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Cited by 1,049Neuroscience and Music PerceptionHearing, Cochlea, Tinnitus, GeneticsNeural dynamics and brain function

Processing of low-probability sounds by cortical neurons

Ulanovsky, Nachum, Las, Liora, Nelken, Israel·2003·Nature Neuroscience
DOI 10.1038/nn1032
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Abstract

The ability to detect rare auditory events can be critical for survival. We report here that neurons in cat primary auditory cortex (A1) responded more strongly to a rarely presented sound than to the same sound when it was common. For the rare stimuli, we used both frequency and amplitude deviants. Moreover, some A1 neurons showed hyperacuity for frequency deviants--a frequency resolution one order of magnitude better than receptive field widths in A1. In contrast, auditory thalamic neurons were insensitive to the probability of frequency deviants. These phenomena resulted from stimulus-specific adaptation in A1, which may be a single-neuron correlate of an extensively studied cortical potential--mismatch negativity--that is evoked by rare sounds. Our results thus indicate that A1 neurons, in addition to processing the acoustic features of sounds, may also be involved in sensory memory and novelty detection.

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Crossref · 10.1038/nn1032

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42 of 42 references verified0 citation errors · 0 not checkable

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  • MMN is thought to represent the difference between intact neural responses to deviant stimuli and attenuated neural responses to standard stimuli.

    “In the adaptation hypothesis, as neuronal responses to standard stimuli decline after repetitive presentation of standard stimuli (11), MMN is thought to represent the difference between intact neural responses to deviant stimuli and attenuated neural responses to standard stimuli.”

    From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [11]

  • In the adaptation hypothesis, neuronal responses to standard stimuli decline after repetitive presentation of standard stimuli.

    “In the adaptation hypothesis, as neuronal responses to standard stimuli decline after repetitive presentation of standard stimuli (11), MMN is thought to represent the difference between intact neural responses to deviant stimuli and attenuated neural responses to standard stimuli.”

    From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [11]

  • Repetitions of stimuli cause a reduced response to the stimuli (adaptation).

    “However, repetitions of stimuli have been found to cause a reduced response to the stimuli (11).”

    From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [11]

  • Adaptation enables high sensitivity to small changes in stimulus features over a large range of intensities and is found across sensory systems.

    “Adaptation enables high sensitivity to small changes in stimulus features over a large range of intensities, and is found across sensory systems5,17,26,105,210–216.”

    From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [215]

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Authors
Ulanovsky, N., Las, L., & Nelken, I.
Affiliations
Hebrew University of Jerusalem (IL)
Corresponding author
Nelken, Israel
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2003-03-24
Volume
6
Issue
4
Pages
391-398
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn1032
OpenAlex
W2166645545
Cited by
1,049
References
42
Citations by year
2026: 41 · 2025: 50 · 2024: 41 · 2023: 74 · 2022: 37 · 2021: 41 · 2020: 63 · 2019: 40 · 2018: 42 · 2017: 45 · 2016: 43 · 2015: 55 · 2014: 52 · 2013: 56 · 2012: 47
FWCI
14.04
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
primary auditory cortex, stimulus probability, frequency resolution, hyperacuity, auditory thalamus, stimulus-specific adaptation, mismatch negativity, novelty detection, sensory memory, cats
MeSH terms
Acoustic Stimulation, Action Potentials, Animals, Attention, Auditory Cortex, Auditory Pathways, Auditory Perception, Cats, Geniculate Bodies, Habituation, Psychophysiologic, Neurons, Pitch Discrimination, Probability

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