The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
A compendium of gene expression in normal human tissues
Abstract
This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of ∼7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org ) for future studies of pathophysiology.
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Cited by
Yanai, I., Benjamin, H., Shmoish, M., Chalifa-Caspi, V., Shklar, M., Ophir, R., Bar-Even, A., Horn-Saban, S., Safran, M., Domany, E., et al. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti042 · Cited by 1,300
Monaco, G., Lee, B., Xu, W., Mustafah, S., Hwang, Y. Y., Carré, C., Burdin, N., Visan, L., Ceccarelli, M., Poidinger, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.041 · Cited by 958
Human housekeeping genes are compact
Eisenberg, E., & Levanon, E. Y. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00140-9 · Cited by 698
Identification and validation of reference genes for quantitative RT-PCR normalization in wheat
Paolacci, A. R., Tanzarella, O. A., Porceddu, E., & Ciaffi, M. (2009) · BMC Molecular Biology · doi:10.1186/1471-2199-10-11 · Cited by 687
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation
Tarpey, P. S., Smith, R., Pleasance, E., Whibley, A., Edkins, S., Hardy, C., O'Meara, S., Latimer, C., Dicks, E., Menzies, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.367 · Cited by 603
Metadata
- Authors
- HSIAO, L.-L., DANGOND, F., YOSHIDA, T., HONG, R., JENSEN, R. V., MISRA, J., DILLON, W., LEE, K. F., CLARK, K. E., HAVERTY, P., WENG, Z., MUTTER, G. L., FROSCH, M. P., MacDONALD, M. E., MILFORD, E. L., CRUM, C. P., BUENO, R., PRATT, R. E., MAHADEVAPPA, M., WARRINGTON, J. A., STEPHANOPOULOS, G., STEPHANOPOULOS, G., & GULLANS, S. R.
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2001-12-21
- Volume
- 7
- Issue
- 2
- Pages
- 97-104
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2120920194
- Cited by
- 503
- References
- 38
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- HSIAO, L.-L., DANGOND, F., YOSHIDA, T., HONG, R., JENSEN, R. V., MISRA, J., DILLON, W., LEE, K. F., CLARK, K. E., HAVERTY, P., WENG, Z., MUTTER, G. L., FROSCH, M. P., MacDONALD, M. E., MILFORD, E. L., CRUM, C. P., BUENO, R., PRATT, R. E., MAHADEVAPPA, M., . . . GULLANS, S. R. (2001). A compendium of gene expression in normal human tissues. Physiological Genomics. https://doi.org/10.1152/physiolgenomics.00040.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
