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Cited by 178Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchConnexins and lens biology

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Carbenoxolone Inhibition of Voltage-Gated Ca Channels and Synaptic Transmission in the Retina

Vessey, John P., Lalonde, Melanie R., Mizan, Hossein A., Welch, Nicole C., Kelly, Melanie E. M., Barnes, Steven·2004·Journal of Neurophysiology
DOI 10.1152/jn.00148.2004
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Abstract

We show that carbenoxolone, a drug used to block hemichannels in the retina to test the ephaptic model of horizontal cell inhibitory feedback, has strong inhibitory effects on voltage-gated Ca channels. Carbenoxolone (100 μM) reduced photoreceptor-to-horizontal cell synaptic transmission by 92%. Applied to patch-clamped, isolated cone photoreceptors, carbenoxolone inhibited Ca channels with an EC 50 of 48 μM. At 100 μM, it reduced cone Ca channel current by 37%, reduced depolarization-evoked [Ca 2+ ] signals in fluo-4 loaded retinal slices by 57% and inhibited Ca channels in Müller cells by 52%. A synaptic transfer model suggests that the degree of block of Ca channels accounts for the reduction in synaptic transmission. These results suggest broad inhibitory actions for carbenoxolone in the retina that must be considered when interpreting its effects on inhibitory feedback.

Overview

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Crossref · 10.1152/jn.00148.2004

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24 of 24 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Vessey, J. P., Lalonde, M. R., Mizan, H. A., Welch, N. C., Kelly, M. E. M., & Barnes, S.
Affiliations
Dalhousie University (CA)
ORCID
Barnes, Steven
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2004-08
Volume
92
Issue
2
Pages
1252-1256
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00148.2004
OpenAlex
W2010736218
Cited by
178
References
24
Citations by year
2026: 5 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 11 · 2015: 6 · 2014: 10 · 2013: 8 · 2012: 16
FWCI
4.38
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords
carbenoxolone, voltage-gated calcium channels, synaptic transmission, retina, horizontal cells, photoreceptors, Müller cells, hemichannels, calcium channel inhibition, cone photoreceptors
MeSH terms
Ambystoma, Aniline Compounds, Animals, Calcium Channel Blockers, Carbenoxolone, Electrophysiology, Fluorescent Dyes, Larva, Neural Inhibition, Synaptic Transmission, Retina, Xanthenes, Calcium Channels, Retinal Cone Photoreceptor Cells, Patch-Clamp Techniques, Photoreceptor Cells, Vertebrate, In Vitro Techniques

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.