A critical time window for dopamine actions on the structural plasticity of dendritic spines
Open accessAbstract
Animal behavior follows rewards: Animal behavior is learned and reinforced by rewards. On a molecular level, the reward comes in the form of the neurotransmitter, dopamine, which modulates synapses. The exact timing and mechanism of this process remain unknown. Using optical stimulation, Yagishita et al. found that dopaminergic modulation involved dendritic spine enlargement only during an extremely narrow time window. Known as reinforcement plasticity, this cellular basis for learning could provide insight into psychiatric disorders involving dopaminergic regulation, such as depression, drug addiction, and schizophrenia. Science , this issue p. 1616
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Dopamine receptor activation is not required for this potentiation but may modulate it under physiological conditions.
“Dopamine receptor activation is not required for this potentiation but may be modulatory under physiological conditions [229].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [229]
PPP1R1B affects synaptic plasticity and reward-based learning in the striatum and contributes to behavioral effects of nicotine in mice.
“a signal transduction gene that affects synaptic plasticity and reward-based learning in the striatum29,30 and contributes to the behavioral effects of nicotine in mice31.”
From Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use (2019) · cites this paper as [30]
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- Authors
- Yagishita, S., Hayashi-Takagi, A., Ellis-Davies, G. C. R., Urakubo, H., Ishii, S., & Kasai, H.
- Affiliations
- Japan Science and Technology Agency (JP)
- Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
- Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.
- Kyoto University (JP)
- Corresponding author
- Kasai, Haruo
- Venue
- Science
- Published
- 2014-09-26
- Volume
- 345
- Issue
- 6204
- Pages
- 1616-1620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4225776
- OpenAlex
- W2041848110
- Cited by
- 614
- References
- 38
- Citations by year
- 2026: 39 · 2025: 68 · 2024: 57 · 2023: 51 · 2022: 56 · 2021: 69 · 2020: 59 · 2019: 50 · 2018: 54 · 2017: 30 · 2016: 47 · 2015: 29 · 2014: 5
- FWCI
- 16.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science (26540154)
- National Institute on Drug Abuse (R21DA035612, DA035612)
- National Institute of General Medical Sciences (GM 53395, R01GM053395)
- National Institute of Neurological Disorders and Stroke (R01NS069720, NS069720)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopamine, dendritic spines, structural plasticity, reward timing, synaptic plasticity, striatum, medium spiny neurons, cAMP signaling, protein kinase A, phosphodiesterase, glutamatergic input, reinforcement learning, time windows
- MeSH terms
- Cyclic AMP, Animals, Dopamine, Learning, Neuronal Plasticity, Phosphoric Diester Hydrolases, Reward, Time Factors, Cyclic AMP-Dependent Protein Kinases, Glutamic Acid, Dendritic Spines, Dopamine Plasma Membrane Transport Proteins, Mice, Electrical Synapses
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