A role for brown adipose tissue in diet-induced thermogenesis

The Composition of Foods

McCance, R. A., & Widdowson, E. M. (1960) · Biblioteca Digital (Real Academia Nacional de Medicina) · Cited by 911 · see citing works

Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline

Foster, D. O., & Frydman, M. L. (1978) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y78-015 · Cited by 652 · see citing works

An easy colorimetric micromethod for routine determination of free fatty acids in plasma

Falholt, K., Lund, B., & FALHOLT, W. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90016-8 · Cited by 636 · see citing works

Dietary obesity in adult rats: Similarities to hypothalamic and human obesity syndromes

Sclafani, A. J., & Springer, D. (1976) · Physiology & Behavior · doi:10.1016/0031-9384(76)90109-8 · Cited by 616 · see citing works

The distribution of brown adipose tissue in the human.

Heaton, J. M. (1972) · PubMed · Cited by 606 · see citing works

The energy cost of fat and protein deposition in the rat

Pullar, J. D., & Webster, A. J. F. (1977) · British Journal Of Nutrition · doi:10.1079/bjn19770039 · Cited by 382 · see citing works

Stimulation of the sympathetic nervous system during sucrose feeding

Young, J. B., & Landsberg, L. (1977) · Nature · doi:10.1038/269615a0 · Cited by 334 · see citing works

Reduced thermogenesis in obesity

Jung, R. T., Shetty, P. S., James, W. P. T., Barrand, M. A., & Callingham, B. A. (1979) · Nature · doi:10.1038/279322a0 · Cited by 296 · see citing works

Cellular Thermogenesis

Himms‐Hagen, J. (1976) · Annual Review of Physiology · doi:10.1146/annurev.ph.38.030176.001531 · Cited by 282 · see citing works

Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse

Trayhurn, P., & James, W. P. T. (1978) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584859 · Cited by 257 · see citing works

Gluttony

Miller, D. S., MUMFORD, P., & Stock, M. J. (1967) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/20.11.1223 · Cited by 251 · see citing works

Effect of caloric restriction and excessive caloric intake on energy expenditure

Apfelbaum, M., Bostsarron, J., & Lacatîş, D. (1971) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/24.12.1405 · Cited by 232 · see citing works

Weight Maintenance and Food Intake

Miller, D. S., & Payne, P. (1962) · Journal of Nutrition · doi:10.1093/jn/78.3.255 · Cited by 230 · see citing works

Role of the Sympathetic Nervous System in the Control of Chemical Regulation of Heat Production

Hsieh, A. C. L., Carlson, L. D., & Gray, G. M. (1957) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1957.190.2.247 · Cited by 230 · see citing works

A mitochondrial defect in brown adipose tissue of the obese (obob) mouse: Reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding

Himms‐Hagen, J., & Desautels, M. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91036-7 · Cited by 210 · see citing works

An automatic, closed-circuit oxygen consumption apparatus for small animals

Stock, M. J. (1975) · Journal of Applied Physiology · doi:10.1152/jappl.1975.39.5.849 · Cited by 138 · see citing works

Obesity in perspective

Bray, G. A. (1975) · Cited by 132 · see citing works

Throxine and noradrenaline on noradrenaline sensitivity, cold resistance, and brown fat

LEBLANC, J., & Villemaire, A. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.218.6.1742 · Cited by 115 · see citing works

The regulation of the adipose tissue mass.

Vague, J., & Boyer, J. (1974) · Cited by 114 · see citing works

Metabolic Origins of Thermogenesis induced by Diet

Stirling, J. L., & Stock, M. J. (1968) · Nature · doi:10.1038/220801a0 · Cited by 105 · see citing works

Development of obesity in diabetic mice pair-fed with lean siblings.

Cox, J. E., & Powley, T. L. (1977) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077322 · Cited by 95 · see citing works

The Occurrence of Brown Adipose Tissue in Perirenal Fat in Japanese

TANUMA, Y., Yamamoto, M., Ito, T., & Yokochi, C. (1975) · Archivum histologicum japonicum · doi:10.1679/aohc1950.38.43 · Cited by 86 · see citing works

Dynamics of Growth Processes

Osmanov, R. M., & Anatov, D. M. (1954) · AIBS Bulletin · doi:10.1093/aibsbulletin/4.3.12-e · Cited by 73 · see citing works

Dynamics of Growth Processes

Steward, F. C., & Boell, E. J. (1955) · Ecology · doi:10.2307/1931453 · Cited by 58 · see citing works

Acclimation of the white rat to cold: noradrenaline thermogenesis.

