Mammalian Krüppel-Like Factors in Health and Diseases

Loss of LKLF Function Results in Embryonic Lethality in Mice

Wani, M. A., Means, R. T., & Lingrel, J. B. (1998) · Transgenic Research · doi:10.1023/a:1008809809843 · Cited by 138

Deletion, Mutation, and Loss of Expression of KLF6 in Human Prostate Cancer

Chen, C., Hyytinen, E., Sun, X., Helin, H. J., Koivisto, P. A., Frierson, H. F., Vessella, R. L., & Dong, J. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63930-2 · Cited by 137

Ubiquitin–proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells

Chen, C., Sun, X., Ran, Q., Wilkinson, K. D., Murphy, T. J., Simons, J. W., & Dong, J. (2005) · Oncogene · doi:10.1038/sj.onc.1208497 · Cited by 137

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal Tumorigenesis

Nandan, M. O., McConnell, B. B., Ghaleb, A. M., Bialkowska, A. B., Sheng, H., Shao, J., Babbin, B. A., Robine, S., & Yang, V. W. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.023 · Cited by 136

Kruppel-Like Factor 6 Is Frequently Down-Regulated and Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Ito, G., Uchiyama, M., Kondo, M., Mori, S., Usami, N., Maeda, O., Kawabe, T., Hasegawa, Y., Shimokata, K., & Sekido, Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0185 · Cited by 136

BTEB2, a Kruppel-Like Transcription Factor, Regulates Expression of the SMemb/Nonmuscle Myosin Heavy Chain B (SMemb/NMHC-B) Gene

Watanabe, N., Kurabayashi, M., Shimomura, Y., Kawai‐Kowase, K., Hoshino, Y.-I., Manabe, I., Watanabe, M., Aikawa, M., Kuro‐o, M., Suzuki, T., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.2.182 · Cited by 136

Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras

Nandan, M. O., Yoon, H. S., Zhao, W., Ouko, L., Chanchevalap, S., & Yang, V. W. (2004) · Oncogene · doi:10.1038/sj.onc.1207397 · Cited by 134

Oxidized Phospholipids Induce Type VIII Collagen Expression and Vascular Smooth Muscle Cell Migration

Cherepanova, O. A., Pidkovka, N. A., Sarmento, O. F., Yoshida, T., Gan, Q., Adiguzel, E., Bendeck, M. P., Berliner, J. A., Leitinger, N., & Owens, G. K. (2009) · Circulation Research · doi:10.1161/circresaha.108.186064 · Cited by 133

Two Potent Nuclear Localization Signals in the Gut-enriched Krüppel-like Factor Define a Subfamily of Closely Related Krüppel Proteins

Shields, J. M., & Yang, V. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18504 · Cited by 133

Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2

Tuomisto, T. T., Lumivuori, H., Kansanen, E., Häkkinen, S.-K., Turunen, M. P., van Thienen, J. V., Horrevoets, A. J. G., Levonen, A., & Ylä‐Herttuala, S. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn007 · Cited by 133

TGFβ inducible early gene enhances TGFβ/Smad-dependent transcriptional responses

Johnsen, S. A., Subramaniam, M., Janknecht, R., & Spelsberg, T. C. (2002) · Oncogene · doi:10.1038/sj.onc.1205681 · Cited by 132

The Absence of LPA2 Attenuates Tumor Formation in an Experimental Model of Colitis-Associated Cancer

Lin, S., Wang, D., Iyer, S. S., Ghaleb, A. M., Shim, H., Yang, V. W., Chun, J. J. M., & Yun, C. C. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.002 · Cited by 130

Requirement of Krüppel-like Factor 4 in Preventing Entry into Mitosis following DNA Damage

Yoon, H. S., & Yang, V. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307631200 · Cited by 130

KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1

Wu, J., & Lingrel, J. (2004) · Oncogene · doi:10.1038/sj.onc.1207996 · Cited by 128

Overexpression of Kruppel-Like Factor 7 Regulates Adipocytokine Gene Expressions in Human Adipocytes and Inhibits Glucose-Induced Insulin Secretion in Pancreatic β-Cell Line

Kawamura, Y., Tanaka, Y., Kawamori, R., & Maeda, S. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0138 · Cited by 128

Kruppel-like factor 5 is required for perinatal lung morphogenesis and function

Wan, H., Luo, F., Wert, S. E., Zhang, L., Xu, Y. J., Ikegami, M., Maeda, Y., Bell, S. M., & Whitsett, J. A. (2008) · Development · doi:10.1242/dev.021964 · Cited by 128

Decreased expression of Krüppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses

Good‐Jacobson, K. L., & Tangye, S. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703872104 · Cited by 128

Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Krüppel-like factor

Hinnebusch, B. F., Siddique, A., Henderson, J. W., Malo, M. S., Zhang, W., Athaide, C. P., Abedrapo, M. A., Chen, X., Yang, V. W., & Hodin, R. A. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2003 · Cited by 128

Transcriptome Analysis of Human Colon Caco-2 Cells Exposed to Sulforaphane

Τράκα, Μ., Gasper, A. V., Smith, J. A., Hawkey, C. J., Bao, Y., & Mithen, R. F. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.1865 · Cited by 128

Positive and Negative Regulation of the Cardiovascular Transcription Factor KLF5 by p300 and the Oncogenic Regulator SET through Interaction and Acetylation on the DNA-Binding Domain

Miyamoto, S., Suzuki, T., Muto, S., Aizawa, K., Kimura, A., Mizuno, Y., Nagino, T., Imai, Y., Adachi, N., Horikoshi, M., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8528-8541.2003 · Cited by 128

Roles of Kruppel-like factor 4 in normal homeostasis, cancer and stem cells

Paul, P., Evans, Chunming, & Liu (2008) · 生物化学与生物物理学报：英文版 · Cited by 128

Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2

Dang, D. T., Mahatan, C. S., Dang, L. H., Agboola, I. A., & Yang, V. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204645 · Cited by 127

Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction

Geiman, D. E. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.5.1106 · Cited by 127

Conditional Deletion of the Mouse Klf4 Gene Results in Corneal Epithelial Fragility, Stromal Edema, and Loss of Conjunctival Goblet Cells

Swamynathan, S. K., Katz, J. P., Kaestner, K. H., Ashery‐Padan, R., Crawford, M. A., & Piatigorsky, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00846-06 · Cited by 127

