Functional maps of neocortical local circuitry.

Thomson, Alex M.

doi:10.3389/neuro.01.1.1.002.2007

Cited by 434Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Functional maps of neocortical local circuitry.

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Thomson, Alex M.·2007·Frontiers in Neuroscience

DOI 10.3389/neuro.01.1.1.002.2007PMC PMC2518047

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Abstract

This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required by those wishing to model the circuit. A brief description of the main techniques used to study circuitry is followed by outline descriptions of the major classes of neocortical excitatory and inhibitory neurones and the connections that each layer makes with other cortical and subcortical regions. Maps summarizing the projection patterns of each class of neurone within the local circuit and tables of the properties of these local circuit connections are provided.This review relies primarily on anatomical studies that have identified the classes of neurones and their local and long distance connections and on paired intracellular and whole-cell recordings which have documented the properties of the connections between them. A large number of different types of synaptic connections have been described, but for some there are only a few published examples and for others the details that can only be obtained with paired recordings and dye-filling are lacking. A further complication is provided by the range of species, technical approaches and age groups used in these studies. Wherever possible the range of available data are summarised and compared. To fill some of the more obvious gaps for the less well-documented cases, data obtained with other methods are also summarized.

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The major excitatory projection of layer 4 neurons is to layer 2/3 neurons.
“The major excitatory projection of layer 4 neurons is to layer 2/3 neurons [45].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [45]
These mappings are consistent with anatomical data.
“These mappings are consistent with anatomical data [42],[45].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [45]

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“Due to the development of new experimental techniques, knowledge of the laminar circuitry of the cortex continues to grow (Thomson and Bannister, 2003; Thomson and Lamy, 2007).”
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Authors: Thomson, A. M.
Affiliations: University of London (GB)
Corresponding author: Thomson, Alex M.
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2007-11-01
Volume: 1
Issue: 1
Pages: 19-42
ISSN: 1662-453X (ISSN-L)
1662-4548
DOI: 10.3389/neuro.01.1.1.002.2007
PMC: PMC2518047
OpenAlex: W2052805224
Cited by: 434
References: 168
Citations by year: 2026: 10 · 2025: 21 · 2024: 16 · 2023: 9 · 2022: 16 · 2021: 19 · 2020: 29 · 2019: 13 · 2018: 22 · 2017: 24 · 2016: 19 · 2015: 32 · 2014: 34 · 2013: 35 · 2012: 35
FWCI: 9.69
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Trust
Novartis Pharma
Medical Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: cortical connectivity, excitatory neurons, inhibitory neurons, cortical layers, subcortical projections, synaptic connectivity, whole-cell recording, functional maps

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Functional maps of neocortical local circuitry.

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