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Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation
Open accessAbstract
Cardiovascular autonomic modulation during 36 h of total sleep deprivation (SD) was assessed in 18 normal subjects (16 men, 2 women, 26.0 +/- 4.6 yr old). ECG and continuous blood pressure (BP) from radial artery tonometry were obtained at 2100 on the first study night (baseline) and every subsequent 12 h of SD. Each measurement period included resting supine, seated, and seated performing computerized tasks and measured vigilance and executive function. Subjects were not supine in the periods between measurements. Spectral analysis of heart rate variability (HRV) and BP variability (BPV) was computed for cardiac parasympathetic modulation [high-frequency power (HF)], sympathetic modulation [low-frequency power (LF)], sympathovagal balance (LF/HF power of R-R variability), and BPV sympathetic modulation (at LF). All spectral data were expressed in normalized units [(total power of the components/total power-very LF) x 100]. Spontaneous baroreflex sensitivity (BRS), based on systolic BP and pulse interval powers, was also measured. Supine and sitting, BPV LF was significantly increased from baseline at 12, 24, and 36 h of SD. Sitting, HRV LF was increased at 12 and 24 h of SD, HRV HF was decreased at 12 h SD, and HRV LF/HF power of R-R variability was increased at 12 h of SD. BRS was decreased at 24 h of SD supine and seated. During the simple reaction time task (vigilance testing), the significantly increased sympathetic and decreased parasympathetic cardiac modulation and BRS extended through 36 h of SD. In summary, acute SD was associated with increased sympathetic and decreased parasympathetic cardiovascular modulation and decreased BRS, most consistently in the seated position and during simple reaction-time testing.
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“This study also observed a significant increase in sympathetic modulation of BP variability and reduction in parasympathetic modulation of heart rate variability, which suggests increased sympathetic nervous activity.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
In the citing paper
“This study also observed a significant increase in sympathetic modulation of BP variability and reduction in parasympathetic modulation of heart rate variability, which suggests increased sympathetic nervous activity.”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
In the citing paper
“Another study found no significant differences in SBP, DBP, or mean arterial pressure (MAP) after 36 hours of continuous sleep deprivation in 18 subjects seated in an upright position while the measurements were taken, but arterial baroreflex sensitivity significantly decreased [69].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
In the citing paper
“Another study found no significant differences in SBP, DBP, or mean arterial pressure (MAP) after 36 hours of continuous sleep deprivation in 18 subjects seated in an upright position while the measurements were taken, but arterial baroreflex sensitivity significantly decreased [69].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [69]
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“Congruently, sleep deprivation also increases sympathetic dominance of the autonomic nervous system, indexed by changes in heart rate variability (Sauvet et al 2010, Zhong et al 2005).”
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Metadata
- Authors
- Zhong, X., Hilton, H. J., Gates, G. J., Jelic, S., Stern, Y., Bartels, M. N., DeMeersman, R. E., & Basner, R. C.
- Affiliations
- Columbia University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-06
- Volume
- 98
- Issue
- 6
- Pages
- 2024-2032
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2112789469
- Cited by
- 468
- References
- 59
- Citations by year
- 2026: 10 · 2025: 27 · 2024: 18 · 2023: 30 · 2022: 32 · 2021: 27 · 2020: 22 · 2019: 27 · 2018: 26 · 2017: 27 · 2016: 24 · 2015: 26 · 2014: 21 · 2013: 26 · 2012: 29
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Columbia Academic Commons (Columbia University)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, cardiovascular autonomic modulation, sympathetic nervous system, parasympathetic nervous system, heart rate variability, blood pressure variability, baroreflex sensitivity, sympathovagal balance, sustained attention, reaction time, posture
- MeSH terms
- Adolescent, Adult, Blood Pressure, Female, Heart, Heart Rate, Hemostasis, Humans, Male, Parasympathetic Nervous System, Reference Values, Sleep Deprivation, Sympathetic Nervous System, Baroreflex
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