The DOI matches its Crossref record; 248 of the 248 references it cites were found in a registry or an index.
Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
Abstract
The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproductive cycle. These changes are fueled by dedicated stem and progenitor cells. Both short- and long-lived lineage-restricted progenitors have been identified in adult tissue as well as a small pool of multipotent mammary stem cells (MaSCs), reflecting intrinsic complexity within the epithelial hierarchy. While unipotent progenitor cells predominantly execute day-to-day homeostasis and postnatal morphogenesis during puberty and pregnancy, multipotent MaSCs have been implicated in coordinating alveologenesis and long-term ductal maintenance. Nonetheless, the multipotency of stem cells in the adult remains controversial. The advent of large-scale single-cell molecular profiling has revealed striking changes in the gene expression landscape through ontogeny and the presence of transient intermediate populations. An increasing number of lineage cell-fate determination factors and potential niche regulators have now been mapped along the hierarchy, with many implicated in breast carcinogenesis. The emerging diversity among stem and progenitor populations of the mammary epithelium is likely to underpin the heterogeneity that characterizes breast cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–248 of 248
Chiche, A., Moumen, M., Petit, V., Jonkers, J., Medina, D., Deugnier, M., Faraldo, M. M., & Glukhova, M. A. (2013) · Stem Cells · doi:10.1002/stem.1429 · Cited by 55
Lineage Specific Methylation of the Elf5 Promoter in Mammary Epithelial Cells
Lee, H. J., Hinshelwood, R. A., Bouras, T., Gallego‐Ortega, D., Valdés‐Mora, F., Blazek, K. D., Visvader, J. E., Clark, S. J., & Ormandy, C. J. (2011) · Stem Cells · doi:10.1002/stem.706 · Cited by 55
Self-citationVaillant, F., Lindeman, G. J., & Visvader, J. E. (2011) · Breast Cancer Research · doi:10.1186/bcr2851 · Cited by 55
Self-citationMammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities
Casey, A. E., Sinha, A., Singhania, R., Livingstone, J. M., Waterhouse, P. D., Tharmapalan, P., Cruickshank, J., Shehata, M., Drysdale, E., Fang, H., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201804042 · Cited by 54
Michalak, E. M., Nacerddine, K., Pietersen, A. M., Beuger, V., Pawlitzky, I., Cornelissen‐Steijger, P., Wientjens, E., Tanger, E., Seibler, J., van Lohuizen, M., et al. (2013) · Stem Cells · doi:10.1002/stem.1437 · Cited by 53
Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC
Ballard, M. S., Zhu, A., Iwai, N., Stensrud, M., Mapps, A. A., Postiglione, M. P., Knoblich, J. A., & Hinck, L. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.006 · Cited by 51
Lindley, L. E., Curtis, K. M., Sánchez-Mejías, A., Rieger, M. E., Robbins, D. J., & Briegel, K. J. (2015) · Development · doi:10.1242/dev.110403 · Cited by 50
Paine, I. S., Chauvière, A., Landua, J. D., Sreekumar, A., Vittorio Cristini, C., Rosen, J. M., & Lewis, M. T. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004839 · Cited by 50
Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells
Zhang, L., Adileh, M., Martín, M. L., Klingler, S., White, J. R., Ma, X., Howe, L. R., Brown, A. M. C., & Kolesnick, R. N. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.08.001 · Cited by 50
Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress
Hein, S., Haricharan, S., Johnston, A. N., Toneff, M. J., Reddy, J. P., Dong, J., Bu, W., & Li, Y. (2015) · Oncogene · doi:10.1038/onc.2015.206 · Cited by 49
Malhotra, G. K., Zhao, X., Edwards, E., Kopp, J. L., Naramura, M., Sander, M., Band, H., & Band, V. (2014) · BMC Developmental Biology · doi:10.1186/s12861-014-0047-4 · Cited by 49
Sreekumar, A., Toneff, M. J., Toh, E., Roarty, K. P., Creighton, C. J., Belka, G. K., Lee, D.-K., Xu, J., Chodosh, L. A., Richards, J. S., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.10.007 · Cited by 49
Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours
Tao, L., Xiang, D., Xie, Y., Bronson, R. T., & Li, Z. (2017) · Nature Communications · doi:10.1038/ncomms14431 · Cited by 47
Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes
Yoo, K. H., Oh, S., Kang, K., Hensel, T., Robinson, G. W., & Hennighausen, L. G. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv776 · Cited by 45
ID4 regulates mammary gland development by suppressing p38MAPK activity
Dong, J., Huang, S., Čaikovski, M., Ji, S., McGrath, A., Custorio, M. G., Creighton, C. J., Maliakkal, P., Bogoslovskaia, E., Du, Z., et al. (2011) · Development · doi:10.1242/dev.069203 · Cited by 45
Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells
Lloyd‐Lewis, B., Davis, F. M., Harris, O. B., Hitchcock, J. R., & Watson, C. J. (2018) · Development · doi:10.1242/dev.164079 · Cited by 45
Bruno, R. D., Fleming, J. M., George, A. L., et al. (2017) · Scientific Reports · doi:10.1038/srep40196 · Cited by 44
Yallowitz, A. R., Alexandrova, E. M., Talos, F., Xu, S., Marchenko, N. D., & Moll, U. M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2013.199 · Cited by 43
Proof of region-specific multipotent progenitors in human breast epithelia
Fridriksdottir, A. J., Villadsen, R., Morsing, M., Klitgaard, M. C., Kim, J., Petersen, O. W., & Rønnov‐Jessen, L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714063114 · Cited by 43
Boras-Granic, K., Dann, P. R., & Wysolmerski, J. J. (2014) · Breast Cancer Research · doi:10.1186/s13058-014-0487-6 · Cited by 42
Élias, S., Morgan, M. A., Bikoff, E. K., & Robertson, E. J. (2017) · Nature Communications · doi:10.1038/s41467-017-01971-w · Cited by 42
Cagnet, S., Ataca, D., Sflomos, G., Aouad, P., Schuepbach‐Mallepell, S., Henry, H., Krust, A., Ayyanan, A., Scabia, V., & Brisken, C. (2018) · Nature Communications · doi:10.1038/s41467-018-07175-0 · Cited by 42
Boulanger, C. A., Bruno, R. D., Rosu‐Myles, M., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0148 · Cited by 41
Visbal, A. P., LaMarca, H. L., Villanueva, H. J., Toneff, M. J., Li, Y., Rosen, J. M., & Lewis, M. T. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.01.025 · Cited by 40
Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary
Best, S. A., Hutt, K. J., Fu, N. Y., Vaillant, F., Liew, S. H., Hartley, L., Scott, C. L., Lindeman, G. J., & Visvader, J. E. (2014) · Development · doi:10.1242/dev.108498 · Cited by 38
Self-citationThe complexities and caveats of lineage tracing in the mammary gland
Rios, A. C., Fu, N. Y., Cursons, J., Lindeman, G. J., & Visvader, J. E. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0774-5 · Cited by 38
Self-citationTrejo, C. L., Luna, G., Dravis, C., Spike, B. T., & Wahl, G. M. (2017) · npj Breast Cancer · doi:10.1038/s41523-017-0018-6 · Cited by 37
Mammary Stroma in Development and Carcinogenesis
Sakakura, T., Suzuki, Y., & Shiurba, R. (2013) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-013-9281-9 · Cited by 33
Oliver, C. H., Khaled, W. T., Frend, H. T., Nichols, J., & Watson, C. J. (2012) · Genes & Development · doi:10.1101/gad.184051.111 · Cited by 33
Di-Cicco, A., Petit, V., Chiche, A., Bresson, L., Romagnoli, M., Orian‐Rousseau, V., Vivanco, M. D., Medina, D., Faraldo, M. M., Glukhova, M. A., et al. (2015) · eLife · doi:10.7554/elife.06104 · Cited by 31
Wang, S., Liu, J. C., Kim, D., Datti, A., & Zacksenhaus, E. (2016) · Breast Cancer Research · doi:10.1186/s13058-015-0668-y · Cited by 31
Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1
Sizemore, G. M., Balakrishnan, S., Hammer, A. M., Thies, K., Trimboli, A. J., Wallace, J. A., Sizemore, S. T., Kladney, R. D., Woelke, S. A., Yu, L., et al. (2016) · Oncogene · doi:10.1038/onc.2016.383 · Cited by 30
A TGFβ–miR-182–BRCA1 axis controls the mammary differentiation hierarchy
