The DOI matches its Crossref record; 644 of the 646 references it cites were found in a registry or an index.
Regulation of Coronary Blood Flow During Exercise
Abstract
Exercise is the most important physiological stimulus for increased myocardial oxygen demand. The requirement of exercising muscle for increased blood flow necessitates an increase in cardiac output that results in increases in the three main determinants of myocardial oxygen demand: heart rate, myocardial contractility, and ventricular work. The approximately sixfold increase in oxygen demands of the left ventricle during heavy exercise is met principally by augmenting coronary blood flow (~5-fold), as hemoglobin concentration and oxygen extraction (which is already 70-80% at rest) increase only modestly in most species. In contrast, in the right ventricle, oxygen extraction is lower at rest and increases substantially during exercise, similar to skeletal muscle, suggesting fundamental differences in blood flow regulation between these two cardiac chambers. The increase in heart rate also increases the relative time spent in systole, thereby increasing the net extravascular compressive forces acting on the microvasculature within the wall of the left ventricle, in particular in its subendocardial layers. Hence, appropriate adjustment of coronary vascular resistance is critical for the cardiac response to exercise. Coronary resistance vessel tone results from the culmination of myriad vasodilator and vasoconstrictors influences, including neurohormones and endothelial and myocardial factors. Unraveling of the integrative mechanisms controlling coronary vasodilation in respons…
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“Moderate-intensity activities done for durations of less than 1 min might not be long enough to induce pronounced changes to the coronary vasculature when compared with longer bouts.28,29”
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Cites
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2 of the 646 references couldn’t be matched to a known paper.
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- Rowell LB . Cardiovascular adaptations to chronic physical activity and inactivity. In: Human Circulation. New York: Oxford Univ. Press, 1986, p. 257–286.
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Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Coronary Microvascular Dysfunction
Crea, F., Lanza, G. A., & Camici, P. G. (2013) · Springer eBooks · doi:10.1007/978-88-470-5367-0 · Cited by 1,295
Joyner, M. J., & Casey, D. P. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2013 · Cited by 833
Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli
Green, D. J., Hopman, M. T. E., Padilla, J., Laughlin, M. H., & Thijssen, D. H. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00014.2016 · Cited by 821
Exercise and the Cardiovascular System: Clinical Science and Cardiovascular Outcomes
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Metadata
- Authors
- Duncker, D. J., & Bache, R. J.
- Affiliations
- Erasmus MC (NL)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 88
- Issue
- 3
- Pages
- 1009-1086
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2134256354
- Cited by
- 936
- References
- 646
- Citations by year
- 2026: 44 · 2025: 49 · 2024: 50 · 2023: 53 · 2022: 55 · 2021: 69 · 2020: 40 · 2019: 45 · 2018: 57 · 2017: 61 · 2016: 36 · 2015: 50 · 2014: 48 · 2013: 66 · 2012: 60
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- coronary blood flow, physical activity, myocardial oxygen demand, coronary vasodilation, coronary microcirculation, exercise training, capillary density, adrenergic tone, nitric oxide synthase, endothelium-dependent vasodilation, myogenic tone, protein kinase C, nitric oxide, cardiac output, coronary vascular resistance
- MeSH terms
- Adaptation, Physiological, Animals, Collateral Circulation, Coronary Circulation, Hemodynamics, Humans, Models, Cardiovascular, Oxygen Consumption, Exercise, Ventricular Function, Coronary Stenosis
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