Cited by 687Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

Cai, Hua, Griendling, Kathy K, Harrison, David G·2003·Trends in Pharmacological Sciences

Abstract

Activation of vascular NAD(P)H oxidases and the production of reactive oxygen species (ROS) by these enzyme systems are common in cardiovascular disease. In the past several years, a new family of NAD(P)H oxidase subunits, known as the non-phagocytic NAD(P)H oxidase (NOX) proteins, have been discovered and shown to play a role in vascular tissues. Recent studies make clearer the mechanisms of activation of the endothelial and vascular smooth muscle NAD(P)H oxidases. ROS produced following angiotensin II-mediated stimulation of NAD(P)H oxidases signal through pathways such as mitogen-activated protein kinases, tyrosine kinases and transcription factors, and lead to events such as inflammation, hypertrophy, remodeling and angiogenesis. Studies in mice that are deficient in p47(phox) and gp91(phox) (also known as NOX2) NAD(P)H oxidase subunits show that ROS produced by these oxidases contribute to cardiovascular diseases including atherosclerosis and hypertension. Recently, efforts have been devoted to developing inhibitors of NAD(P)H oxidases that will provide useful experimental tools and might have therapeutic potential in the treatment of human diseases.

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Crossref · 10.1016/s0165-6147(03)00233-5

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84 of 84 references verified0 citation errors · 0 not checkable

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  • Increased NOX2 activity is linked to vascular disease.

    “The current knowledge about NOX enzymes in the cardiovascular system indicates that NOX2 is usually the main player in the development of pathological conditions and increased NOX2 activity is linked to vascular disease (142, 252, 478).”
  • Current knowledge about NOX enzymes in the cardiovascular system indicates that NOX2 is usually the main player in the development of pathological conditions.

    “The current knowledge about NOX enzymes in the cardiovascular system indicates that NOX2 is usually the main player in the development of pathological conditions and increased NOX2 activity is linked to vascular disease (142, 252, 478).”

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Authors
Cai, H., Griendling, K. K., & Harrison, D. G.
Affiliations
Emory University (US)
Corresponding author
Harrison, David G
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2003-09
Volume
24
Issue
9
Pages
471-478
ISSN
0165-6147 (ISSN-L)
OpenAlex
W2000155150
Cited by
687
References
84
Citations by year
2026: 6 · 2025: 5 · 2024: 13 · 2023: 3 · 2022: 9 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 13 · 2017: 10 · 2016: 26 · 2015: 25 · 2014: 32 · 2013: 35 · 2012: 47
FWCI
8.02
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
NADPH oxidase, reactive oxygen species, cardiovascular disease, p47phox, gp91phox, NOX2, angiotensin II, vascular smooth muscle, atherosclerosis, hypertension, therapeutic target, inflammation, vascular remodeling, angiogenesis
MeSH terms
Angiotensin II, Animals, Blood Vessels, Cardiovascular Agents, Cardiovascular Diseases, Enzyme Activation, Humans, Reactive Oxygen Species, NADPH Oxidases, Mice

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