Janský, L., Bartůnková, R., & Zeisberger, E. (1967) · PubMed · Cited by 55 · see citing works

Time-dependent responses of brown fat in cold-exposed rats

Roberts, J., & Smith, R. (1967) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1967.212.2.519 · Cited by 52 · see citing works

In vivo determination of body composition by tritium dilution in the rat

Rothwell, N. J., & Stock, M. J. (1979) · British Journal Of Nutrition · doi:10.1079/bjn19790078 · Cited by 41 · see citing works

Thermoregulation in genetically obese rodents: the relationship to metabolic efficiency

Trayhurn, P., Thurlby, P. L., Woodward, C. J. H., & James, W. P. T. (1979) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-04201-2_12 · Cited by 18 · see citing works

Energy balance in reversible obesity

Stock, M. J., & Rothwell, N. J. (1979) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-04201-2_9 · Cited by 15 · see citing works

BROWN ADIPOSE TISSUE

Aherne, W., & Hull, D. (1965) · The Lancet · doi:10.1016/s0140-6736(65)92125-2 · Cited by 5 · see citing works

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

What we talk about when we talk about fat

Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Butyrate improves insulin sensitivity and increases energy expenditure in mice

Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works

Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator

Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076 · see citing works

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630 · see citing works

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379 · see citing works

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

Liesa, M., & Shirihai, O. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.002 · Cited by 1,341 · see citing works

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works

PGC-1α: a key regulator of energy metabolism

Liang, H., & Ward, W. F. (2006) · AJP Advances in Physiology Education · doi:10.1152/advan.00052.2006 · Cited by 1,250 · see citing works

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235 · see citing works

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

Manna, P., & Jain, S. K. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0095 · Cited by 1,167 · see citing works

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works

Brown and Beige Fat: Physiological Roles beyond Heat Generation

Kajimura, S., Spiegelman, B. M., & Seale, P. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.007 · Cited by 1,004 · see citing works

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 884 · see citing works

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 806 · see citing works

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

Chouchani, E. T., Kazak, L., & Spiegelman, B. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.11.002 · Cited by 797 · see citing works

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782 · see citing works

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

Arch, J. R. S., Ainsworth, A. T., Cawthorne, M. A., Piercy, V., Sennitt, M. V., Thody, V. E., Wilson, C., & Wilson, S. (1984) · Nature · doi:10.1038/309163a0 · Cited by 728 · see citing works

UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue

Vidal‐Puig, A., Solanes, G., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6740 · Cited by 711 · see citing works

Control of brown and beige fat development

Wang, W., & Seale, P. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.96 · Cited by 697 · see citing works

Nonshivering thermogenesis and its adequate measurement in metabolic studies

Cannon, B., & Nedergaard, J. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.050989 · Cited by 677 · see citing works

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665 · see citing works

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635 · see citing works

Energy source, protein metabolism, and hunter-gatherer subsistence strategies

Speth, J. D., & Spielmann, K. A. (1983) · Journal of Anthropological Archaeology · doi:10.1016/0278-4165(83)90006-5 · Cited by 612 · see citing works

Cellular bioenergetics as a target for obesity therapy

Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works

Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β3-Adrenergic–Receptor Gene

Walston, J. D., Silver, K. D., Bogardus, C., Knowler, W. C., Celi, F. S., Austin, S., Manning, B. S., Strosberg, A. D., D, M. P. S. M., Raben, N., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508103330603 · Cited by 587 · see citing works

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553 · see citing works

Thermal biology of the laboratory rat

Gordon, C. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90025-y · Cited by 521 · see citing works

Role of leptin in fat regulation

Collins, S., Kuhn, C. M., Petro, A. E., Swick, A. G., Chrunyk, B. A., & Surwit, R. S. (1996) · Nature · doi:10.1038/380677a0 · Cited by 520 · see citing works

Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region

Hany, T. F., Gharehpapagh, E., Kamel, E. M., Buck, A., Himms-Hagen, J., & von Schulthess, G. K. (2002) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-0902-6 · Cited by 511 · see citing works

Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics

Collins, S., Martin, T. L., Surwit, R. S., & Robidoux, J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.006 · Cited by 486 · see citing works

Acquirement of brown fat cell features by human white adipocytes

Tiraby, C., Tavernier, G., Lefort, C., Larrouy, D., Bouillaud, F., Ricquier, D., & Langin, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305235200 · Cited by 474 · see citing works

Sympathetic and sensory innervation of brown adipose tissue

Bartness, T. J., Vaughan, C. H., & Song, C. K. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.182 · Cited by 459 · see citing works

Integrative models of nutrient balancing: application to insects and vertebrates

Raubenheimer, D., & Simpson, S. J. (1997) · Nutrition Research Reviews · doi:10.1079/nrr19970009 · Cited by 454 · see citing works

mTOR as a central regulator of lifespan and aging

Papadopoli, D. J., Boulay, K., Kazak, L., Pollak, M., Mallette, F. A., Topisirović, I., & Hulea, L. (2019) · F1000Research · doi:10.12688/f1000research.17196.1 · Cited by 431 · see citing works

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7356 · Cited by 428 · see citing works

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

Kajimura, S., & Saito, M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170252 · Cited by 428 · see citing works

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

Cummings, D. E., Brandon, E. P., Planas, J. V., Motamed, K., Idzerda, R. L., & McKnight, G. S. (1996) · Nature · doi:10.1038/382622a0 · Cited by 418 · see citing works

Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism

Billington, C. J., Briggs, J. E., Grace, M. K., & Levine, A. S. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.2.r321 · Cited by 412 · see citing works

Adrenergic activation of triiodothyronine production in brown adipose tissue

Silva, J. E., & Larsen, P. R. (1983) · Nature · doi:10.1038/305712a0 · Cited by 401 · see citing works

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.022 · Cited by 398 · see citing works

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

Harms, M. J., Ishibashi, J., Wang, W., Lim, H., Goyama, S., Sato, T., Kurokawa, M., Won, K., & Seale, P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.007 · Cited by 385 · see citing works

Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3

Gong, D., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Chou, C. J., Everett, C. A., Kozak, L. P., Li, C., Deng, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910177199 · Cited by 385 · see citing works

Diet, Obesity and Hypertension: An Hypothesis Involving Insulin, the Sympathetic Nervous System, and Adaptive Thermogenesis

LANDSBERG, L. (1986) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068066 · Cited by 373 · see citing works

Regulation of Body Weight in Humans

Jéquier, E., & Tappy, L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.451 · Cited by 369 · see citing works

Human Brown Adipose Tissue

Enerbäck, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.008 · Cited by 371 · see citing works

EBF2 Determines and Maintains Brown Adipocyte Identity

Rajakumari, S., Wu, J., Ishibashi, J., Lim, H., Giang, A.-H., Won, K., Reed, R. R., & Seale, P. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.015 · Cited by 367 · see citing works

Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

Ziętak, M., Kovatcheva‐Datchary, P., Markiewicz, L. H., Ståhlman, M., Kozak, L. P., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.001 · Cited by 354 · see citing works

Effect of Diet and Cold Exposure on Norepinephrine Turnover in Brown Adipose Tissue of the Rat

Young, J. B., Saville, E., Rothwell, N. J., Stock, M. J., & Landsberg, L. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110541 · Cited by 356 · see citing works

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 343 · see citing works

Natural rewards, neuroplasticity, and non-drug addictions

Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339 · see citing works

The eating paradox: How we tolerate food.

Woods, S. C. (1991) · Psychological Review · doi:10.1037/0033-295x.98.4.488 · Cited by 337 · see citing works

Dietary variety, energy regulation, and obesity.

Raynor, H. A., & Epstein, L. H. (2001) · Psychological Bulletin · doi:10.1037/0033-2909.127.3.325 · Cited by 332 · see citing works

Energy intake and other determinants of relative weight

Romieu, I., Willett, W. C., Stampfer, M. J., Colditz, G. A., Sampson, L., ROSNER, B. A., Hennekens, C. H., & Fe, S. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.3.406 · Cited by 333 · see citing works

Brown fat fuel utilization and thermogenesis

Townsend, K. L., & Tseng, Y. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.004 · Cited by 331 · see citing works

