The DOI matches its Crossref record; 291 of the 292 references it cites were found in a registry or an index.
Thyroid Hormone Regulation of Metabolism
Open accessAbstract
Thyroid hormone (TH) is required for normal development as well as regulating metabolism in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially expressed in tissues and have distinct roles in TH signaling. Local activation of thyroxine (T 4 ), to the active form, triiodothyronine (T 3 ), by 5′-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism. D2 is expressed in the hypothalamus, white fat, brown adipose tissue (BAT), and skeletal muscle and is required for adaptive thermogenesis. The thyroid gland is regulated by thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH). In addition to TRH/TSH regulation by TH feedback, there is central modulation by nutritional signals, such as leptin, as well as peptides regulating appetite. The nutrient status of the cell provides feedback on TH signaling pathways through epigentic modification of histones. Integration of TH signaling with the adrenergic nervous system occurs peripherally, in liver, white fat, and BAT, but also centrally, in the hypothalamus. TR regulates cholesterol and carbohydrate metabolism through direct actions on gene expression as well as cross-talk with other nuclear receptors, including peroxisome proliferator-activated receptor (PPAR), liver X receptor (LXR), and bile acid signaling pathways. TH modulates hepatic insulin sensitivity, especially important for the suppression of hepatic gluconeogenesis. The role of TH in regulating metabolic pathways has led to several new therapeutic targets for metabolic disorders. Understanding the mechanisms and interactions of the various TH signaling pathways in metabolism will improve our likelihood of identifying effective and selective targets.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“LT4 suppression therapy may also affect metabolic function, since thyroid hormone plays a critical role in determining energy expenditure, body mass, and body composition (2).”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Lin, H., Tang, H.-Y., Shih, A., Keating, T., Cao, G., Davis, P. J., & Davis, F. B. (2006) · Steroids · doi:10.1016/j.steroids.2006.11.014 · Cited by 132
RetractedBrown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
(1992) · Applied Ergonomics · doi:10.1016/0003-6870(92)90318-p · Cited by 5,774
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
Semenza, G. L. (2010) · Oncogene · doi:10.1038/onc.2009.441 · Cited by 1,712
Research works printed but not linked: 15
- Al-Adsani H, 1997, J Clin Endocrinol Metab, 82, 1118
- Celani MF, 1994, Diabetes Res, 27, 15
- Dasgupta S, Annu Rev Med
- Edelman IS, 1974, Recent Prog Horm Res, 30, 235
- Gullberg H, 2000, Mol Endocrinol, 14, 1739
- Ishay A, 2009, Med Sci Monit, 15, CR151
- Ismail-Beigi F, 1992, Semin Nephrol, 12, 44
- Larsen PR, 2012, Eur Thyroid J, 1, 232
- Lonn L, 1998, J Clin Endocrinol Metab, 83, 4269
- Sherman SI, 1997, J Clin Endocrinol Metab, 82, 2153
- Shoemaker TJ, 2012, Endocr Pract, 1
- Simonides WS, 2008, J Clin Invest, 118, 975
- Sundler F, 1989, Acta Histochem, 191
- Vondra K, 2005, Minerva Endocrinol, 30, 217
- Webb P, 2010, Curr Opin Invest Drugs, 11, 1135
Cited by
Sorted by citations
Items 501–600 of 998
Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review
Pang, K.-L., Lumintang, J. N., & Chin, K. (2021) · Nutrients · doi:10.3390/nu13020529 · Cited by 26
