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Urge to scratch represented in the human cerebral cortex during itch
Abstract
1. We used functional positron emission tomography (PET), measuring regional cerebral blood flow (rCBF) as an index of neuronal activity, to investigate the central processing of itch in 10 healthy volunteers subjected to intracutaneous injections of histamine. 2. The study has unraveled a central representation that depicts a motor intention of the urge to scratch contingent on the perception of unpleasant itch. The coactivation of the anterior cingulate cortex (ACC), supplementary motor area (SMA), premotor area (PM), and inferior parietal lobule (IPL) substantiates that the posterior sector of the ACC (Brodmann 24) is related to the sensorial/affectional aspect of the event. The premotor cortical areas (SMA, PM) and the IPL may participate in the preparation of an intended action.
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“Thus, we suggest that the activity in SMA and pre-SMA in the present study reflects an urge to withdraw the hand, rather than anxiety, because this activity was not correlated with the anxiety ratings.”
From Threatening a rubber hand that you feel is yours elicits a cortical anxiety response. (2007) · cites this paper as [29]
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Items 201–235 of 235
Functional MRI Advances to Reveal the Hidden Networks Behind the Cerebral Processing of Itch
Papoiu, A. D. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802838-4.00028-5 · Cited by 1
The Functional Role of Response Suppression during an Urge to Relieve Pain
Sundby, K. K., Wagner, J., & Aron, A. R. (2019) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01423 · Cited by 1
“…of the pre-SMA and rIFG corresponded to a heightened urge to cough and also see (Lynn, Demanet, Krebs, Van Dessel, & Brass, 2016; He et al., 2014; Lerner et al., 2008; Mazzone, McLennan, McGovern, Egan, & Farrell, 2007; Kuhtz-Buschbeck et al., 2005; Banzett et al., 2000; Hsieh et al., 1994).”
BackgroundNakagawa, K., Inui, K., & Kakigi, R. (2016) · Springer eBooks · doi:10.1007/978-4-431-55729-6_3 · Cited by 1
Secondary Reactive Conditions in Pruritic Skin
Wallengren, J. (2009) · Springer eBooks · doi:10.1007/978-1-84882-322-8_20 · Cited by 1
Positron Emission Tomography of the Human Brain in an Experimental Itch Model
Darsow, U. G., Drzezga, A. E., Frisch, M., et al. (2001) · International Archives of Allergy and Immunology · doi:10.1159/000053757 · Cited by 1
Pruritus: Pathogenese, Klinik und Entwicklungen in der Therapie
Gollnick, H. P. M., & Weißhaar, E. (2001) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-56437-6_1 · Cited by 1
Schmelz, M., & Handwerker, H. O. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50018-7 · Cited by 1
Juckreiz: Neues zur Pathophysiologie und Therapie
Ständer, S., Metze, D., & Luger, T. A. (2003) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-55661-6_47
Clinical Effect of Opioid Antagonists on Clinical Pruritus
Bergasa, N. V. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-197-0_29
Anticonvulsants for the Treatment of Pruritus
Bergasa, N. V., & Deewan, D. (2009) · Springer eBooks · doi:10.1007/978-1-84882-322-8_45
Ikoma, A. (2010) · Springer eBooks · doi:10.1007/978-3-540-78814-0_13
“As for itch sensation, it has been shown by studies using positron emission tomography (PET) that prefrontal cortex, premotor areas, S1 and ACC are activated in response to histamine-induced itch [11– 13] .”
