The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
Abstract
The brain is critically dependent on a continuous supply of blood to function. Therefore, the cerebral vasculature is endowed with neurovascular control mechanisms that assure that the blood supply of the brain is commensurate to the energy needs of its cellular constituents. The regulation of cerebral blood flow (CBF) during brain activity involves the coordinated interaction of neurons, glia, and vascular cells. Thus, whereas neurons and glia generate the signals initiating the vasodilation, endothelial cells, pericytes, and smooth muscle cells act in concert to transduce these signals into carefully orchestrated vascular changes that lead to CBF increases focused to the activated area and temporally linked to the period of activation. Neurovascular coupling is disrupted in pathological conditions, such as hypertension, Alzheimer disease, and ischemic stroke. Consequently, CBF is no longer matched to the metabolic requirements of the tissue. This cerebrovascular dysregulation is mediated in large part by the deleterious action of reactive oxygen species on cerebral blood vessels. A major source of cerebral vascular radicals in models of hypertension and Alzheimer disease is the enzyme NADPH oxidase. These findings, collectively, highlight the importance of neurovascular coupling to the health of the normal brain and suggest a therapeutic target for improving brain function in pathologies associated with cerebrovascular dysfunction.
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Citations
Cites
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Self-citationPatterns of Brain Activation in People at Risk for Alzheimer's Disease
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Cerebral microvascular pathology in aging and Alzheimer's disease
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Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
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Self-citationOxidative Stress in Hypertension
de Champlain, J., Wu, R., Girouard, H., Karas, M., EL Midaoui, A., Laplante, M., & Wu, L. (2004) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200031904 · Cited by 208
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Self-citationAβ-peptides enhance vasoconstriction in cerebral circulation
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Self-citationReduced cerebral blood flow response and compensation among patients with untreated hypertension
Jennings, J. R., Muldoon, M. F., Ryan, C., Price, J. C., Greer, P., Sutton-Tyrrell, K., van der Veen, F. M., & Meltzer, C. C. (2005) · Neurology · doi:10.1212/01.wnl.0000158283.28251.3c · Cited by 198 · cited 3×
“The increase in CBF in posterior parietal and thalamic areas produced by cognitive tasks is reduced in patients with chronic untreated hypertension relative to normotensive individuals (37).”
Background
Cited by
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486
Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., & Lo, E. H. (2009) · Stroke · doi:10.1161/strokeaha.108.541128 · Cited by 1,352
Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis
Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882
Metadata
- Authors
- Girouard, H., & Iadecola, C.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2006-01
- Volume
- 100
- Issue
- 1
- Pages
- 328-335
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2104591424
- Cited by
- 1,265
- References
- 12
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- closed
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