Cited by 178Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchConnexins and lens biology

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Carbenoxolone Inhibition of Voltage-Gated Ca Channels and Synaptic Transmission in the Retina

Vessey, John P., Lalonde, Melanie R., Mizan, Hossein A., Welch, Nicole C., Kelly, Melanie E. M., Barnes, Steven·2004·Journal of Neurophysiology

DOI 10.1152/jn.00148.2004

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Abstract

We show that carbenoxolone, a drug used to block hemichannels in the retina to test the ephaptic model of horizontal cell inhibitory feedback, has strong inhibitory effects on voltage-gated Ca channels. Carbenoxolone (100 μM) reduced photoreceptor-to-horizontal cell synaptic transmission by 92%. Applied to patch-clamped, isolated cone photoreceptors, carbenoxolone inhibited Ca channels with an EC 50 of 48 μM. At 100 μM, it reduced cone Ca channel current by 37%, reduced depolarization-evoked [Ca 2+ ] signals in fluo-4 loaded retinal slices by 57% and inhibited Ca channels in Müller cells by 52%. A synaptic transfer model suggests that the degree of block of Ca channels accounts for the reduction in synaptic transmission. These results suggest broad inhibitory actions for carbenoxolone in the retina that must be considered when interpreting its effects on inhibitory feedback.

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McCormick, D. A., & Contreras, D. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.815 · Cited by 1,005
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Modulation of transmission gain by protons at the photoreceptor output synapse.
Barnes, S., Merchant, V., & Mahmud, F. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10081 · Cited by 163
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Prolonged epileptiform bursting induced by 0-Mg2+ in rat hippocampal slices depends on gap junctional coupling
Köhling, R., Gladwell, S. J., Bracci, E., Vreugdenhil, M., & Jefferys, J. G. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00222-6 · Cited by 152
Ionic currents of solitary horizontal cells isolated from goldfish retina.
Tachibana, M. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014981 · Cited by 144
Surround Antagonism in Macaque Cone Photoreceptors
Verweij, J., Hornstein, E. P., & Schnapf, J. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10249.2003 · Cited by 144
Light-dependent change of cone-horizontal cell interactions in carp retina
Weiler, R., & Wagner, H.-J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91141-7 · Cited by 125
EXCITATORY AND INHIBITORY SYNAPTIC MECHANISMS IN ANAESTHESIA
Pocock, G., & Richards, C. D. (1993) · British Journal of Anaesthesia · doi:10.1093/bja/71.1.134 · Cited by 117