Severely Impaired Adipsin Expression in Genetic and Acquired Obesity

Flier, J. S., Cook, K. S., Usher, P., & Spiegelman, B. M. (1987) · Science · doi:10.1126/science.3299706 · Cited by 329 · see citing works

Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus

Perkins, M., Rothwell, N. J., Stock, M. J., & Stone, T. W. (1981) · Nature · doi:10.1038/289401a0 · Cited by 326 · see citing works

BODY FAT, PUBERTY AND FERTILITY

Frisch, R. E. (1984) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1984.tb00406.x · Cited by 313 · see citing works

Implications of nonshivering thermogenesis for energy balance regulation in humans

Lichtenbelt, W. D. V. M., & Schrauwen, P. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00652.2010 · Cited by 306 · see citing works

Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice

Surwit, R. S., Wang, S., Petro, A. E., Sanchı́s, D., Raimbault, S., Ricquier, D., & Collins, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4061 · Cited by 311 · see citing works

The dorsomedial hypothalamic nucleus revisited: 1986 update

Bernardis, L. L., & Bellinger, L. L. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90004-x · Cited by 309 · see citing works

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

Li, B., Li, L., Li, M., Lam, S. M., Wang, G., Wu, Y., Zhang, H., Niu, C., Zhang, X., Liu, X., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.015 · Cited by 302 · see citing works

An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity.

Muzzin, P., Revelli, J. P., Kühne, F., Gocayne, J. D., McCombie, W. R., Venter, J. C., Giacobino, J.-P., & Fraser, C. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54391-x · Cited by 294 · see citing works

Development of insulin resistance in mice lacking PGC-1α in adipose tissues

Kleiner, S., Mepani, R. J., Laznik, D., Li, Y., Jurczak, M. J., Jornayvaz, F. R., Estall, J. L., Bhowmick, D. C., Shulman, G. I., & Spiegelman, B. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207287109 · Cited by 286 · see citing works

Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet

Shimomura, Y., Tamura, T., & Suzuki, M. (1990) · The Journal of Nutrition · doi:10.1093/jn/120.11.1291 · Cited by 287 · see citing works

Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat

Xue, B., Rim, J.-S., Hogan, J. C., Coulter, A. A., Koza, R. A., & Kozak, L. P. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600287-jlr200 · Cited by 288 · see citing works

Photoperiodic control of seasonal body weight cycles in hamsters

Bartness, T. J., & Wade, G. N. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90006-5 · Cited by 286 · see citing works

Wasting in chronic kidney disease

Mak, R. H., Ikizler, A. T., Kovesdy, C. P., Raj, D. S., Stenvinkel, P., & Kalantar-Zadeh, K. (2011) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-011-0019-5 · Cited by 281 · see citing works

Paradoxical resistance to diet-induced obesity in UCP1-deficient mice

Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315737 · Cited by 281 · see citing works

Strain-Specific Response toβ3-Adrenergic Receptor Agonist Treatment of Diet-Induced Obesity in Mice1

Collins, S., Daniel, K. W., Petro, A. E., & Surwit, R. S. (1997) · Endocrinology · doi:10.1210/endo.138.1.4829 · Cited by 265 · see citing works

Paradoxical resistance to diet-induced obesity in UCP1-deficient mice

Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15737 · Cited by 265 · see citing works

Creatine metabolism: energy homeostasis, immunity and cancer biology

Kazak, L., & Cohen, P. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0365-5 · Cited by 260 · see citing works

Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction

Malloy, V. L., Krajcik, R. A., Bailey, S. J., Hristopoulos, G., Plummer, J. D., & Orentreich∥, N. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00220.x · Cited by 266 · see citing works

The uncoupling proteins, a review

Boss, O., Muzzin, P., & Giacobino, J.-P. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390001 · Cited by 264 · see citing works

A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes

Butler, A. A., & Kozak, L. P. (2010) · Diabetes · doi:10.2337/db09-1471 · Cited by 263 · see citing works

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

Sharma, A., & Rudra, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00883 · Cited by 263 · see citing works

Sympathetic system activity in obesity and metabolic syndrome

TENTOLOURIS, N., LIATIS, S., & KATSILAMBROS, N. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.010 · Cited by 260 · see citing works

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

Kazak, L., Chouchani, E. T., Lu, G. Z., Jedrychowski, M. P., Bare, C. J., Mina, A. I., Kumari, M., Zhang, S., Vučković, I., Laznik-Bogoslavski, D., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.009 · Cited by 262 · see citing works

Adrenergic regulation of adipocyte metabolism.