Gene Expression in Antigen-Specific CD8+ T Cells During Viral Infection

Grayson, J. M., Murali‐Krishna, K., Altman, J. D., & Ahmed, R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.795 · Cited by 126

Krüppel-like Factor 4 (KLF4/GKLF) Is a Target of Bone Morphogenetic Proteins and Transforming Growth Factor β1 in the Regulation of Vascular Smooth Muscle Cell Phenotype

King, K. E., Iyemere, V., Weissberg, P. L., & Shanahan, C. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211337200 · Cited by 125

Cloning the cDNA for a New Human Zinc Finger Protein Defines a Group of Closely Related Krüppel-like Transcription Factors

Matsumoto, N., Laub, F., Aldabe, R., Zhang, W., Ramirez, F., Yoshida, T., & Terada, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28229 · Cited by 124

Intestinal Tumor Progression Is Associated with Altered Function of KLF5

Bateman, N. W., Tan, D., Pestell, R. G., Black, J. D., & Black, A. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311532200 · Cited by 123

Three Conserved Transcriptional Repressor Domains Are a Defining Feature of the TIEG Subfamily of Sp1-like Zinc Finger Proteins

Cook, T. A., Gebelein, B. A., Belal, M., Mesa, K., & Urrutia, R. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29500 · Cited by 123

Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1.

Crossley, M., Tsang, A. P., Bieker, J. J., & Orkin, S. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40698-3 · Cited by 122

KLF5 Interacts with p53 in Regulating Survivin Expression in Acute Lymphoblastic Leukemia

Zhu, N., Gu, L., Findley, H. W., Chen, C., Dong, J., Yang, L. P. H., & Zhou, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513810200 · Cited by 122

KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract

Zheng, H., Pritchard, D. M., Yang, X., Bennett, E., Liu, G., Liu, C., & Ai, W. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90393.2008 · Cited by 122

KLF2 Suppresses TGF-β Signaling in Endothelium Through Induction of Smad7 and Inhibition of AP-1

Boon, R. A., Fledderus, J. O., Volger, O. L., van Wanrooij, E. J. A., Pardali, E., Weesie, F., Kuiper, J., Pannekoek, H., ten Dijke, P., & Horrevoets, A. J. G. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000256466.65450.ce · Cited by 121

Notch Inhibits Expression of the Krüppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium

Ghaleb, A. M., Aggarwal, G., Bialkowska, A. B., Nandan, M. O., & Yang, V. W. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0224 · Cited by 121

The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1

Brembeck, F. H., & Rustgi, A. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004013200 · Cited by 120

Expression of KLF5 is a Prognostic Factor for Disease-Free Survival and Overall Survival in Patients with Breast Cancer

Castillo‐Tong, D. C., Czerwenka, K. F., Heinze, G., Ryffel, M., Schuster, E., Witt, A., Leodolter, S., & Zeillinger, R. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0964 · Cited by 120

Transcriptional Regulation of the CLC-K1 Promoter by myc-Associated Zinc Finger Protein and Kidney-Enriched Krüppel-Like Factor, a Novel Zinc Finger Repressor

Uchida, S., Tanaka, Y., Ito, H., Saito-Ohara, F., Inazawa, J., Yokoyama, K. K., Sasaki, S., & Marumo, F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7319-7331.2000 · Cited by 120

Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells

伊藤, 源. (2005) · 名古屋大学 eBooks · Cited by 119

Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma

Hu, W., Hofstetter, W. L., Li, H., Zhou, Y., He, Y., Pataer, A., Wang, L., Xie, K., Swisher, S. G., & Fang, B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0310 · Cited by 118

Profiling and Verification of Gene Expression Patterns in Normal and Malignant Human Prostate Tissues by cDNA Microarray Analysis

Chaı̈b, H., Cockrell, E. K., Rubin, M. A., & Macoska, J. A. (2001) · Neoplasia · doi:10.1038/sj.neo.7900126 · Cited by 117

The KLF2 Transcription Factor Does Not Affect the Formation of Preadipocytes but Inhibits Their Differentiation into Adipocytes

Wu, J., Srinivasan, S. V., Neumann, J. C., & Lingrel, J. B. (2005) · Biochemistry · doi:10.1021/bi050166i · Cited by 117

Human KLF17 is a new member of the Sp/KLF family of transcription factors

van Vliet, J., Crofts, L. A., Quinlan, K. G. R., Czolij, R., Perkins, A. C., & Crossley, M. (2006) · Genomics · doi:10.1016/j.ygeno.2005.12.011 · Cited by 117

(−)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells

Cho, S. Y., Park, P. J., Shin, H. J., Kim, Y. K., Shin, D. W., Shin, E. S., Lee, H. H., Lee, B. G., Baik, J.-H., & Lee, T. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00436.2006 · Cited by 117

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

Liu, N., Li, H., Li, S., Shen, M., Xiao, N., Chen, Y., Wang, Y., Wang, W., Wang, R., Wang, Q., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.099440 · Cited by 116

The Erythroid Krüppel-Like Factor Transactivation Domain is a Critical Component for Cell-Specific Inducibility of a β-Globin Promoter

Bieker, J. J., & Southwood, C. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.852 · Cited by 115

Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells.

Kojima, S., Hayashi, S., Shimokado, K., Suzuki, Y., Shimada, J., Crippa, M. P., & Friedman, S. L. (2000) · PubMed · Cited by 114

Lung Kruppel-like Factor, a Zinc Finger Transcription Factor, Is Essential for Normal Lung Development

Wani, M. A., Wert, S. E., & Lingrel, J. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21180 · Cited by 114

Krüppel-like factor 4 exhibits antiapoptotic activity following γ-radiation-induced DNA damage

Ghaleb, A. M., Katz, J. P., Kaestner, K. H., Du, J. X., & Yang, V. W. (2006) · Oncogene · doi:10.1038/sj.onc.1210022 · Cited by 113

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis

Narla, G., DiFeo, A. V., Fernández, Y., Dhanasekaran, S. M., Huang, F., Sangodkar, J., Hod, E. A., Leake, D., Friedman, S. L., Hall, S. J., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34780 · Cited by 112

TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro

Subramaniam, M., Gorny, G., Johnsen, S. A., Monroe, D. G., Evans, G. L., Fraser, D. G., Rickard, D. J., Rasmussen, K., van Deursen, J. M. A., Turner, R. T., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1191-1199.2005 · Cited by 112

KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERα

Akaogi, K., Nakajima, Y., Ito, I., Kawasaki, S., Oie, S.-H., Murayama, A., Kimura, K., & Yanagisawa, J. (2009) · Oncogene · doi:10.1038/onc.2009.151 · Cited by 111

Selective Interactions of Krüppel-like Factor 9/Basic Transcription Element-binding Protein with Progesterone Receptor Isoforms A and B Determine Transcriptional Activity of Progesterone-responsive Genes in Endometrial Epithelial Cells

Zhang, X., Zhang, D., Michel, F. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212098200 · Cited by 109

Developmental Expression of Mouse Krüppel-like Transcription Factor KLF7 Suggests a Potential Role in Neurogenesis

Laub, F., Aldabe, R., Friedrich, V. L., Ohnishi, S., Yoshida, T., & Ramirez, F. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0243 · Cited by 108

EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation

Bouilloux, F., Juban, G., Cohet, N., Selimoglu‐Buet, D., Guyot, B., Vainchenker, W., Louache, F., & Morlé, F. (2008) · Blood · doi:10.1182/blood-2007-07-098996 · Cited by 108

Expression of the gut‐enriched Krüppel‐like factor gene during development and intestinal tumorigenesis

Ton-That, H., Kaestner, K. H., Shields, J. M., Mahatanankoon, C. S., & Yang, V. W. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01465-8 · Cited by 108

MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet β Cells

Fernández-Zapico, M. E., van Velkinburgh, J. C., Gutiérrez‐Aguilar, R., NEVE, B. P., Froguel, P., Urrutia, R. A., & Stein, R. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028852 · Cited by 108

Loss of Kruppel-Like Factor 4 Expression Contributes to Sp1 Overexpression and Human Gastric Cancer Development and Progression

Kanai, M., Wei, D., Li, Q., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1034 · Cited by 107

The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts

Wang, B., Haldar, S. M., Lu, Y., Ibrahim, O. A., Fisch, S., Gray, S., Leask, A., & Jain, M. K. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.05.005 · Cited by 107

Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination

DiFeo, A. V., Narla, G., Hirshfeld, J., Camacho‐Vanegas, O., Narla, J., Rose, S. L., Kalir, T., Yao, S., Levine, A. C., Birrer, M. J., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0054 · Cited by 107

KLF8 transcription factor participates in oncogenic transformation

Wang, X., & Zhao, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209796 · Cited by 106

An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation

Fernández-Zapico, M. E., Mladek, A. C., Ellenrieder, V., Folch‐Puy, E., Miller, L., & Urrutia, R. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg470 · Cited by 106

Ras Promotes Growth by Alternative Splicing-Mediated Inactivation of the KLF6 Tumor Suppressor in Hepatocellular Carcinoma

Yea, S., Narla, G., Zhao, X. Y., Garg, R., Kremer-Tal, S., Hod, E. A., Villanueva, A., Loke, J. C., Tarocchi, M., Akita, K., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.015 · Cited by 106

RFLAT-1

Song, A., Chen, Y.-F., Thamatrakoln, K., Storm, T. A., & Krensky, A. M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80010-2 · Cited by 105

Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1

Zheng, H. Q., Zhou, Z., Huang, J., Chaudhury, L., Dong, J. T., & Chen, C. (2009) · Oncogene · doi:10.1038/onc.2009.235 · Cited by 105

FKLF, a Novel Krüppel-Like Factor That Activates Human Embryonic and Fetal β-Like Globin Genes

Asano, H., Li, X. S., & Stamatoyannopoulos, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3571 · Cited by 105

Identification of the Imprinted KLF14 Transcription Factor Undergoing Human-Specific Accelerated Evolution

Parker-Katiraee, L., Carson, A. R., Yamada, T., Arnaúd, P., Feil, R., Abu-Amero, S. N., Moore, G. E., Kaneda, M., Perry, G. H., Stone, A. C., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030065 · Cited by 104

Human Mucin 1 Oncoprotein Represses Transcription of the p53 Tumor Suppressor Gene

Wei, X., Xu, H., & Kufe, D. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3063 · Cited by 103

Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity

Sommer, A., Hilfenhaus, S., Menkel, A. R., Kremmer, E., Seiser, C., Loidl, P., & Lüscher, B. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00183-7 · Cited by 102

Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene

Dang, D. T. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf400 · Cited by 101

KLF2 Transcription Factor Modulates Blood Vessel Maturation through Smooth Muscle Cell Migration

Wu, J., Bohanan, C. S., Neumann, J. C., & Lingrel, J. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707882200 · Cited by 100

Decreased expression of the gut‐enriched Krüppel‐like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients

Dang, D. T., Bachman, K. E., Mahatan, C. S., Dang, L. H., Giardiello, F. M., & Yang, V. W. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01727-0 · Cited by 100

Destabilization of Kruppel-Like Factor 4 Protein in Response to Serum Stimulation Involves the Ubiquitin-Proteasome Pathway

Chen, Z. Y., Wang, X., Zhou, Y., Offner, G. D., & Tseng, C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2059 · Cited by 100

Krüppel ‐like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells

Yang, Y., Goldstein, B. G., Nakagawa, H., & Katz, J. P. (2006) · The FASEB Journal · doi:10.1096/fj.06-6694com · Cited by 100

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivo

Basu, P., Morris, P. E., Haar, J. L., Wani, M. A., Lingrel, J. B., Gaensler, K. M. L., & Lloyd, J. A. (2005) · Blood · doi:10.1182/blood-2005-02-0674 · Cited by 99

Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2

Pilon, A. M., Arcasoy, M. O., Dressman, H. K., Vayda, S. E., Maksimova, Y. D., Sangerman, J., Gallagher, P. G., & Bodine, D. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01087-08 · Cited by 99

Do LCRs Open Chromatin Domains?