BackgroundCarstens, E. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00147-x
Occupational Therapy : A Glimpse of Its Future
Crabtree, J. L. (2004) · Institutional Repositories DataBase (IRDB) · doi:10.15027/16442
Neurobiology of Itch (Pruritus)
Akiyama, T., Mochizuki, H., & Carstens, E. (2015) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0025792
pleasantnesscerebral representation of scratching-induced
Neurophysioland, J., Kakigi, R., Mochizuki, H., Tanaka, S., Morita, T., & Wasaka, T. (2015)
Mechanisms of intracerebral pain and itch perception in humans using neuroimaging methods
Kakigi, R. (2012) · PAIN RESEARCH · doi:10.11154/pain.27.203
Zentralnervöse Verarbeitung von Juckreiz
Darsow, U. G., Pfab, F., Valet, M., Huss‐Marp, J., Sprenger, T., Athanasiadis, G. I., Baurecht, H., Zimmer, C., Tölle, T. R., Behrendt, H., et al. (2009) · Allergologie · doi:10.5414/alp32469
Functional brain imaging of acute pain in healthy humans
Lenz, F. A., Casey, K. L., Jones, E. G., & Willis, W. D. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770579.006
Central Representation of Itch
Mochizuki, H., & Yosipovitch, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-33142-3_3
Role of the Anterior Cingulate Cortex in Fear Learning and Sensation Related Behaviors
Descalzi, G. (2014) · TSpace (University of Toronto)
Okhovat, J., & Balin, S. J. (2015) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.1097/01.ewx.0000462665.35251.a1
Inhibitory Actions of Gastrin-releasing Peptide in Mouse Anterior Cingulate Cortex
Cao, X. (2012) · TSpace (University of Toronto)
Jones, O. H. (2016) · Repository@Hull (Worktribe) (University of Hull)
ITCH AND BRAIN FUNCTION IN ATOPIC DERMATITIS.
Ishiuji, Y. (2017) · PubMed · doi:10.15036/arerugi.66.777
Le prurit, une cause de souffrance mal prise en compte mais un thème de recherche en plein essor
Misery, L. (2015) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)30905-7
“Après d’importants travaux initiaux [11], des études en neuro-imagerie fonctionnelle (tomographie par émission de positons [TEP] ou l’imagerie par résonance magnétique fonctionnelle [IRMf]) ont été réalisées chez l’homme pour étudier les régions corticales et sous-corticales impliquées dans le prurit [12].”
Schmelz, M., & Handwerker, H. O. (2007) · Elsevier eBooks · doi:10.1016/b978-84-8174-949-6.50013-7
(1997) · Presses Universitaires de France eBooks · doi:10.3917/puf.dehae.1997.01.0255
Zentralnervöse Verarbeitung von Juckreiz
Darsow, U. G., Pfab, F., Valet, M., Tölle, T. R., Behrendt, H., & Ring, J. (2009) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-540-77148-7_50
Gil, M. W., Jr. (2004) · Itch · doi:10.1201/b14233-8
GREAVES, M. (2004) · doi:10.1002/9780470750520.ch16
Eken, A., Erdoğan, S. B., Yükselen, G., et al. (2023) · medRxiv · doi:10.1101/2023.11.15.23298553
10.1016/b978-0-7020-6275-9.00005-2
(2000) · Time to knit · doi:10.1016/b978-0-7020-6275-9.00005-2
Neural networks of itch: Evidence from brain imaging
Mochizuki, H., Kinnunen, K., & Yosipovitch, G. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34172-4.00025-2
Central mechanisms of chronic pruritus : functional and structural brain imaging
Najafi, P. (2020) · theses.fr (ABES) · doi:10.70675/2d26d334z911bz49daza026z324ddb027a40
Supraspinal Circuit Mechanisms Underlying Itch Processing
Luo, Y., Tang, H.-D., Liao, P., & Jiang, R. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71022
“Sensory cortices encode the sensory features of itch, motor-related regions mediate the urge to scratch, and limbic and midbrain structures contribute to the aversive and rewarding dimensions of itch [8–22].”
Metadata
- Authors
- Hsieh, J. C., Hagermark, O., Stahle-Backdahl, M., Ericson, K., Eriksson, L., Stone-Elander, S., & Ingvar, M.
- Affiliations
- Karolinska Institutet (SE)
- Department of Clinical Neuroscience, Karolinska Institute/Hospital,Stockholm, Sweden.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1994-12-01
- Volume
- 72
- Issue
- 6
- Pages
- 3004-3008
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1902361870
- Cited by
- 237
- References
- 0
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 9
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- pruritus, anterior cingulate cortex, supplementary motor area, premotor cortex, inferior parietal lobule, regional cerebral blood flow, histamine, action preparation, motor intention
- MeSH terms
- Adult, Cerebral Cortex, Cerebrovascular Circulation, Histamine, Humans, Image Processing, Computer-Assisted, Middle Aged, Pruritus, Tomography, Emission-Computed
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