Fain, J. N., & García-Sáinz, J. A. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37910-4 · Cited by 262 · see citing works

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

Sellayah, D., Bharaj, P., & Sikder, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.010 · Cited by 259 · see citing works

Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline

THOMAS, S. A., & Palmiter, R. D. (1997) · Nature · doi:10.1038/387094a0 · Cited by 258 · see citing works

Energy expenditure and postprandial thermogenesis in obese women before and after weight loss

Bessard, T., Schutz, Y., & Jéquier, E. (1983) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/38.5.680 · Cited by 257 · see citing works

The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism

Bernardis, L. L., & Bellinger, L. L. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80149-6 · Cited by 247 · see citing works

Leptin-Receptor-Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits

Zhang, Y., Kerman, I. A., Laque, A., Nguyen, P., Faouzi, M., Louis, G. W., Jones, J. C., Rhodes, C. J., & Münzberg, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3223-10.2011 · Cited by 240 · see citing works

Contributions of white and brown adipose tissues and skeletal muscles to acute cold‐induced metabolic responses in healthy men

Blondin, D. P., Labbé, S. M., Phoenix, S., Guérin, B., Turcotte, É. E., Richard, D., Carpentier, A. C., & Haman, F. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.283598 · Cited by 245 · see citing works

Brown Fat and the Myth of Diet-Induced Thermogenesis

Kozak, L. P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.009 · Cited by 243 · see citing works

Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men

Saito, M., Matsushita, M., Yoneshiro, T., & Okamatsu‐Ogura, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00222 · Cited by 241 · see citing works

Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man

Astrup, A. V., Bülow, J., Madsen, J., & Christensen, N. J. (1985) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1985.248.5.e507 · Cited by 241 · see citing works

Nonshivering thermogenesis

Himms‐Hagen, J. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90183-7 · Cited by 238 · see citing works

BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY

Lowell, M., & Flier, M. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.307 · Cited by 237 · see citing works

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

Cero, C., Lea, H. J., ZHU, K. Y., Shamsi, F., Tseng, Y., & Cypess, A. M. (2021) · JCI Insight · doi:10.1172/jci.insight.139160 · Cited by 237 · see citing works

Body-weight regulation: causes of obesity

Martínez, J. A. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000380 · Cited by 236 · see citing works

Apelin, an APJ Receptor Ligand, Regulates Body Adiposity and Favors the Messenger Ribonucleic Acid Expression of Uncoupling Proteins in Mice

Higuchi, K., Masaki, T., Gotoh, K., Chiba, S., Katsuragi, I., Tanaka, K., Kakuma, T., & Yoshimatsu, H. (2007) · Endocrinology · doi:10.1210/en.2006-1270 · Cited by 235 · see citing works

Convertible visceral fat as a therapeutic target to curb obesity

Giordano, A., Frontini, A., & Cinti, S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.31 · Cited by 232 · see citing works

Thermogenesis in Brown Adipose Tissue as an Energy Buffer

Flier, J. S., Underhill, L. H., & Himms‐Hagen, J. (1984) · New England Journal of Medicine · doi:10.1056/nejm198412133112407 · Cited by 234 · see citing works

Thermic effect of feeding in man: Increased plasma norepinephrine levels following glucose but not protein or fat consumption

Welle, S. L., Lilavivat, U., & Campbell, R. G. (1981) · Metabolism · doi:10.1016/0026-0495(81)90092-5 · Cited by 233 · see citing works

Is there a sympathetic regulation of the efficiency of energy utilization?

Girardier, L., & Seydoux, J. (1981) · PubMed · Cited by 11 · see citing works

Brown adipose tissue thermogenesis, energy balance, and obesity

Himms‐Hagen, J. (1984) · Canadian Journal of Biochemistry and Cell Biology · doi:10.1139/o84-081 · Cited by 55 · see citing works

Regulation of thermogenesis in obesity.

Levin, B. E., & Sullivan, A. C. (1984) · PubMed · Cited by 8 · see citing works

The role of thermogenesis in the regulation of energy balance

Richard, D. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-059

The role of brown fat in diet-induced thermogenesis.

Stock, M. J., & Rothwell, N. J. (1986) · PubMed · Cited by 18 · see citing works