Higgs, D. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81761-4 · Cited by 98

Haploinsufficiency of Krüppel-Like Factor 4 Promotes Adenomatous Polyposis Coli–Dependent Intestinal Tumorigenesis

Ghaleb, A. M., McConnell, B. B., Nandan, M. O., Katz, J. P., Kaestner, K. H., & Yang, V. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1302 · Cited by 98

Transcriptional Activation of the Zinc Finger Transcription Factor BTEB2 Gene by Egr-1 Through Mitogen-Activated Protein Kinase Pathways in Vascular Smooth Muscle Cells

Kawai‐Kowase, K., Kurabayashi, M., Hoshino, Y., Ohyama, Y., & Nagai, R. (1999) · Circulation Research · doi:10.1161/01.res.85.9.787 · Cited by 98

Subfertility, Uterine Hypoplasia, and Partial Progesterone Resistance in Mice Lacking the Krüppel-like Factor 9/Basic Transcription Element-binding Protein-1 (Bteb1) Gene

Simmen, R. C. M., Eason, R. R., McQuown, J. R., Linz, A. L., Kang, T. J., Chatman, L., Till, S. R., Fujii‐Kuriyama, Y., Simmen, F. A., & Oh, S. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403139200 · Cited by 97

Transcriptional regulation of RANTES expression in T lymphocytes

Song, A., Nikolcheva, T., & Krensky, A. M. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17610.x · Cited by 97

Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells

Zhao, Y., Hamza, M. S., Leong, H. S., Lim, C.-B., Pan, Y.-F., Cheung, E. C. W., Soo, K.-C., & Iyer, N. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210625 · Cited by 96

Kruppel-like Factor KLF10 Targets Transforming Growth Factor-β1 to Regulate CD4+CD25− T Cells and T Regulatory Cells

Cao, Z., Wara, A. K., Icli, B., Sun, X., Packard, R. R. S., Esen, F., Stapleton, C. J., Subramaniam, M., Kretschmer, K., Apostolou, I., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000059 · Cited by 96

Genetic alterations of the KLF6 gene in gastric cancer

Cho, Y. G., Kim, C. J., Park, C. H., Yang, Y. M., Kim, S. Y., Nam, S. W., Lee, S. H., Yoo, N. J., Lee, J. Y., & Park, W. S. (2005) · Oncogene · doi:10.1038/sj.onc.1208670 · Cited by 96

Eloquent silence: developmental functions of Class I histone deacetylases

Cunliffe, V. T. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.10.001 · Cited by 96

Identification of KLF13 and KLF14 (SP6), Novel Members of the SP/XKLF Transcription Factor Family

Scohy, S., Gabant, P., Reeth, T. V., Hertveldt, V., Drèze, P.-L., Vooren, P. V., Rivière, M., Szpirer, J., & Szpirer, C. (2000) · Genomics · doi:10.1006/geno.2000.6362 · Cited by 96

Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells

Chanchevalap, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl014 · Cited by 96

SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5

Du, J. X., Bialkowska, A. B., McConnell, B. B., & Yang, V. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803612200 · Cited by 96

Krüppel-like family of transcription factors: an emerging new frontier in fat biology

Brey, C. W., Nelder, M. P., Hailemariam, T. K., Gaugler, R. R., & Hashmi, S. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.622 · Cited by 96

The Kruppel‐like transcription factor KLF13 is a novel regulator of heart development

Lavallée, G., Andelfinger, G., Nadeau, M., Lefèbvre, C., Nemer, G. M., Horb, M. E., & Nemer, M. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601379 · Cited by 95

Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes

Kanazawa, A., Kawamura, Y., Sekine, A., Iida, A., Tsunoda, T., Kashiwagi, A., Tanaka, Y., Babazono, T., Matsuda, M., Kawai, K., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1797-0 · Cited by 95

Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation by Inhibiting KLF5

Fujiu, K., Manabe, I., Ishihara, A., Oishi, Y., Iwata, H., Nishimura, G., Shindo, T., Maemura, K., Kagechika, H., Shudo, K., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000190613.22565.13 · Cited by 95

The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media

Adelman, C. A., Chattopadhyay, S., & Bieker, J. J. (2002) · Development · doi:10.1242/dev.129.2.539 · Cited by 94

The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.

Nandan, M. O., & Yang, V. W. (2009) · PubMed · doi:10.14670/hh-24.1343 · Cited by 93

Transcriptional Regulation of Tissue-Specific Genes by the ERK5 Mitogen-Activated Protein Kinase

Sohn, S. J., Li, D., Lee, L. K., & Winoto, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8553-8566.2005 · Cited by 93

A Nanoparticle System Specifically Designed to Deliver Short Interfering RNA Inhibits Tumor Growth In vivo

Yagi, N., Manabe, I., Tottori, T., Ishihara, A., Ogata, F., Kim, J. H., Nishimura, S., Fujiu, K., Oishi, Y., Itaka, K., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3945 · Cited by 92

Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation

Kremer-Tal, S., Narla, G., Chen, Y., Hod, E. A., DiFeo, A. V., Yea, S., Lee, J., Schwartz, M., Thung, S. N., Fiel, M. I., et al. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.10.012 · Cited by 91

Transcriptional regulation of the AP-2α promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor

Imhof, A., Schuierer, M., Werner, O., Moser, M., Roth, C., Bauer, R., & Buettner, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.194 · Cited by 90

Krüppel‐like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras‐mediated transformation

Nandan, M. O., Chanchevalap, S., Dalton, W. B., & Yang, V. W. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.053 · Cited by 90

Krüppel-like factor 4 prevents centrosome amplification following γ-irradiation-induced DNA damage

Yoon, H. S., Ghaleb, A. M., Nandan, M. O., Hisamuddin, I. M., Dalton, W. B., & Yang, V. W. (2005) · Oncogene · doi:10.1038/sj.onc.1208576 · Cited by 88

Tissue, cell type, and breast cancer stage-specific expression of a TGF-β inducible early transcription factor gene

Subramaniam, M., Hefferan, T. E., Tau, K. R., Péus, D., Pittelkow, M. R., Jalal, S. M., Riggs, B. L., Roche, P. C., & Spelsberg, T. C. (1998) · Journal of Cellular Biochemistry · Cited by 87

Role for SUMO Modification in Facilitating Transcriptional Repression by BKLF

Perdomo, J., Verger, A., Turner, J. J. O., & Crossley, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1549-1559.2005 · Cited by 87

KLF11 mediates a critical mechanism in TGF-β signaling that is inactivated by Erk-MAPK in pancreatic cancer cells

Ellenrieder, V., Buck, A., Harth, A. J., Jungert, K., Buchholz, M., Adler, G., Urrutia, R. A., & Gress, T. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.018 · Cited by 86