Miao, Y., Mei, Q., Fu, C., Liao, M., Liu, Y., Xu, X., Li, X., Zhao, S., & Xiang, T. (2021) · BMC Genomics · doi:10.1186/s12864-021-07570-w · Cited by 27
Self-citationSong, J., Lu, Y., Cheng, X., Shi, C., Lou, Q., Jin, X., He, J., Zhai, G., & Yin, Z. (2021) · Cells · doi:10.3390/cells10081984 · Cited by 24
Thyroid Glands: Physiology and Structure
Al-Suhaimi, E. A., & Khan, F. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-9016-7_5 · Cited by 24
Khalid, W., Maqbool, Z., Arshad, M. S., Kousar, S., Akram, R., Siddeeg, A., Ali, A., Qin, H., Aziz, A., Saeed, A., et al. (2022) · International Journal of Food Properties · doi:10.1080/10942912.2022.2070643 · Cited by 24
RetractedRaets, L., Minschart, C., den Bruel, A. V., den Bogaert, E. V., Crombrugge, P. V., Moyson, C., Verhaeghe, J., Vandeginste, S., Verlaenen, H., Vercammen, C., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175016 · Cited by 27
Sotelo-Rivera, I., Jaimes-Hoy, L., Cote-Vélez, A., Espinoza‐Ayala, C., Charli, J., & Joseph‐Bravo, P. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12224 · Cited by 24
Friedrich, N., Pietzner, M., Cannet, C., Thuesen, B. H., Hansen, T., Wallaschofski, H., Grarup, N., Skaaby, T., Budde, K., Pedersen, O., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0173078 · Cited by 23
The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): An Overview
Silvestrini, A., Mordente, A., Martino, G., Bruno, C., Vergani, E., Meucci, E., & Mancini, A. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180201111159 · Cited by 25
Lee, J., Ha, J., Jo, K., Lim, D., Lee, J., Chang, S., Kang, M.-I., & Kim, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060758 · Cited by 24
Thyroid Function and Nutrient Status in the Athlete
Larson‐Meyer, D. E., & Gostas, D. E. (2020) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000689 · Cited by 28
Chronic stress and adipose tissue in the anorexic state: endocrine and epigenetic mechanisms
Xiao, Y., Liu, D., Cline, M. A., & Gilbert, E. R. (2020) · Adipocyte · doi:10.1080/21623945.2020.1803643 · Cited by 25
Gao, B., Yang, C., Liu, J., & Zhou, X. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009293 · Cited by 23
Bennett, K. A., Robinson, K. J., Armstrong, H. C., Moss, S. E. W., Scholl, G., Tranganida, A., Eppe, G., Thomé, J., Debier, C., & Hall, A. J. (2021) · Environment International · doi:10.1016/j.envint.2021.106506 · Cited by 23
Detrimental or beneficial? Untangling the literature on developmental stress studies in birds
Wada, H., & Coutts, V. M. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.227363 · Cited by 23
Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy
Mehdipour, M., Park, S., & Huang, G. N. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.02.002 · Cited by 24
Insights into Transcriptional Regulation of Hepatic Glucose Production
Anyamaneeratch, K., Rojvirat, P., Sukjoi, W., & Jitrapakdee, S. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.05.004 · Cited by 25
Miyaso, H., Nakamura, N., Naito, M., Hirai, S., Matsuno, Y., Itoh, M., & Mori, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114487 · Cited by 23
Interrelationship between 3,5,3´-triiodothyronine and the circadian clock in the rodent heart
Garcia, R. A. P., Prévide, R. M., Nunes, M. T., & Young, M. E. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1229673 · Cited by 23
