The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Hypoxic Pulmonary Vasoconstriction
Open accessAbstract
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last 20 years, it has been clear that the essential sensor, transduction, and effector mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV) reside in the pulmonary arterial smooth muscle cell. The main focus of this review is the cellular and molecular work performed to clarify these intrinsic mechanisms and to determine how they are facilitated and inhibited by the extrinsic influences of other cells. Because the interaction of intrinsic and extrinsic mechanisms is likely to shape expression of HPV in vivo, we relate results obtained in cells to HPV in more intact preparations, such as intact and isolated lungs and isolated pulmonary vessels. Finally, we evaluate evidence regarding the contribution of HPV to the physiological and pathophysiological processes involved in the transition from fetal to neonatal life, pulmonary gas exchange, high-altitude pulmonary edema, and pulmonary hypertension. Although understanding of HPV has advanced significantly, major areas of ignorance and uncertainty await resolution.
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
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The versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“vHL binding requires hydroxylation of proline residues on HIF-1 by prolyl hydroxylase domain proteins (PHD), members of the Fe(II) and 2-oxoglutarate-requiring dioxygenase family (867, 875).”
Background
Cited by
Gas exchange and ventilation–perfusion relationships in the lung
Petersson, J., & Glenny, R. W. (2014) · European Respiratory Journal · doi:10.1183/09031936.00037014 · Cited by 391
Pulmonary Vascular Hemodynamic Response to Exercise in Cardiopulmonary Diseases
Lewis, G. D., Bossone, E., Naeije, R., Grünig, E., Saggar, R., Lancellotti, P., Ghio, S., Varga, J., Rajagopalan, S., Oudiz, R., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000667 · Cited by 386
Al-Mehdi, A.-B., Pastukh, V. M., Swiger, B. M., Reed, D. J., Patel, M. R., Bardwell, G. C., Pastukh, V. V., Alexeyev, M. F., & Gillespie, M. N. (2012) · Science Signaling · doi:10.1126/scisignal.2002712 · Cited by 386
Metabolism of vascular smooth muscle cells in vascular diseases
Shi, J., Yang, Y., Cheng, A., Xu, G., & He, F. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00220.2020 · Cited by 366
Superoxide generation by complex III: From mechanistic rationales to functional consequences
Bleier, L., & Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.12.002 · Cited by 369
Metadata
- Authors
- Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., & Ward, J. P. T.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2012-01
- Volume
- 92
- Issue
- 1
- Pages
- 367-520
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2112861506
- Cited by
- 725
- References
- 51
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- green
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