Down-Regulation of Laminin-5 in Breast Carcinoma Cells

Martin, K. J., Kwan, C., Nagasaki, K., Zhang, X., O’Hare, M. J., Kaelin, C. M., Burgeson, R. E., Pardee, A. B., & Sager, R. (1998) · Molecular Medicine · doi:10.1007/bf03401760 · Cited by 85

All‐trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Krüppel‐like factor 5

Chanchevalap, S., Nandan, M. O., Merlin, D., & Yang, V. W. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.079 · Cited by 84

Transactivation of the Human Keratin 4 and Epstein-Barr Virus ED-L2 Promoters by Gut-enriched Krüppel-like Factor

Jenkins, T. D., Opitz, O. G., Okano, J., & Rustgi, A. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10747 · Cited by 84

Krüppel-Like Factor 9 Is a Negative Regulator of Ligand-Dependent Estrogen Receptor α Signaling in Ishikawa Endometrial Adenocarcinoma Cells

Velarde, M. C., Zeng, Z., McQuown, J. R., Simmen, F. A., & Simmen, R. C. M. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0242 · Cited by 83

Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis

Chen, Y., Wu, C., Chang, C., Ma, C.-J., Li, M., & Chen, C. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.5.5768 · Cited by 83

Defective Megakaryopoiesis and Abnormal Erythroid Development inFli-1 Gene-Targeted Mice

Kawada, H., Ito, T., Pharr, P. N., Spyropoulos, D. D., Watson, D. K., & Ogawa, M. (2001) · International Journal of Hematology · doi:10.1007/bf02994008 · Cited by 83

Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice

Coghill, E., Eccleston, S., Fox, V., Cerruti, L., Brown, C., Cunningham, J. M., Jane, S. M., & Perkins, A. C. (2001) · Blood · doi:10.1182/blood.v97.6.1861 · Cited by 82

Developmental expression of the mouse gene coding for the kr�ppel-like transcription factor KLF5

Ohnishi, S., Laub, F., Matsumoto, N., Asaka, M., Ramirez, F., Yoshida, T., & Terada, M. (2000) · Developmental Dynamics · Cited by 82

Lysophosphatidic Acid Facilitates Proliferation of Colon Cancer Cells via Induction of Krüppel-like Factor 5

Zhang, H., Bialkowska, A. B., Rusovici, R., Chanchevalap, S., Shim, H., Katz, J. P., Yang, V. W., & Yun, C. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700702200 · Cited by 82

Estrogen Regulation of a Transforming Growth Factor- Inducible Early Gene That Inhibits Deoxyribonucleic Acid Synthesis in Human Osteoblasts

Tau, K. R., Hefferan, T. E., Waters, K. M., Robinson, J. A., Subramaniam, M., Riggs, B. L., & Spelsberg, T. C. (1998) · Endocrinology · doi:10.1210/endo.139.3.5830 · Cited by 82

KLF5 Promotes Breast Cell Survival Partially through Fibroblast Growth Factor-binding Protein 1-pERK-mediated Dual Specificity MKP-1 Protein Phosphorylation and Stabilization

Liu, R., Zheng, H., Zhou, Z., Dong, J., & Chen, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808919200 · Cited by 82

Haploinsufficiency of Krüppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the ApcMin Mutation in the Intestine

McConnell, B. B., Bialkowska, A. B., Nandan, M. O., Ghaleb, A. M., Gordon, F. J., & Yang, V. W. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4402 · Cited by 82

A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2

Yamamoto, J., Ikeda, Y., Iguchi, H., Fujino, T., Tanaka, T., Asaba, H., Iwasaki, S., Ioka, R. X., Kaneko, I. W., Magoori, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312079200 · Cited by 81

TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth

Cook, T. A., & Urrutia, R. A. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.4.g513 · Cited by 81

KLF4 is a FOXO target gene that suppresses B cell proliferation

Yusuf, I., Kharas, M. G., Chen, J., Peralta, R. Q., Maruniak, A., Sareen, P., Yang, V. W., Kaestner, K. H., & Fruman, D. A. (2008) · International Immunology · doi:10.1093/intimm/dxn024 · Cited by 80

Sumoylation of EKLF Promotes Transcriptional Repression and Is Involved in Inhibition of Megakaryopoiesis

Siatecka, M., Li, X., & Bieker, J. J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00589-07 · Cited by 80

Sumoylation Delimits KLF8 Transcriptional Activity Associated with the Cell Cycle Regulation

Wei, H., Wang, X., Gan, B., Urvalek, A. M., Melkoumian, Z. K., Guan, J., & Zhao, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513135200 · Cited by 79

Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function

Zhang, Z., & Teng, C. T. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg310 · Cited by 79

Fluid shear stress induces endothelial KLF2 gene expression through a defined promoter region

Huddleson, J. P., Srinivasan, S. V., Ahmad, N., & Lingrel, J. B. (2004) · Biological Chemistry · doi:10.1515/bc.2004.088 · Cited by 78

WWP1-dependent ubiquitination and degradation of the lung Krüppel-like factor, KLF2

Zhang, X., Srinivasan, S. V., & Lingrel, J. B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.033 · Cited by 78

Disruption of an SP2/KLF6 Repression Complex by SHP Is Required for Farnesoid X Receptor-induced Endothelial Cell Migration

Das, A., Fernández-Zapico, M. E., Cao, S., Yao, J. Z., Fiorucci, S., Hebbel, R. P., Urrutia, R. A., & Shah, V. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607720200 · Cited by 78

In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma

Narla, G., Kremer-Tal, S., Matsumoto, N., Zhao, X., Yao, S., Kelley, K., Tarocchi, M., & Friedman, S. L. (2007) · Oncogene · doi:10.1038/sj.onc.1210223 · Cited by 77

The Krüppel‐like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact

Okano, J., Opitz, O. G., Nakagawa, H., Jenkins, T. D., Friedman, S. L., & Rustgi, A. K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01468-x · Cited by 77

Acetylation of KLF5 Alters the Assembly of p15 Transcription Factors in Transforming Growth Factor-β-mediated Induction in Epithelial Cells

Guo, P., Zhao, K.-W., Dong, X., Sun, X., & Dong, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.007096 · Cited by 77

Krüppel-like Factor 5 Shows Proliferation-specific Roles in Vascular Remodeling, Direct Stimulation of Cell Growth, and Inhibition of Apoptosis