An, J. H., Song, K., Kim, D., & Kim, S. K. (2016) · Journal of International Medical Research · doi:10.1177/0300060516664242 · Cited by 23
The Radioprotective Effects of Curcumin and Trehalose Against Genetic Damage Caused By I-131
Mohseni, M., Jafarpour, S. M., Safaei, M., Salimian, M., Aliasgharzadeh, A., & Farhood, B. (2018) · Indian Journal of Nuclear Medicine · doi:10.4103/ijnm.ijnm_158_17 · Cited by 23
Hwang, J. H., Jung, H. W., Kang, S. Y., Kang, A. N., Ma, J., Meng, X., Hwang, M. S., & Park, Y. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6190 · Cited by 23
Statin Use and Gastrointestinal Hemorrhage: A Large Retrospective Cohort Study
Martinez, A. I., Freeman, P. R., & Moga, D. C. (2018) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-018-0301-4 · Cited by 23
Çakır, I., Martinez, M. D., Pan, P. L., Welch, E. B., Patel, S. H., & Ghamari‐Langroudi, M. (2019) · Endocrinology · doi:10.1210/en.2019-00062 · Cited by 22
Costa, L. E. S., Clementino-Neto, J., Mendes, C. B., Franzon, N. H., Costa, E. D. O., Moura‐Neto, V., & Ximenes-da-Silva, A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00317 · Cited by 23
A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity
Vila, I. K., Park, M. K., Setijono, S. R., Yao, Y., Kim, H., Badin, P.-M., Choi, S., Narkar, V. A., Choi, S., Chung, J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.128269 · Cited by 23
Developmental programming: Sex‐specific programming of growth upon prenatal bisphenol A exposure
Vyas, A. K., Veiga‐Lopez, A., Ye, W., Salloum, B. A., Abbott, D. H., Yang, S., Liao, C., Kannan, K., & Padmanabhan, V. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3836 · Cited by 22
miR-22-3p is involved in gluconeogenic pathway modulated by 3,5-diiodo-L-thyronine (T2)
Senese, R., Cioffi, F., Petito, G., de Lange, P., Russo, A., Goglia, F., Lanni, A., & Potenza, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-53019-2 · Cited by 23
González-Ramos, S., Paz-García, M., Fernández-García, V., Portune, K. J., Acosta-Medina, E. F., Sanz, Y., Castrillo, A., Martín‐Sanz, P., Obregón, M.-J., & Boscá, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-69295-2 · Cited by 24
Thyroid Function in Adults with Prader–Willi Syndrome; a Cohort Study and Literature Review
Pellikaan, K., Snijders, F., Rosenberg, A. G. W., Davidse, K., van den Berg, S. A. A., Visser, W. E., van der Lely, A. J., & de Graaff, L. C. G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173804 · Cited by 24
Fontana, A., Vieira, J. G., Vianna, J. M., Bichowska, M., Krzysztofik, M., Wilk, M., & Reis, V. M. (2023) · PLOS ONE · doi:10.1371/journal.pone.0288730 · Cited by 22
Lu, X., Arbab, A. A. I., Zhang, Z., Fan, Y., Han, Z., Gao, Q., Sun, Y., & Yang, Z. (2020) · Animals · doi:10.3390/ani10081271 · Cited by 22
Survey analysis of exercise participation and skeletal muscle symptoms in women with hypothyroidism
Guerin, G. D., Gordon, R. A., Zumbro, E. L., Amuta, A. O., & Duplanty, A. A. (2020) · Women & Health · doi:10.1080/03630242.2020.1831682 · Cited by 23
Targeting Glucose Metabolism: A Novel Therapeutic Approach for Parkinson’s Disease
Tanvir, A., Jo, J., & Park, S. M. (2024) · Cells · doi:10.3390/cells13221876 · Cited by 52
Schanze, N., Jacobi, S. F., Rijntjes, E., Mergler, S., del Olmo, M., Hoefig, C. S., Khajavi, N., Lehmphul, I., Biebermann, H., Mittag, J., et al. (2016) · Thyroid · doi:10.1089/thy.2016.0182 · Cited by 22
Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor
