Forebrain and rage reactions

Spiegel, E. A.; Miller, H. R.; Oppenheimer, M. J.

doi:10.1152/jn.1940.3.6.538

Cited by 162Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Forebrain and rage reactions

Spiegel, E. A., Miller, H. R., Oppenheimer, M. J.·1940·Journal of Neurophysiology

DOI 10.1152/jn.1940.3.6.538

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The robust and dramatic 'septal rage' phenotype results from certain electrolytic, physical, or chemical lesions of the septum.
“The robust and dramatic ‘septal rage’ phenotype that results from certain electrolytic, physical, or chemical lesions of the septum (Spiegel et al., 1940; Brady and Nauta, 1953; Albert and Richmond, 1976) have led to a prevailing view that the output of the LS serves to dampen fear and anxiety (Sheehan et al., 2004).”
From Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit (2014) · cites this paper as Spiegel et al., 1940
Classical lesions of the septum, including medial and lateral subdivisions, resulted in the septal rage phenotype characterized by exaggerated defensive responses to non-threatening stimuli.
“Classical lesions of the septum, including both its medial and lateral subdivisions, resulted in the dramatic ‘septal rage’ phenotype, characterized by exaggerated defensive responses to non-threatening stimuli (Spiegel et al., 1940; Brady and Nauta, 1953).”
From Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit (2014) · cites this paper as Spiegel et al., 1940

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“…influence The robust and dramatic ‘septal rage’ phenotype that results from certain electrolytic, physical, or chemical lesions of the septum (Spiegel et al., 1940; Brady and Nauta, 1953; Albert and Richmond, 1976) have led to a prevailing view that the output of the LS serves to dampen…”
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Authors: Spiegel, E. A., Miller, H. R., & Oppenheimer, M. J.
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 1940-11-01
Volume: 3
Issue: 6
Pages: 538-548
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.1940.3.6.538
OpenAlex: W2287732608
Cited by: 162
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 3 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI: 2.29
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: forebrain, aggression, brain lesions

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