Suzuki, T., Sawaki, D., Aizawa, K., Munemasa, Y., Matsumura, T., Ishida, J., & Nagai, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806230200 · Cited by 77

KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia

Huang, C. C., Liu, Z., Li, X., Bailey, S. K., Nail, C. D., Foster, K. W., Frost, A. R., Ruppert, J. M., & Lobo-Ruppert, S. M. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.12.2355 · Cited by 77

Transcriptional regulation of Smad2 is required for enhancement of TGFβ/Smad signaling by TGFβ inducible early gene

Johnsen, S. A., Subramaniam, M., Katagiri, T., Janknecht, R., & Spelsberg, T. C. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10299 · Cited by 77

Unanticipated Repression Function Linked to Erythroid Krüppel-Like Factor

Chen, X., & Bieker, J. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.3118-3125.2001 · Cited by 77

Methylation Status of Genes Upregulated by Demethylating Agent 5-aza-2′-Deoxycytidine in Hepatocellular Carcinoma

Hirasawa, Y., Arai, M., Imazeki, F., Tada, M., Mikata, R., Fukai, K., Miyazaki, M., Ochiai, T., Saisho, H., & Yokosuka, O. (2006) · Oncology · doi:10.1159/000100475 · Cited by 76

Basic Residues within the Kruppel Zinc Finger DNA Binding Domains Are the Critical Nuclear Localization Determinants of EKLF/KLF-1

Pandya, K., & Townes, T. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200866200 · Cited by 76

Pro-proliferative Factor KLF5 Becomes Anti-proliferative in Epithelial Homeostasis upon Signaling-mediated Modification

Guo, P., Dong, X., Zhang, X., Zhao, K., Sun, X., Li, Q., & Dong, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806270200 · Cited by 76

15‐hydroxy‐eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator‐activated receptor gamma‐dependent pathway

Chen, G. G., Xu, H., Lee, J. F. Y., Subramaniam, M., Leung, K. L., Wang, S. H., Chan, U. P. F., & Spelsberg, T. C. (2003) · International Journal of Cancer · doi:10.1002/ijc.11447 · Cited by 76

A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes

Rozenblum, E., Vahteristo, P., Sandberg, T., Bergþorsson, J. Þ., Syrjäkoski, K., Weaver, D., Haraldsson, K., Johannsdottir, H., Vehmanen, P., Nigam, S., et al. (2001) · Human Genetics · doi:10.1007/s00439-001-0646-6 · Cited by 75

Multiple Proteins Binding to a GATA-E Box-GATA Motif Regulate the Erythroid Krüppel-like Factor (EKLF) Gene

Anderson, K. P., Crable, S. C., & Lingrel, J. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14347 · Cited by 75

The Deacetylase HDAC1 Negatively Regulates the Cardiovascular Transcription Factor Krüppel-like Factor 5 through Direct Interaction

Matsumura, T., Suzuki, T., Aizawa, K., Munemasa, Y., Muto, S., Horikoshi, M., & Nagai, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410578200 · Cited by 75

Induction of Krüppel-Like Factor 5 Expression by Androgens Results in Increased CXCR4-Dependent Migration of Prostate Cancer Cellsin Vitro

Frigo, D. E., Sherk, A. B., Wittmann, B. M., Norris, J. D., Wang, Q., Joseph, J. D., Toner, A. P., Brown, M. A., & McDonnell, D. P. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0010 · Cited by 75

Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)

Mahatan, C. S. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.23.4562 · Cited by 74

The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression

Simmen, F. A., Su, Y., Xiao, R., Zeng, Z., & Simmen, R. C. M. (2008) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-6-41 · Cited by 74

Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression

Methe, H., Balcells, M., Alegret, M. D. C., Santacana, M., Molins, B., Hamik, A., Jain, M. K., & Edelman, E. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00403.2006 · Cited by 74

Role of Krüppel-like factor 15 in PEPCK gene expression in the liver

Teshigawara, K., Ogawa, W., Mori, T., Matsuki, Y., Watanabe, E., Hiramatsu, R., Inoue, H., Miyake, K., Sakaue, H., & Kasuga, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.096 · Cited by 72

Dopamine receptor regulating factor, DRRF: A zinc finger transcription factor

Hwang, C. K., D’Souza, U. M., Eisch, A. J., Yajima, S., Lammers, C., Yang, Y., Lee, S.-H., Kim, Y.-M., Nestler, E. J., & Mouradian, M. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121635798 · Cited by 71

Stage-Specific Repression by the EKLF Transcriptional Activator

Chen, X., & Bieker, J. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10416-10424.2004 · Cited by 71

Up-Regulation of Krüppel-Like Factor 5 in Pancreatic Cancer Is Promoted by Interleukin-1β Signaling and Hypoxia-Inducible Factor-1α

Mori, A., Moser, C., Lang, S. A., Hackl, C., Gottfried, E., Kreutz, M. P., Schlitt, H. J., Geissler, E. K., & Stoeltzing, O. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0525 · Cited by 71

Activation of KLF8 Transcription by Focal Adhesion Kinase in Human Ovarian Epithelial and Cancer Cells

Wang, X., Urvalek, A. M., Liu, J., & Zhao, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709300200 · Cited by 70

Balancing Contractility and Energy Production: The Role of Myocyte Enhancer Factor 2 (MEF2) in Cardiac Hypertrophy

Czubryt, M. P., & Olson Eric, N. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.105 · Cited by 70

Lung Cancers Detected by Screening with Spiral Computed Tomography Have a Malignant Phenotype when Analyzed by cDNA Microarray

Bianchi, F., Hu, J., Pelosi, G., Cirincione, R., Ferguson, M. L., Ratcliffe, C., Fiore, P. P. D., Gatter, K. C., Pezzella, F., & Pastorino, U. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0619 · Cited by 70

A Functional Role for KLF6-SV1 in Lung Adenocarcinoma Prognosis and Chemotherapy Response

DiFeo, A. V., Feld, L. D., Rodríguez, E., Wang, C., Beer, D. G., Martignetti, J. A., & Narla, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2604 · Cited by 70

Regulation of Erythroid Krüppel-like Factor (EKLF) Transcriptional Activity by Phosphorylation of a Protein Kinase Casein Kinase II Site within Its Interaction Domain

