The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Macrophages in Kidney Injury, Inflammation, and Fibrosis
Abstract
Macrophages are found in normal kidney and in increased numbers in diseased kidney, where they act as key players in renal injury, inflammation, and fibrosis. Macrophages are highly heterogeneous cells and exhibit distinct phenotypic and functional characteristics in response to various stimuli in the local microenvironment in different types of kidney disease. In kidney tissue necrosis and/or infection, damage- and/or pathogen-associated molecular patterns induce pro-inflammatory macrophages, which contribute to further tissue injury, inflammation, and subsequent fibrosis. Apoptotic cells and anti-inflammatory factors in post-inflammatory tissues induced anti-inflammatory macrophages, which can mediate kidney repair and regeneration. This review summarizes the role of macrophages with different phenotypes in kidney injury, inflammation, and fibrosis in various acute and chronic kidney diseases. Understanding alterations of kidney microenvironment and the factors that control the phenotype and functions of macrophages may offer an avenue for the development of new cellular and cytokine/growth factor-based therapies as alternative treatment options for patients with kidney disease.
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Citations
Cites
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Cited by
Targeting the progression of chronic kidney disease
Ruiz-Ortega, M., Rayego-Mateos, S., Lamas, S., Ortiz, A., & Rodrigues-Diez, R. R. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0248-y · Cited by 979
Inflammation and Progression of CKD: The CRIC Study
Amdur, R. L., Feldman, H. I., Gupta, J., Yang, W., Kanetsky, P., Shlipak, M., Rahman, M., Lash, J. P., Townsend, R. R., Ojo, A., et al. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.13121215 · Cited by 452
Huang, H., Liu, H., Tang, J., Xu, W., Gan, H., Fan, Q., & Zhang, W. (2020) · IUBMB Life · doi:10.1002/iub.2393 · Cited by 72
Long, H., Lichtnekert, J., Andrassy, J., Schraml, B. U., Romagnani, P., & Anders, H.-J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194988 · Cited by 46
Dusabimana, T., Je, J., Yun, S. P., Kim, H. J., Kim, H., & Park, S. W. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05975-x · Cited by 45
Metadata
- Authors
- Cao, Q., Harris, D. C. H., & Wang, Y.
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2015-05
- Volume
- 30
- Issue
- 3
- Pages
- 183-194
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2037466124
- Cited by
- 341
- References
- 13
- FWCI
- 16.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