Show all 24 references

Mechanisms underlying spontaneous patterned activity in developing neural circuits
Blankenship, A. G., & Feller, M. B. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2759 · Cited by 851
P2X7Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+Signaling
Suadicani, S. O., Brosnan, C. F., & Scemes, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3902-05.2006 · Cited by 512
Perisomatic Feedback Inhibition Underlies Cholinergically Induced Fast Network Oscillations in the Rat Hippocampus In Vitro
Mann, E. O., Suckling, J. M., Hajos, N., Greenfield, S. A., & Paulsen, O. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.016 · Cited by 318
Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions
Luhmann, H. J., Sinning, A., Yang, J.-W., Reyes-Puerta, V., Stüttgen, M. C., Kirischuk, S., & Kilb, W. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00040 · Cited by 271
Lateral interactions in the outer retina
Thoreson, W. B., & Mangel, S. C. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.04.003 · Cited by 262
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications
Leybaert, L., Lampe, P. D., Dhein, S., Kwak, B. R., Ferdinandy, P., Beyer, E. C., Laird, D. W., Naus, C. C. G., Green, C. R., & Schulz, R. (2017) · Pharmacological Reviews · doi:10.1124/pr.115.012062 · Cited by 248
Physiologic Diversity and Development of Intrinsically Photosensitive Retinal Ganglion Cells
Tu, D. C., Zhang, D., Demas, J., Slutsky, E. B., Provencio, I., Holy, T. E., & Gelder, R. N. V. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.031 · Cited by 242
Synaptic transmission at retinal ribbon synapses
Heidelberger, R., Thoreson, W. B., & Witkovsky, P. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2005.04.002 · Cited by 239
Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: Animal and human studies
Juszczak, G. R., & Swiergiel, A. H. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.014 · Cited by 211
The participation of plasma membrane hemichannels to purinergic signaling
Baroja‐Mazo, A., Barberà-Cremades, M., & Pelegrín, P. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.01.002 · Cited by 178
Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina
Thoreson, W. B., & Dacey, D. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00027.2018 · Cited by 171
Inhibitors of connexin and pannexin channels as potential therapeutics
Willebrords, J., Maes, M., Yanguas, S. C., & Vinken, M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.07.001 · Cited by 164
Hippocampal gamma‐frequency oscillations: from interneurones to pyramidal cells, and back
Mann, E. O., Radcliffe, C. A., & Paulsen, O. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.078758 · Cited by 150
Ephaptic coupling promotes synchronous firing of cerebellar purkinje cells
Han, K.-S., Guo, C., Chen, C. H., Witter, L., Osorno, T., & Regehr, W. G. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.018 · Cited by 144
Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system
Giaume, C., & Theis, M. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.005 · Cited by 142
Blockade of Gap Junctions In Vivo Provides Neuroprotection After Perinatal Global Ischemia
Pina-Benabou, M. H. D., Szostak, V., Kyrozis, A., Rempe, D. A., Uziel, D., Urban-Maldonado, M. M., Benabou, S., Spray, D. C., Federoff, H. J., Stanton, P. K., et al. (2005) · Stroke · doi:10.1161/01.str.0000182239.75969.d8 · Cited by 132
Olfactory Bulb External Tufted Cells Are Synchronized by Multiple Intraglomerular Mechanisms
Hayar, A. M., Shipley, M. T., & Ennis, M. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2374-05.2005 · Cited by 123
Direct Actions of Carbenoxolone on Synaptic Transmission and Neuronal Membrane Properties
Tovar, K. R., Maher, B. J., & Westbrook, G. L. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00060.2009 · Cited by 125
Effects of gap junction blockers on human neocortical synchronization
Gigout, S., Louvel, J., Kawasaki, H., D’Antuono, M., Armand, V., Kurcewicz, I., Olivier, A., Laschet, J. J., Turak, B., Devaux, B. C., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.011 · Cited by 118
Gap-Junctional Coupling and Absolute Sensitivity of Photoreceptors in Macaque Retina
Hornstein, E. P., Verweij, J., Li, P. H., & Schnapf, J. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3416-05.2005 · Cited by 114
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D'Angelo, E. U., Solinas, S. M. G., Mapelli, J., Gandolfi, D., Mapelli, L., & Prestori, F. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00093 · Cited by 117
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Astrocytes play a critical role in transient heterosynaptic depression in the rat hippocampal CA1 region
Andersson, M., Blomstrand, F., & Hanse, E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142737 · Cited by 119
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Pickard, G. E., & Sollars, P. J. (2010) · Science China Life Sciences · doi:10.1007/s11427-010-0024-5 · Cited by 106
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Screening of gap junction antagonists on dye coupling in the rabbit retina
PAN, F., Mills, S. L., & Massey, S. C. (2007) · Visual Neuroscience · doi:10.1017/s0952523807070472 · Cited by 106
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Effects of pH Buffering on Horizontal and Ganglion Cell Light Responses in Primate Retina: Evidence for the Proton Hypothesis of Surround Formation
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Intrinsic oscillatory activity arising within the electrically coupled AII amacrine–ON cone bipolar cell network is driven by voltage‐gated Na + channels
Trenholm, S., Borowska, J., Zhang, J., Hoggarth, A., Johnson, K., Barnes, S., Lewis, T. J., & Awatramani, G. B. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.225060 · Cited by 102
Self-citation
Intrinsically Photosensitive Retinal Ganglion Cells
Pickard, G. E., & Sollars, P. J. (2011) · Springer eBooks · doi:10.1007/112_2011_4 · Cited by 103
Simultaneous Contribution of Two Rod Pathways to AII Amacrine and Cone Bipolar Cell Light Responses
Trexler, E. B., Li, W., & Massey, S. C. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00597.2004 · Cited by 94
Tracer coupling of intrinsically photosensitive retinal ganglion cells to amacrine cells in the mouse retina
Müller, L. P. D. S., Do, M. T. H., Yau, K., He, S., & Baldridge, W. H. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22490 · Cited by 95
Connexin 43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures
Samoilova, M., Wentlandt, K., Adamchik, Y., Velumian, A. A., & Carlen, P. L. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.01.005 · Cited by 86
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Connors, B. W. (2012) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7511-12.2.66 · Cited by 93
Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter
Krämer, R., & Davenport, C. M. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002322 · Cited by 87
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Benfenati, V., Caprini, M., Nicchia, G. P., Rossi, A., Dovizio, M., Cervetto, C., Nobile, M., & Ferroni, S. (2009) · Channels · doi:10.4161/chan.3.5.9568 · Cited by 80
The role of gap junctions in the brain in health and disease
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Vlasits, A. L., Bos, R., Morrie, R. D., Fortuny, C., Flannery, J. G., Feller, M. B., & Rivlin‐Etzion, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.037 · Cited by 62
Astroglial networking contributes to neurometabolic coupling
Escartin, C., & Rouach, N. (2013) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2013.00004 · Cited by 75
I nhibition of astroglial connexin43 hemichannels with TAT ‐ G ap19 exerts anticonvulsant effects in rodents
Walrave, L., Pierre, A., Albertini, G., Aourz, N., Bundel, D. D., Eeckhaut, A. V., Vinken, M., Giaume, C., Leybaert, L., & Smolders, I. J. (2018) · Glia · doi:10.1002/glia.23341 · Cited by 63
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LRRC8A is essential for swelling‐activated chloride current and for regulatory volume decrease in astrocytes
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Behringer, E. J., Socha, M. J., Polo‐Parada, L., & Segal, S. S. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01814.x · Cited by 54
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Ha, N. T., & Dougherty, K. J. (2018) · eLife · doi:10.7554/elife.42519 · Cited by 56
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Expression and function of the neuronal gap junction protein connexin 36 in developing mammalian retina
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Authors: Vessey, J. P., Lalonde, M. R., Mizan, H. A., Welch, N. C., Kelly, M. E. M., & Barnes, S.
Affiliations: Dalhousie University (CA)
ORCID: Barnes, Steven
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 2004-08
Volume: 92
Issue: 2
Pages: 1252-1256
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.00148.2004
OpenAlex: W2010736218
Cited by: 178
References: 24
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 11 · 2015: 6 · 2014: 10 · 2013: 8 · 2012: 16
FWCI: 4.38
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords: carbenoxolone, voltage-gated calcium channels, synaptic transmission, retina, horizontal cells, photoreceptors, Müller cells, hemichannels, calcium channel inhibition, cone photoreceptors
MeSH terms: Ambystoma, Aniline Compounds, Animals, Calcium Channel Blockers, Carbenoxolone, Electrophysiology, Fluorescent Dyes, Larva, Neural Inhibition, Synaptic Transmission, Retina, Xanthenes, Calcium Channels, Retinal Cone Photoreceptor Cells, Patch-Clamp Techniques, Photoreceptor Cells, Vertebrate, In Vitro Techniques

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Carbenoxolone Inhibition of Voltage-Gated Ca Channels and Synaptic Transmission in the Retina

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