Ouyang, L., Chen, X., & Bieker, J. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23019 · Cited by 68

KLF4 suppresses transformation of pre-B cells by ABL oncogenes

Kharas, M. G., Yusuf, I., Scarfone, V. M., Yang, V. W., Segre, J. A., Huettner, C. S., & Fruman, D. A. (2006) · Blood · doi:10.1182/blood-2006-03-011106 · Cited by 68

Functional Analysis of Basic Transcription Element Binding Protein by Gene Targeting Technology

Morita, M., Kobayashi, A., Yamashita, T., Shimanuki, T., Nakajima, O., Takahashi, S., Ikegami, S., Inokuchi, K., Yamashita, K. H., Yamamoto, M. P., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2489-2500.2003 · Cited by 68

Kruppel-like Factor 4 is Required for the Expression of Vascular Smooth Muscle Cell Differentiation Marker Genes Induced by All-Trans Retinoic Acid

Wang, C., Han, M., Zhao, X., & Wen, J. (2008) · The Journal of Biochemistry · doi:10.1093/jb/mvn068 · Cited by 67

Dysregulation of systemic iron metabolism in alcoholic liver diseases

Kohgo, Y., Ohtake, T., Ikuta, K., Suzuki, Y., Torimoto, Y., & Kato, J. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05290.x · Cited by 66

KLF11-mediated Repression Antagonizes Sp1/Sterol-responsive Element-binding protein-induced Transcriptional Activation of Caveolin-1 in Response to Cholesterol Signaling

Cao, S., Fernández-Zapico, M. E., Jin, D., Puri, V., Cook, T. A., Lerman, L. O., Zhu, X.-Y., Urrutia, R. A., & Shah, V. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407941200 · Cited by 66

KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis

Sirach, E., Bureau, C., Péron, J., Pradayrol, L., Vinel, J. P., Buscail, L., & Cordelier, P. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402114 · Cited by 66

A functional screen for Krüppel-like factors that regulate the human γ-globin gene through the CACCC promoter element

Zhang, P., Basu, P., Redmond, L. C., Morris, P. E., Rupon, J. W., Ginder, G. D., & Lloyd, J. A. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.009 · Cited by 65

A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes

Nikolcheva, T., Pyronnet, S., Chou, S.-Y., Sonenberg, N., Song, A., Clayberger, C., & Krensky, A. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15336 · Cited by 65

Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element

Kulozik, A. E., Bellan-Koch, A., Bail, S., KOHNE, E., & Kleihauer, E. (1991) · Blood · doi:10.1182/blood.v77.9.2054.bloodjournal7792054 · Cited by 64

Cloning and Characterization of Murine Glial Cell-Derived Neurotrophic Factor Inducible Transcription Factor (MGIF)

Yajima, S., Lammers, C., Lee, S.-H., Hara, Y., Mizuno, K., & Mouradian, M. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-22-08657.1997 · Cited by 64

TGFβ inducible early gene-1 knockout mice display defects in bone strength and microarchitecture

Bensamoun, S. F., Hawse, J. R., Subramaniam, M., Ilharreborde, B., Bassillais, A., Benhamou, C. L., Fraser, D. G., Oursler, M. J., Amadio, P. C., An, K., et al. (2006) · Bone · doi:10.1016/j.bone.2006.05.021 · Cited by 64

Gut-Enriched Krüppel-Like Factor Interaction with Smad3 Inhibits Myofibroblast Differentiation

Hu, B., Wu, Z., Liu, T., Ullenbruch, M. R., Jin, H., & Phan, S. H. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0043oc · Cited by 64

EKLF and KLF2 have compensatory roles in embryonic β-globin gene expression and primitive erythropoiesis

Basu, P., Lung, T. K., Lemsaddek, W., Sargent, T. G., Williams, D. C., Basu, M., Redmond, L. C., Lingrel, J. B., Haar, J. L., & Lloyd, J. A. (2007) · Blood · doi:10.1182/blood-2006-11-057307 · Cited by 64

Bone Morphogenetic Protein 2 Opposes Shh-mediated Proliferation in Cerebellar Granule Cells through a TIEG-1-based Regulation of Nmyc

Álvarez-Rodríguez, R., Barzi, M., Berenguer, J., & Pons, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705414200 · Cited by 64

Direct Interaction of the Krüppel-like Family (KLF) Member, BTEB1, and PR Mediates Progesterone-Responsive Gene Expression in Endometrial Epithelial Cells

Zhang, D., Zhang, X., Michel, F. J., et al. (2002) · Endocrinology · doi:10.1210/endo.143.1.8590 · Cited by 63

TGFβ inducible early gene‐1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway

Rajamannan, N. M., Subramaniam, M., Abraham, T. P., Vasile, V. C., Ackerman, M. J., Monroe, D. G., Chew, T., & Spelsberg, T. C. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21049 · Cited by 62

Identification of LKLF-regulated genes in quiescent CD4 T lymphocytes

Haaland, R. E., Yu, W., & Rice, A. P. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.09.012 · Cited by 61

Regulation of Krüppel-like Factor 6 Tumor Suppressor Activity by Acetylation

Li, D., Yea, S., Dolios, G., Martignetti, J. A., Narla, G., Wang, R., Walsh, M. J., & Friedman, S. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1040 · Cited by 61

Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells

Waßmann, S., Wassmann, K., Jung, A., Velten, M., Knuefermann, P., Petoumenos, V., Becher, U. M., Werner, C. M., Mueller, C. F. H., & Nickenig, G. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.06.001 · Cited by 61

Functional role of the KLF6 tumour suppressor gene in gastric cancer

Sangodkar, J., Shi, J., DiFeo, A. V., Schwartz, R., Bromberg, R. J., Choudhri, A., McClinch, K., Hatami, R., Scheer, E., Kremer-Tal, S., et al. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.11.009 · Cited by 61

TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer.

