CoChat
Sign Up
Cited by 936Cardiovascular and exercise physiologyCardiac Imaging and DiagnosticsNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 644 of the 646 references it cites were found in a registry or an index.

Regulation of Coronary Blood Flow During Exercise

Duncker, Dirk J., Bache, Robert J.·2008·Physiological Reviews
DOI 10.1152/physrev.00045.2006
Open this paper in CoChat — free account

Abstract

Exercise is the most important physiological stimulus for increased myocardial oxygen demand. The requirement of exercising muscle for increased blood flow necessitates an increase in cardiac output that results in increases in the three main determinants of myocardial oxygen demand: heart rate, myocardial contractility, and ventricular work. The approximately sixfold increase in oxygen demands of the left ventricle during heavy exercise is met principally by augmenting coronary blood flow (~5-fold), as hemoglobin concentration and oxygen extraction (which is already 70-80% at rest) increase only modestly in most species. In contrast, in the right ventricle, oxygen extraction is lower at rest and increases substantially during exercise, similar to skeletal muscle, suggesting fundamental differences in blood flow regulation between these two cardiac chambers. The increase in heart rate also increases the relative time spent in systole, thereby increasing the net extravascular compressive forces acting on the microvasculature within the wall of the left ventricle, in particular in its subendocardial layers. Hence, appropriate adjustment of coronary vascular resistance is critical for the cardiac response to exercise. Coronary resistance vessel tone results from the culmination of myriad vasodilator and vasoconstrictors influences, including neurohormones and endothelial and myocardial factors. Unraveling of the integrative mechanisms controlling coronary vasodilation in respons…

Overview

Integrity signals

Registry

Crossref · 10.1152/physrev.00045.2006

Cites

644 of 644 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

2 of the 646 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Rowell LB . Cardiovascular adaptations to chronic physical activity and inactivity. In: Human Circulation. New York: Oxford Univ. Press, 1986, p. 257–286.

Cited by

Sorted by citations

See all 936

Related

See all

Metadata

Authors
Duncker, D. J., & Bache, R. J.
Affiliations
Erasmus MC (NL)
ORCID
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2008-07
Volume
88
Issue
3
Pages
1009-1086
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00045.2006
OpenAlex
W2134256354
Cited by
936
References
646
Citations by year
2026: 44 · 2025: 49 · 2024: 50 · 2023: 53 · 2022: 55 · 2021: 69 · 2020: 40 · 2019: 45 · 2018: 57 · 2017: 61 · 2016: 36 · 2015: 50 · 2014: 48 · 2013: 66 · 2012: 60
FWCI
8.93
Type
journal article
Language
en
Open access
closed
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
coronary blood flow, physical activity, myocardial oxygen demand, coronary vasodilation, coronary microcirculation, exercise training, capillary density, adrenergic tone, nitric oxide synthase, endothelium-dependent vasodilation, myogenic tone, protein kinase C, nitric oxide, cardiac output, coronary vascular resistance
MeSH terms
Adaptation, Physiological, Animals, Collateral Circulation, Coronary Circulation, Hemodynamics, Humans, Models, Cardiovascular, Oxygen Consumption, Exercise, Ventricular Function, Coronary Stenosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review