Affortit, C., Casas, F., Ladrech, S., Ceccato, J., Bourien, J., Coyat, C., Puel, J., Lenoir, M., & Wang, J. (2021) · BMC Biology · doi:10.1186/s12915-021-00953-1 · Cited by 22
Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and Compensatory Brain Changes
Niedowicz, D. M., Wang, W., PRICE, D. A., & Nelson, P. T. (2021) · Journal of Thyroid Research · doi:10.1155/2021/9960188 · Cited by 23
Hu, Y., Ding, G., Lv, C., Zhang, Q., Zhang, Y., Yuan, T., Ao, J., Gao, Y., Xia, Y., Yu, X., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113610 · Cited by 22
Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation
de Assis, L. V. M., Harder, L., Lacerda, J. T., Parsons, R., Kaehler, M., Cascorbi, I., Nagel, I., Rawashdeh, O., Mittag, J., & Oster, H. (2022) · eLife · doi:10.7554/elife.79405 · Cited by 21
Bruijn, N., van Lohuizen, R., Boron, M., Fitzek, M. P., Gabriele, F., Giuliani, G., Melgarejo, L., Řehulka, P., Sebastianelli, G., Triller, P., et al. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01724-3 · Cited by 23
Videla, L. A., Fernández, V., Vargas, R., Cornejo, P., Tapia, G., Varela, N., Valenzuela, R., Arenas, A., Fernández, J., Hernández‐Rodas, M. C., et al. (2016) · BioFactors · doi:10.1002/biof.1300 · Cited by 22
Rojas, J. M., Bolze, F., Thorup, I., Nowak, J., Dalsgaard, C. M., Skydsgaard, M., Berthelsen, L. O., Keane, K. A., Søeborg, H., Sjögren, I., et al. (2018) · Toxicologic Pathology · doi:10.1177/0192623318803557 · Cited by 22
Nabi, G., Hao, Y., McLaughlin, R. W., & Wang, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01665 · Cited by 22
Domenech-Coca, C., Mariné-Casadó, R., Caimari, A., Arola, L., Bas-Prior, J. M. D., Bladé, C., & Rodriguez-Naranjo, M. I. (2019) · Journal of Chromatography B · doi:10.1016/j.jchromb.2019.01.002 · Cited by 22
Elevated serum neuregulin 4 levels in patients with hyperthyroidism
Li, M., Chen, Y., Jiang, J., Lü, Y., Song, Z., Zhang, S., Sun, C., Ying, H., Fan, X., Song, Y., et al. (2019) · Endocrine Connections · doi:10.1530/ec-19-0175 · Cited by 22
Functional and Symptomatic Individuality in the Response to Levothyroxine Treatment
Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J. W. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00664 · Cited by 22
Elnesr, S. S., Abdel‐Razik, A. H., & Elwan, H. A. M. (2021) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13543 · Cited by 22
Regulation of Thyroid Function, Synthesis, and Function of Thyroid Hormones
Visser, T. J. (2018) · Endocrinology · doi:10.1007/978-3-319-45013-1_1 · Cited by 22
Metabolic Syndrome in Thyroid Disease
Iwen, K. A., Oelkrug, R., Kalscheuer, H., & Brabant, G. E. (2018) · Frontiers of hormone research · doi:10.1159/000485996 · Cited by 21
Gao, H. Y., Li, P., Liu, L., Yang, K., Xiao, B., Zhou, G., Tian, Z., Luo, C., Xia, T., Dong, L., et al. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.05.277 · Cited by 21
Abdollahpour, H., Falahatkar, B., & Kraak, G. V. D. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737065 · Cited by 21
Abdel-Hamid, M., Yang, P., Mostafa, I., Osman, A., Romeih, E., Yang, Y., Huang, Z., Awad, A. A., & Li, L. (2022) · Molecules · doi:10.3390/molecules27051575 · Cited by 21
The Role of Thyroid Hormones on Skeletal Muscle Thermogenesis
Sawicka‐Gutaj, N., Erampamoorthy, A., Zybek‐Kocik, A., Kyriacou, A., Zgorzalewicz-Stachowiak, M., Czarnywojtek, A., & Ruchała, M. (2022) · Metabolites · doi:10.3390/metabo12040336 · Cited by 21
