The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters
Open accessAbstract
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO 3 exchangers (AE1–3), five Na+-coupled HCO 3−transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2. Each plays a specialized role in maintaining intracellular pH and, by contributing to the movement of HCO 3−across epithelia, in maintaining whole-body pH and otherwise contributing to epithelial transport. Disruptions involving NCBT genes are linked to blindness, deafness, proximal renal tubular acidosis, mental retardation, and epilepsy. We also review AE1–3, AE4, and BTR1, addressing their relevance to the study of NCBTs. This review draws together recent advances in our understanding of the phylogenetic origins and physiological relevance of NCBTs and their progenitors. Underlying these advances is progress in such diverse disciplines as physiology, molecular biology, genetics, immunocytochemistry, proteomics, and structural biology. This review highlights the key similarities and differences between individual NCBTs and the genes that encode them and also clarifies the sometimes confusing NCBT nomenclature.
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Primary production of the biosphere: Integrating terrestrial and oceanic components
Field, C. B., Behrenfeld, M. J., Randerson, J. T., & Falkowski, P. (1998) · Science · doi:10.1126/science.281.5374.237 · Cited by 6,371
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Strong association of de novo copy number mutations with autism
Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., et al. (2007) · Science · doi:10.1126/science.1138659 · Cited by 2,795
Cellular mechanisms of muscle fatigue
Fitts, R. H. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.49 · Cited by 1,537
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
Wei, C.-L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.043 · Cited by 1,141
O'Neill, M. A., Ishii, T., Albersheim, P., & Darvill, A. G. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141750 · Cited by 975
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Regulation of tumor pH and the role of carbonic anhydrase 9
Swietach, P., Vaughan-Jones, R. D., & Harris, A. L. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9064-0 · Cited by 539
Michelsen, K., Yuan, H., & Schwappach, B. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400480 · Cited by 235
Stoichiometry and Ion Dependencies of the Intracellular-pH-Regulating Mechanism in Squid Giant Axons
Boron, W. F., & Russell, J. M. (1983) · The Journal of general physiology · doi:10.1085/jgp.81.3.373 · Cited by 169
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Metadata
- Authors
- Parker, M. D., & Boron, W. F.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2013-04
- Volume
- 93
- Issue
- 2
- Pages
- 803-959
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2158074474
- Cited by
- 289
- References
- 11
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
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