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Comparison of human adult and fetal expression and identification of 535 housekeeping/maintenance genes
Abstract
Warrington, Janet A., Archana Nair, Mamatha Mahadevappa, and Maya Tsyganskaya. Comparison of human adult and fetal expression and identification of 535 housekeeping/maintenance genes. Physiol Genomics 2: 143–147, 2000.—Gene expression levels of about 7,000 genes were measured in 11 different human adult and fetal tissues using high-density oligonucleotide arrays to identify genes involved in cellular maintenance. The tissues share a set of 535 transcripts that are turned on early in fetal development and stay on throughout adulthood. Because our goal was to identify genes that are involved in maintaining cellular function in normal individuals, we minimized the effect of individual variation by screening mRNA pooled from many individuals. This information is useful for establishing average expression levels in normal individuals. Additionally, we identified transcripts uniquely expressed in each of the 11 tissues.
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Cited by
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Andersen, C. L., Jensen, J. L., & Ørntoft, T. F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0496 · Cited by 7,127
Yanai, I., Benjamin, H., Shmoish, M., Chalifa-Caspi, V., Shklar, M., Ophir, R., Bar-Even, A., Horn-Saban, S., Safran, M., Domany, E., et al. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti042 · Cited by 1,300
Large-scale analysis of the human and mouse transcriptomes
Su, A. I., Cooke, M. P., Ching, K. A., Hakak, Y., Walker, J. R., Wiltshire, T., Orth, A. P., Vega, R. G., Sapinoso, L. M., Moqrich, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012025199 · Cited by 1,466
Peltier, H. J., & Latham, G. J. (2008) · RNA · doi:10.1261/rna.939908 · Cited by 820
Metadata
- Authors
- WARRINGTON, J. A., NAIR, A., MAHADEVAPPA, M., & TSYGANSKAYA, M.
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2000-04-27
- Volume
- 2
- Issue
- 3
- Pages
- 143-147
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2160619422
- Cited by
- 541
- References
- 0
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- WARRINGTON, J. A., NAIR, A., MAHADEVAPPA, M., & TSYGANSKAYA, M. (2000). Comparison of human adult and fetal expression and identification of 535 housekeeping/maintenance genes. Physiological Genomics. https://doi.org/10.1152/physiolgenomics.2000.2.3.143
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