Hetman, M., & Barg, E. (2022) · Biomedicines · doi:10.3390/biomedicines10123219 · Cited by 21
Tee, S. A., Tsatlidis, V., & Razvi, S. (2023) · Clinical Endocrinology · doi:10.1111/cen.14901 · Cited by 21
Dasa, M. S., Friborg, O., Kristoffersen, M., Pettersen, G., Sagen, J. V., Sundgot-Borgen, J. K., & Rosenvinge, J. H. (2023) · Sports Medicine - Open · doi:10.1186/s40798-023-00605-4 · Cited by 21
Amorim, R., Soares, P., Chavarria, D., Benfeito, S., Cagide, F., Teixeira, J., Oliveira, P. J., & Borges, F. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116723 · Cited by 21
A link between hypothyroidism, obesity and male reproduction
Aiceles, V., & Ramos, C. D. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0054 · Cited by 21
Leptin regulation of core body temperature involves mechanisms independent of the thyroid axis
Deem, J. D., Muta, K., Ogimoto, K., Nelson, J. T., VELASCO, K. R., Kaiyala, K. J., & Morton, G. J. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00462.2017 · Cited by 20
Changes in Lipid Indices in HIV+ Cases on HAART
Ji, S., Xu, Y., Han, D., Peng, X., Lu, X., Brockmeyer, N. H., & Wu, N. (2019) · BioMed Research International · doi:10.1155/2019/2870647 · Cited by 21
CREG1 stimulates brown adipocyte formation and ameliorates diet‐induced obesity in mice
Hashimoto, M., Kusudo, T., Takeuchi, T., Kataoka, N., Mukai, T., & Yamashita, H. (2019) · The FASEB Journal · doi:10.1096/fj.201802147rr · Cited by 21
Effects of long-term heat exposure on cholesterol metabolism and immune responses in growing pigs
Wen, X., Wu, W., Fang, W., Tang, S., Xin, H., Xie, J., & Zhang, H. (2019) · Livestock Science · doi:10.1016/j.livsci.2019.103857 · Cited by 24
Ibrahim, R. Y. M., Saber, A. A., & Hammad, H. B. I. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11036-z · Cited by 21
Zupo, R., Castellana, F., Sardone, R., Lampignano, L., Paradiso, S., Giagulli, V. A., Triggiani, V., Lorenzo, L. D., Giannelli, G., & Pergola, G. D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.565065 · Cited by 21
Bisphenols alter thermal responses and performance in zebrafish (Danio rerio)
Wu, N. C., & Seebacher, F. (2020) · Conservation Physiology · doi:10.1093/conphys/coaa138 · Cited by 21
Wang, K., Chen, F., Wang, J., & Liu, H. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.07.025 · Cited by 23
Effects of thyroid hormones in skeletal muscle protein turnover
Nappi, A., Moriello, C., Morgante, M., Fusco, F., Crocetto, F., & Miro, C. (2024) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2024-0139 · Cited by 24
Resmetirom: the first approved therapy for treating metabolic dysfunction associated steatohepatitis
Bhushan, S. R., Sohal, A., Noureddin, M., & Kowdley, K. V. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2478917 · Cited by 20
Gorini, F., Tonacci, A., Sanmartin, C., & Venturi, F. (2025) · Toxics · doi:10.3390/toxics13030222 · Cited by 22
Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage
Muter, J., Kong, C., Nebot, M. T., Tryfonos, M., Vrljicak, P., Brighton, P. J., Dimakou, D. B., Vickers, M., Yoshihara, H., Ott, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv1988 · Cited by 21
Barboza, S. D. C. R., de Oliveira, J. S., Souza, M. T. D. C., Júnior, D. M. D. L., Lima, H. B., & Guerra, R. R. (2019) · Tropical Animal Health and Production · doi:10.1007/s11250-019-01863-9 · Cited by 20
Obesity‐Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1
