivation also increases sympathetic dominance of the autonomic nervous system, indexed by changes in heart rate variability (Sauvet et al 2010, Zhong et al 2005).”
BackgroundMeerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
Fullagar, H. H. K., Skorski, S., Duffield, R., Hammes, D., Coutts, A. J., & Meyer, T. (2014) · Sports Medicine · doi:10.1007/s40279-014-0260-0 · Cited by 1,087
Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
Mullington, J. M., Haack, M., Toth, M., Serrador, J. M., & Meier-Ewert, H. K. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.003 · Cited by 783
Metadata
- Authors
- Zhong, X., Hilton, H. J., Gates, G. J., Jelic, S., Stern, Y., Bartels, M. N., DeMeersman, R. E., & Basner, R. C.
- Affiliations
- Columbia University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-06
- Volume
- 98
- Issue
- 6
- Pages
- 2024-2032
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2112789469
- Cited by
- 468
- References
- 59
- Citations by year
- 2026: 10 · 2025: 27 · 2024: 18 · 2023: 30 · 2022: 32 · 2021: 27 · 2020: 22 · 2019: 27 · 2018: 26 · 2017: 27 · 2016: 24 · 2015: 26 · 2014: 21 · 2013: 26 · 2012: 29
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, cardiovascular autonomic modulation, sympathetic nervous system, parasympathetic nervous system, heart rate variability, blood pressure variability, baroreflex sensitivity, sympathovagal balance, sustained attention, reaction time, posture
- MeSH terms
- Adolescent, Adult, Blood Pressure, Female, Heart, Heart Rate, Hemostasis, Humans, Male, Parasympathetic Nervous System, Reference Values, Sleep Deprivation, Sympathetic Nervous System, Baroreflex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
