Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
Open accessAbstract
That insufficient sleep is associated with poor attention and performance deficits is becoming widely recognized. Fewer people are aware that chronic sleep complaints in epidemiologic studies have also been associated with an increase in overall mortality and morbidity. This article summarizes findings of known effects of insufficient sleep on cardiovascular risk factors including blood pressure, glucose metabolism, hormonal regulation, and inflammation with particular emphasis on experimental sleep loss, using models of total and partial sleep deprivation, in healthy individuals who normally sleep in the range of 7 to 8 hours and have no sleep disorders. These studies show that insufficient sleep alters established cardiovascular risk factors in a direction that is known to increase the risk of cardiac morbidity.
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Small-scale experimental studies have shown that short-term sleep deprivation may lead to metabolic dysregulation, elevated inflammation, and elevated blood pressure.
“Small-scale experimental studies have shown that short-term sleep deprivation may lead to metabolic dysregulation[29-34], elevated inflammation[35, 36], and elevated blood pressure[37].”
From Habitual sleep duration associated with self-reported and objectively determined cardiometabolic risk factors (2014) · cites this paper as [36]
Insufficient sleep (e.g., less than 4-6 h per night) increases the risk of death by suicide, mortality, cardiovascular disease, depression, diabetes, decreases immune system functioning, and has a negative impact on cognition.
“Insufficient sleep (e.g., less than 4–6 h per night) increases the risk of death by suicide [7,17], mortality, cardiovascular disease, depression, diabetes, decreases immune system functioning, and has a negative impact on cognition [14,18].”
From Mental Health of Canadian Firefighters: The Impact of Sleep (2021) · cites this paper as [18]
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- Authors
- Mullington, J. M., Haack, M., Toth, M., Serrador, J. M., & Meier-Ewert, H. K.
- Affiliations
- Boston University (US)
- Corresponding author
- Mullington, Janet M.
- Venue
- Progress in Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 51
- Issue
- 4
- Pages
- 294-302
- ISSN
- 0033-0620 (ISSN-L)
- PMC
- PMC3403737
- OpenAlex
- W2156599178
- Cited by
- 783
- References
- 76
- Citations by year
- 2026: 26 · 2025: 35 · 2024: 44 · 2023: 54 · 2022: 54 · 2021: 48 · 2020: 49 · 2019: 50 · 2018: 47 · 2017: 43 · 2016: 55 · 2015: 60 · 2014: 50 · 2013: 49 · 2012: 35
- FWCI
- 38.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (M01RR001032)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, insufficient sleep, cardiovascular risk factors, blood pressure, glucose metabolism, hormonal regulation, inflammation, sleep restriction, total sleep deprivation, mortality, cardiac morbidity
- MeSH terms
- Blood Glucose, Blood Pressure, Boston, C-Reactive Protein, Cardiovascular Diseases, Humans, Inflammation, Risk Factors, Sleep Deprivation, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Evidence-Based Medicine
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