Comparative Transcriptomic Analysis of the Pituitary Gland between Cattle Breeds Differing in Growth: Yunling Cattle and Leiqiong Cattle
Open accessAbstract
The hypothalamic–pituitary–thyroid (HPT) axis hormones regulate the growth and development of ruminants, and the pituitary gland plays a decisive role in this process. In order to identify pivotal genes in the pituitary gland that could affect the growth of cattle by regulating the secretion of hormones, we detected the content of six HPT hormones related to growth in the plasma of two cattle breeds (Yunling and Leiqiong cattle, both also known as the zebu cattle) with great differences in growth and compared the transcriptome data of their pituitary glands. Our study found that the contents of GH, IGF, TSH, thyroxine, triiodothyronine, and insulin were significantly different between the two breeds, which was the main cause of the difference in growth; 175 genes were identified as differentially expressed genes (DEGs). Functional association analyses revealed that DEGs were mainly involved in the process of transcription and signal transduction. Combining the enrichment analysis and protein interaction analysis, eight DEGs were predicted to control the growth of cattle by affecting the expression of growth-related hormones in the pituitary gland. In summary, our results suggested that SLC38A1, SLC38A3, DGKH, GNB4, GNAQ, ESR1, NPY, and GAL are candidates in the pituitary gland for regulating the growth of Yunling and Leiqiong cattle by regulating the secretion of growth-related hormones. This study may help researchers further understand the growth mechanisms and improve the artificial selection of zebu cattle.
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A transcriptome study of pituitaries from fast-growing Yunling cattle and slow-growing Leiqiong cattle identified candidate genes involved in growth hormone regulation.
“A transcriptome study of pituitaries from fast-growing Yunling cattle and slow-growing Leiqiong cattle identified candidate genes involved in growth hormone regulation, including SLC38A1, SLC38A3, DGKH, GNB4, GNAQ, ESR1, NPY, and GAL [174].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [174]
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- Authors
- Lu, X., Arbab, A. A. I., Zhang, Z., Fan, Y., Han, Z., Gao, Q., Sun, Y., & Yang, Z.
- Affiliations
- Yangzhou University (CN)
- Corresponding author
- Yang, Zhangping
- Venue
- Animals
- Publisher
- MDPI AG
- Published
- 2020-07-25
- Volume
- 10
- Issue
- 8
- Pages
- 1271
- ISSN
- 2076-2615 (ISSN-L)
- PMC
- PMC7460210
- OpenAlex
- W3045326167
- Cited by
- 22
- References
- 79
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animals (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Earmarked Fund for Jiangsu Agricultural Industry Technology (System : JATS [2019]446)
- National Natural Science Foundation of China (31872324, 31902147)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- pituitary gland, hypothalamic-pituitary-thyroid axis, cattle growth, Bos indicus, differentially expressed genes, growth hormone, insulin-like growth factor, thyroxine, triiodothyronine, thyroid-stimulating hormone, insulin, SLC38A1, GNB4, GNAQ, ESR1, neuropeptide Y, GAL, growth regulation, selective breeding
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