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Current Source Density Profiles of Stimulus-Specific Adaptation in Rat Auditory Cortex
Abstract
Neurons in primary auditory cortex (A1) are known to exhibit a phenomenon known as stimulus-specific adaptation (SSA), which means that, when tested with pure tones, they will respond more strongly to a particular frequency if it is presented as a rare, unexpected “oddball” stimulus than when the same stimulus forms part of a series of common, “standard” stimuli. Although SSA has occasionally been observed in midbrain neurons that form part of the paraleminscal auditory pathway, it is thought to be weak, rare, or nonexistent among neurons of the leminscal pathway that provide the main afferent input to A1, so that SSA seen in A1 is likely generated within A1 by local mechanisms. To study the contributions that neural processing within the different cytoarchitectonic layers of A1 may make to SSA, we recorded local field potentials in A1 of the rat in response to standard and oddball tones and subjected these to current source density analysis. Although our results show that SSA can be observed throughout all layers of A1, right from the earliest part of the response, there are nevertheless significant differences between layers, with SSA becoming significantly stronger as stimulus-related activity passes from the main thalamorecipient layers III and IV to layer V.
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“Adaptation enables high sensitivity to small changes in stimulus features over a large range of intensities, and is found across sensory systems5,17,26,105,210–216.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [214]
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Metadata
- Authors
- Szymanski, F. D., Garcia-Lazaro, J. A., & Schnupp, J. W. H.
- Affiliations
- University of Oxford (GB)
- Italian Institute of Technology (IT)
- ORCID
- Schnupp, Jan W. H.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2009-09
- Volume
- 102
- Issue
- 3
- Pages
- 1483-1490
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2082013844
- Cited by
- 140
- References
- 29
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 11 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 7 · 2013: 10 · 2012: 7
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- stimulus-specific adaptation, primary auditory cortex, current source density, oddball paradigm, local field potentials, rat auditory cortex, pure tone responses
- MeSH terms
- Acoustic Stimulation, Adaptation, Physiological, Animals, Auditory Cortex, Auditory Pathways, Auditory Perception, Contingent Negative Variation, Electroencephalography, Evoked Potentials, Auditory, Female, Mesencephalon, Neurons, Psychophysics, Rats, Long-Evans, Rats
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