Ventilatory and perceptual responses to cycle exercise in obese women
Abstract
The main purpose of this study was to examine the relative contribution of respiratory mechanical factors and the increased metabolic cost of locomotion to exertional breathlessness in obese women. We examined the relationship of intensity of breathlessness to ventilation (V̇e) when exertional oxygen uptake (V̇o 2 ) of obesity was minimized by cycle exercise. Eighteen middle-aged (54 ± 8 yr, mean ± SD) obese [body mass index (BMI) 40.2 ± 7.8 kg/m 2 ] and 13 age-matched normal-weight (BMI 23.3 ± 1.7 kg/m 2 ) women were studied. Breathlessness at higher submaximal cycle work rates was significantly increased (by ≥1 Borg unit) in obese compared with normal-weight women, in association with a 35–45% increase in V̇e and a higher metabolic cost of exercise. Obese women demonstrated greater resting expiratory flow limitation, reduced resting end-expiratory lung volume (EELV)(by 20%), and progressive increases in dynamic EELV during exercise: peak inspiratory capacity (IC) decreased by 16% (0.39 liter) of the resting value. V̇e/V̇o 2 slopes were unchanged in obesity. Breathlessness ratings at any given V̇e or V̇o 2 were not increased in obesity, suggesting that respiratory mechanical factors were not contributory. Our results indicate that in obese women, recruitment of resting IC and dynamic increases in EELV with exercise served to optimize operating lung volumes and to attenuate expiratory flow limitation so as to accommodate the increased ventilatory demand without increased breathlessness.
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Added weight on the thorax and abdomen (and also the neck) can significantly affect static and dynamic lung volumes along with respiratory mechanics, usually in a dose-response fashion.
“Added weight on the thorax and abdomen (and also the neck), can significantly affect static and dynamic lung volumes along with respiratory mechanics,92–112 usually in a dose-response fashion.”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [97]
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Self-citationDistinguishable Types of Dyspnea in Patients with Shortness of Breath
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Where Does Sherrington's "Muscular Sense" Originate? Muscles, Joints, Corollary Discharges?
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“Leg discomfort may simply reflect the higher contractile muscle effort and central motor command output required to mobilize the heavy limbs (20, 34).”
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Pathogenesis of hyperinflation in chronic obstructive pulmonary disease
Saey, Gagnon, P., Guenette, J., Langer, D., Laviolette, L., Mainguy, V., Maltais, F., & Ribeiro, F. (2014) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s38934 · Cited by 180 · see citing works
Ora, J., Laveneziana, P., Ofir, D., Deesomchok, A., Webb, K. A., & O'Donnell, D. E. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200904-0530oc · Cited by 139 · see citing works
Self-citationEffect of obesity on respiratory mechanics during rest and exercise in COPD
Ora, J., Laveneziana, P., Wadell, K., Preston, M., Webb, K. A., & O'Donnell, D. E. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01131.2010 · Cited by 101 · see citing works
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Weight Loss via Diet and Exercise Improves Exercise Breathing Mechanics in Obese Men
Babb, T. G., Wyrick, B. L., Chase, P. J., DeLorey, D. S., Rodder, S. G., Feng, M. Y., & Ranasinghe, K. G. (2011) · Chest · doi:10.1378/chest.10-1088 · Cited by 60 · see citing works
Vaes, A. W., Franssen, F. M. E., Meijer, K., Cuijpers, M. W. J., Wouters, E. F. M., Rutten, E. P. A., & Spruit, M. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041078 · Cited by 8 · see citing works
- Authors
- Ofir, D., Laveneziana, P., Webb, K. A., & O'Donnell, D. E.
- Affiliations
- Queen's University (CA)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2007-06
- Volume
- 102
- Issue
- 6
- Pages
- 2217-2226
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2116988580
- Cited by
- 176
- References
- 5
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 10 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 19
- FWCI
- 38.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- obesity, exertional dyspnea, ventilatory response, respiratory mechanics, expiratory flow limitation, end-expiratory lung volume, inspiratory capacity, metabolic cost of locomotion, cycling exercise, oxygen consumption, Borg scale, middle-aged women
- MeSH terms
- Adult, Aged, Aged, 80 and over, Dyspnea, Exercise Test, Physical Exertion, Female, Humans, Middle Aged, Models, Biological, Obesity, Oxygen, Oxygen Consumption, Respiratory Mechanics
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