Why Calcium-Stimulated Adenylyl Cyclases?
Abstract
The Ca 2+/calmodulin-stimulated adenylyl cyclases, AC1 and AC8, play a critical role in several forms of neuroplasticity, including long-lasting long-term potentiation (L-LTP) and long-term memory (LTM). By coupling neuronal activity and Ca 2+increases to the production of cAMP, AC1 and AC8 activate cAMP-dependent signal transduction and transcriptional pathways critical for L-LTP and LTM.
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Intracellular Ca2+ release from increased phosphatidylinositol signalling can activate Ca2+-sensitive adenyl cyclases to increase cAMP signalling.
“Conversely, intracellular Ca2+ release from increased phosphatidylinositol signalling can activate Ca2+-sensitive adenyl cyclases to increase cAMP signalling98 (FIG. 3).”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [98]
Cites
Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation
Villacres, E. C., Wong, S. T., Chavkin, C., & Storm, D. R. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03186.1998 · Cited by 187 · see citing works
Self-citationType I Calmodulin‐Sensitive Adenylyl Cyclase Is Neural Specific
Xia, Z., Choi, E., Wang, F., Blazynski, C., & Storm, D. R. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05852.x · Cited by 178 · see citing works
Self-citationSynergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo.
Wayman, G. A., Impey, S., Wu, Z., Kindsvogel, W., Prichard, L., & Storm, D. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47263-8 · Cited by 166 · see citing works
Self-citationLoss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex
Abdel-Majid, R. M., Leong, W. L., Schalkwyk, L. C., Smallman, D. S., Wong, S. T., Storm, D. R., Fine, A., Dobson, M. J., Guernsey, D. L., & Neumann, P. E. (1998) · Nature Genetics · doi:10.1038/980 · Cited by 163 · see citing works
Self-citationImpaired Cerebellar Long-Term Potentiation in Type I Adenylyl Cyclase Mutant Mice
Storm, D. R., Hansel, C., Hacker, B., Parent, A., & Linden, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80500-0 · Cited by 159 · see citing works
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Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
A critical time window for dopamine actions on the structural plasticity of dendritic spines
Yagishita, S., Hayashi-Takagi, A., Ellis-Davies, G. C. R., Urakubo, H., Ishii, S., & Kasai, H. (2014) · Science · doi:10.1126/science.1255514 · Cited by 614 · see citing works
Linking neural activity and molecular oscillations in the SCN
Colwell, C. S. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3086 · Cited by 474 · see citing works
Integration of biochemical signalling in spines
Kennedy, M. B., Beale, H. C., Carlisle, H. J., & Washburn, L. R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1685 · Cited by 286 · see citing works
Dessauer, C. W., Watts, V. J., Ostrom, R. S., Conti, M., Dove, S., & Seifert, R. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013078 · Cited by 201 · see citing works
cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Carlyle, B. C., Nairn, A. C., Wang, M., Yang, Y., Jin, L. E., Simen, A. A., Ramos, B. P., Bordner, K. A., Craft, G. E., Davies, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322360111 · Cited by 139 · see citing works
Brust, T. F., Alongkronrusmee, D., Soto-Velasquez, M., Baldwin, T. A., Ye, Z., Dai, M., Dessauer, C. W., van Rijn, R. M., & Watts, V. J. (2017) · Science Signaling · doi:10.1126/scisignal.aah5381 · Cited by 64 · see citing works
- Authors
- Ferguson, G. D., & Storm, D. R.
- Affiliations
- University of Washington (US)
- ORCID
- Storm, Daniel R.
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2004-10
- Volume
- 19
- Issue
- 5
- Pages
- 271-276
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2115678732
- Cited by
- 138
- References
- 5
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 8
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- AC1, long-term potentiation, long-term memory, neuroplasticity, cAMP signaling, cAMP-dependent transcription, neuronal activity
- MeSH terms
- Adenylyl Cyclases, Animals, Calcium, Calmodulin, Neurons, Signal Transduction
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