Zhou, J., Ren, Y., Xu, Q., Song, Y., Zhou, F., Chen, M., Liu, J., Chen, L., & Pan, J. (2020) · BioMed Research International · doi:10.1155/2020/4087928 · Cited by 21
Thyroid Status and Brain Circulation: The Rotterdam Study
Fani, L., Dueñas, O. H. R., Bos, D., Vernooij, M. W., Klaver, C. C. W., Ikram, M. K., Peeters, R. P., Ikram, M. A., & Chaker, L. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab744 · Cited by 20
Souissi, A., Dergaa, I., Chtourou, H., & Saad, H. B. (2022) · American Journal of Men s Health · doi:10.1177/15579883211070383 · Cited by 20
Huang, J., Chen, M., Liang, Y., Hu, Y., Xia, W., Zhang, Y., Zhao, C., & Wu, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1001349 · Cited by 20
Ramezani, M., Reisian, M., & Hezaveh, Z. S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0277213 · Cited by 21
Ye, Y., Li, Y., Ma, Q., Li, Y., Zeng, H., Luo, Y., Liang, Y., Liu, L., Liu, L., Xu, L., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1134208 · Cited by 21
Brain hypothyroidism silences the immune response of microglia in Alzheimer’s disease animal model
Kim, D. K., Choi, H., Lee, W., Choi, H., Hong, S. B., Jeong, J., Han, J., Han, J. W., Ryu, H., Kim, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adi1863 · Cited by 19
Mohr, S. M., Pra, R. D., Platt, M. P., Feketa, V. V., Shanabrough, M., Varela, L., Kristant, A., Cao, H., Merriman, D. K., Horváth, T. L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49996-2 · Cited by 22
Angelis, M. D., Giesert, F., Finan, B., Clemmensen, C., Müller, T. D., Weisenhorn, D. M. V., Tschöp, M. H., & Schramm, K. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.08.037 · Cited by 20
McCormley, M. C., Champagne, C. D., Deyarmin, J. S., Stephan, A. P., Crocker, D. E., Houser, D. S., & Khudyakov, J. I. (2018) · Conservation Physiology · doi:10.1093/conphys/coy040 · Cited by 20
Zak, M. A., & Manzon, R. G. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.02.001 · Cited by 20
Steinhoff, L., Jung, K., Meyerholz, M., Heidekorn-Dettmer, J., Hoedemaker, M., & Schmicke, M. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.01.023 · Cited by 20
Minakhina, S., Oliveira, V. D., Kim, S. Y., Zheng, H., & Wondisford, F. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107943118 · Cited by 22
Blood biochemistry, thyroid hormones, and performance in broilers with ascites caused by caffeine
Kamely, M., Torshizi, M. A. K., & Rahimi, S. (2016) · Poultry Science · doi:10.3382/ps/pew227 · Cited by 20
Preoperative thyroid function and weight loss after bariatric surgery
AMTCO Group, Neves, J. S., Souteiro, P., Oliveira, S. C., Pedro, J. M. P., Magalhães, D. M. D. S., Guerreiro, V. A., Costa, M. M., Bettencourt‐Silva, R., Santos, A. C., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0071-8 · Cited by 20
Calcaterra, V., Magenes, V. C., Siccardo, F., Hruby, C., Basso, M., Conte, V., Maggioni, G., Fabiano, V., Russo, S., Veggiotti, P., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1205331 · Cited by 20
Molecular Basis of Na, K–ATPase Regulation of Diseases: Hormone and FXYD2 Interactions
Cordeiro, B. M., Fontes, C. F. L., & Meyer‐Fernandes, J. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413398 · Cited by 19
Zhao, T., Shen, Q., Li, X., & Huan, T. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c12698 · Cited by 21
Boulos, M., Mousa, R. S., Jeries, N., Simaan, E., Alam, K., Bulus, B., & Assy, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073448 · Cited by 22