Martinez‐Ruiz, H., Illa-Bochaca, I., Omene, C. O., Hanniford, D., Liu, Q., Hernando, E., & Barcellos‐Hoff, M. H. (2016) · Science Signaling · doi:10.1126/scisignal.aaf5402 · Cited by 30
Hormones induce the formation of luminal-derived basal cells in the mammary gland
Song, W., Wang, R., Jiang, W., Yin, Q., Peng, G., Yang, R., Yu, Q. C., Chen, J., Li, J., Cheung, T. H., et al. (2019) · Cell Research · doi:10.1038/s41422-018-0137-0 · Cited by 29
Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins
Romagnoli, M., Cagnet, S., Chiche, A., Bresson, L., Baulande, S., de la Grange, P., Arcangelis, A. D., Kreft, M., Georges‐Labouesse, E., Sonnenberg, A., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.02.008 · Cited by 29
Baker, L. A., Holliday, H., & Swarbrick, A. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0196 · Cited by 28
Dall, G., Vieusseux, J. L., Korach, K. S., Arao, Y., Hewitt, S. C., Hamilton, K. J., Dzierzak, E. A., Boon, W. C., Simpson, E. R., Ramsay, R. G., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.12.022 · Cited by 28
Tao, L., van Bragt, M. P. A., & Li, Z. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.05.014 · Cited by 27
Cereser, B., Jansen, M., Austin, E. E., Elia, G., McFarlane, T., van Deurzen, C., Sieuwerts, A. M., Daidone, M. G., Tadrous, P. J., Wright, N. A., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4989 · Cited by 27
Mapping mammary gland architecture using multi-scale in situ analysis
Fernández‐González, R., Illa-Bochaca, I., Welm, B. E., Fleisch, M. C., Werb, Z., Ortíz-de-Solórzano, C., & Barcellos‐Hoff, M. H. (2008) · Integrative Biology · doi:10.1039/b816933k · Cited by 24
Evidence for a multipotent mammary progenitor with pregnancy-specific activity
Kaanta, A. S., Virtanen, C., Selfors, L. M., Brugge, J. S., & Neel, B. G. (2013) · Breast Cancer Research · doi:10.1186/bcr3459 · Cited by 24
Regan, J. L., & Smalley, M. J. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-0017-3 · Cited by 23
Foxa1 is essential for mammary duct formation
Liu, Y., Zhao, Y., Skerry, B., Wang, X., Colin, C., Radisky, D. C., Kaestner, K. H., & Li, Z. (2016) · genesis · doi:10.1002/dvg.22929 · Cited by 23
Wnt4 is not sufficient to induce lobuloalveolar mammary development
Kim, Y. C., Clark, R. J., Pelegri, F. J., & Alexander, C. M. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-55 · Cited by 21
Bussard, K. M., Boulanger, C. A., Kittrell, F. S., Behbod, F., Medina, D., & Smith, G. H. (2010) · Breast Cancer Research · doi:10.1186/bcr2754 · Cited by 20
Ahmed, M. I., Élias, S., Mould, A. W., Bikoff, E. K., & Robertson, E. J. (2016) · Development · doi:10.1242/dev.136358 · Cited by 18
Michalak, E. M., Milevskiy, M. J. G., Joyce, R., Dekkers, J. F., Jamieson, P. R., Pal, B., Dawson, C. A., Hu, Y., Orkin, S. H., Alexander, W. S., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2004986 · Cited by 18
Self-citationBoecker, W., van Horn, L., Stenman, G., Stürken, C., Schumacher, U., Loening, T., Liesenfeld, L. F., Korsching, E., Gläser, D., Tiemann, K., et al. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0054-3 · Cited by 17
Cited by
Breast milk, a source of beneficial microbes and associated benefits for infant health
Lyons, K. E., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2020) · Nutrients · doi:10.3390/nu12041039 · Cited by 613
Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing
Li, C. M.-C., Shapiro, H., Tsiobikas, C., Selfors, L. M., Chen, H., Rosenbluth, J., Moore, K., Gupta, K. P., Gray, G. K., Oren, Y., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108566 · Cited by 184
Metadata
- Authors
- Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2020-04-01
- Volume
- 100
- Issue
- 2
- Pages
- 489-523
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2974150138
- Cited by
- 267
- References
- 248
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