Chemie und Biologie der Schilddrüsenhormon‐Biosynthese und ‐Wirkung
Mondal, S., Raja, K., Schweizer, U., & Mugesh, G. (2016) · Angewandte Chemie · doi:10.1002/ange.201601116 · Cited by 19
Sarraude, T., Hsu, B., Groothuis, T. G. G., & Ruuskanen, S. (2020) · Physiological and Biochemical Zoology · doi:10.1086/709030 · Cited by 19
Effects of Hyperthyroidism on Adipose Tissue Activity and Distribution in Adults
Steinhoff, K. G., Krause, K., Linder, N., Rullmann, M., Volke, L., Gebhardt, C., Busse, H., Stümvoll, M., Blüher, M., Sabri, O., et al. (2020) · Thyroid · doi:10.1089/thy.2019.0806 · Cited by 19
Nonalcoholic Fatty Liver Disease and Hypothyroidism: What You Need to Know
Bikeyeva, V., Abdullah, A., Radivojevic, A., Jad, A. A. A., Ravanavena, A., Ravindra, C., Igweonu-Nwakile, E. O., Ali, S., Paul, S., Yakkali, S., et al. (2022) · Cureus · doi:10.7759/cureus.28052 · Cited by 19
Exposure to multiple trace elements and thyroid cancer risk in Chinese adults: A case-control study
He, J., Wu, H., Hu, W., Liu, J., Zhang, Q., Xiao, W. L., Hu, M., Wu, M., & Huang, F. (2022) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2022.114049 · Cited by 19
Vidal, É. K. D. S., Henrique, G., Silva, R. E. C., & Serrano‐Nascimento, C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.995491 · Cited by 19
Bayraktar, B., Tekçe, E., Bayraktar, S., Böyük, G., Takma, Ç., Aksakal, V., Genç, M., Kaya, H., Ülker, U., & Gürbüz, A. B. (2023) · Revista Brasileira de Zootecnia · doi:10.37496/rbz5220210040 · Cited by 19
Hypermetabolism in mice carrying a near-complete human chromosome 21
Sarver, D. C., Xu, C., Rodriguez, S., Aja, S. M., Jaffe, A. E., Gao, F., Delannoy, M. R., Periasamy, M., Kazuki, Y., Oshimura, M., et al. (2023) · eLife · doi:10.7554/elife.86023 · Cited by 18
Shen, X., Zhao, X., He, H., Zhang, Y., Zhu, Q. C., & Yin, H. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103241 · Cited by 19
Li, S., Li, X., Wang, K., Li, Y., Nagaoka, K., & Li, C. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00950-0 · Cited by 20
Metadata
- Authors
- Mullur, R., Liu, Y.-Y., & Brent, G. A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Brent, Gregory A.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2014-04
- Volume
- 94
- Issue
- 2
- Pages
- 355-382
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC4044302
- OpenAlex
- W1966824338
- Cited by
- 2,421
- References
- 292
- Citations by year
- 2026: 223 · 2025: 273 · 2024: 300 · 2023: 273 · 2022: 269 · 2021: 237 · 2020: 254 · 2019: 163 · 2018: 132 · 2017: 118 · 2016: 90 · 2015: 60 · 2014: 27
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (F32CA090073)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK98576, R01DK098576)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- thyroid hormones, thyroid hormone receptor, triiodothyronine, adaptive thermogenesis, brown adipose tissue, hypothalamus, thyrotropin-releasing hormone, thyroid-stimulating hormone, leptin, appetite regulation, adrenergic system, peroxisome proliferator-activated receptors, liver X receptor, bile acid signaling, hepatic insulin sensitivity, hepatic gluconeogenesis, cholesterol metabolism, carbohydrate metabolism, metabolic disorders
- MeSH terms
- Animals, Body Weight, Cholesterol, Energy Metabolism, Humans, Thyroid Gland, Thyroid Hormones, Triglycerides, Signal Transduction, Thermogenesis, Carbohydrate Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review