Ellenrieder, V. (2008) · PubMed · Cited by 61

Kruppel-Like Transcription Factor 13 Regulates T Lymphocyte Survival In Vivo

Zhou, M., McPherson, L. A., Feng, D., Song, A., Dong, C., Lyu, S., Zhou, L., Shi, X., Ahn, Y.-T., Wang, D., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5496 · Cited by 60

Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men

Yerges, L. M., Klei, L., Cauley, J. A., Roeder, K., Kammerer, C. M., Ensrud, K. E., Nestlerode, C. S., Lewis, C. E., Lang, T., Barrett-Connor, E. L., et al. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090729 · Cited by 60

Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors

Ivanov, S. V., Ivanova, A. V., Salnikow, K., Timofeeva, O. A., Subramaniam, M., & Lerman, M. I. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.066 · Cited by 59

Functional Domains and DNA-binding Sequences of RFLAT-1/KLF13, a Krüppel-like Transcription Factor of Activated T Lymphocytes

Song, A., Patel, A., Thamatrakoln, K., Liu, C., Feng, D., Clayberger, C., & Krensky, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204278200 · Cited by 59

Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis

Beckers, J., Herrmann, F., Rieger, S., Drobyshev, A. L., Horsch, M., de Angelis, M. H., & Seliger, B. (2004) · International Journal of Cancer · doi:10.1002/ijc.20798 · Cited by 59

Induction of AP-2α Expression by Adenoviral Infection Involves Inactivation of the AP-2rep Transcriptional Corepressor CtBP1

Schuierer, M. M., Hilger-Eversheim, K., Dobner, T., Bosserhoff, A., Moser, M., Turner, J. J. O., Crossley, M., & Buettner, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100070200 · Cited by 58

Role for Krüppel-Like Factor 4 in Determining the Outcome of p53 Response to DNA Damage

Zhou, Q., Yuan, H., Zhan, Q., Shen, Y., & Liu, Z. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1345 · Cited by 58

The Tumor Suppressor KLF11 Mediates a Novel Mechanism in Transforming Growth Factor β–Induced Growth Inhibition That Is Inactivated in Pancreatic Cancer

Buck, A., Buchholz, M., Wagner, M., Adler, G., Gress, T. M., & Ellenrieder, V. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0081 · Cited by 58

Angiotensin II Stimulates KLF5 Phosphorylation and its Interaction with c-Jun Leading to Suppression of p21 Expression in Vascular Smooth Muscle Cells

He, M., Han, M., Zheng, B., Shu, Y.-N., & Wen, J. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp115 · Cited by 57

Krüppel-like Factor 5 Causes Cartilage Degradation through Transactivation of Matrix Metalloproteinase 9

Shinoda, Y., Ogata, N., Higashikawa, A., Manabe, I., Shindo, T., Yamada, T., Kugimiya, F., Ikeda, T., Kawamura, N., Kawasaki, Y., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709857200 · Cited by 57

The pathobiology of Krüppel-like factors in colorectal cancer

Ghaleb, A. M., & Yang, V. W. (2008) · Current Colorectal Cancer Reports · doi:10.1007/s11888-008-0011-4 · Cited by 57

Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment

Lohmann, F., & Bieker, J. J. (2008) · Development · doi:10.1242/dev.018200 · Cited by 57

Differential Gene Expression of TGFβ Inducible Early Gene (TIEG), Smad7, Smad2 and Bard1 in Normal and Malignant Breast Tissue

Reinholz, M. M., An, M., Johnsen, S. A., Subramaniam, M., Suman, V. J., Ingle, J. N., Roche, P. C., & Spelsberg, T. C. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000032926.74216.7d · Cited by 56

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined Apc Min and KRASV 12mutations

Nandan, M. O., Ghaleb, A. M., McConnell, B. B., Patel, N. V., Robine, S., & Yang, V. W. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-63 · Cited by 56

Fetal expression of a human Aγ globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

Perkins, A. C., Peterson, K. R., Stamatoyannopoulos, G., Witkowska, H. E., & Orkin, S. H. (2000) · Blood · doi:10.1182/blood.v95.5.1827.004k10_1827_1833 · Cited by 55

Krüppel-like Factor 5 Controls Keratinocyte Migration via the Integrin-linked Kinase

Yang, Y., Tétreault, M.-P., Yermolina, Y. A., Goldstein, B. G., & Katz, J. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801384200 · Cited by 55

Kruppel-Like Factor 4 Regulates B Cell Number and Activation-Induced B Cell Proliferation

Klaewsongkram, J., Yang, Y., Golech, S., Katz, J. P., Kaestner, K. H., & Weng, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4679 · Cited by 54

Early genes induced in hepatic stellate cells during wound healing

Lalazar, A., Wong, L., Yamasaki, G., & Friedman, S. L. (1997) · Gene · doi:10.1016/s0378-1119(97)00159-5 · Cited by 53

Krüppel-Like Factor 4 Is Transactivated by Butyrate in Colon Cancer Cells

Chen, Z. Y., Rex, S., & Tseng, C. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.792 · Cited by 52

Opposing Effects of KLF5 on the Transcription of MYC in Epithelial Proliferation in the Context of Transforming Growth Factor β

Guo, P., Dong, X., Zhao, K., Sun, X., Li, Q., & Dong, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.036160 · Cited by 52

Kruppel-like Factor 4 Regulates Laminin α3A Expression in Mammary Epithelial Cells

Miller, K. A., Eklund, E. A., Peddinghaus, M. L., Cao, Z., Fernandes, N., Turk, P. W., Thimmapaya, B., & Weitzman, S. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108130200 · Cited by 52

Krüppel-like Factor 4 Inhibits Proliferation by Platelet-derived Growth Factor Receptor β-mediated, Not by Retinoic Acid Receptor α-mediated, Phosphatidylinositol 3-Kinase and ERK Signaling in Vascular Smooth Muscle Cells

Zheng, B., Han, M., Bernier, M., Zhang, X., Meng, F., Miao, S., He, M., Zhao, X.-M., & Wen, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026989 · Cited by 51

2-Cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor in colon and pancreatic cancer cells

Chintharlapalli, S. R., Papineni, S., Liu, S., Jutooru, I., Chadalapaka, G., Cho, S. D., Murthy, R. S., You, Y., & Safe, S. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm189 · Cited by 51

15-Deoxy-Δ12,14 Prostaglandin J2 Up-Regulates Krüppel-Like Factor 4 Expression Independently of Peroxisome Proliferator-Activated Receptor γ by Activating the Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signal Transduction Pathway in HT-29 Colon Cancer Cells

Chen, Z. Y., & Tseng, C. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.014944 · Cited by 50

TIEG-null mice display an osteopenic gender-specific phenotype

Hawse, J. R., Iwaniec, U. T., Bensamoun, S. F., Monroe, D. G., Peters, K. D., Ilharreborde, B., Rajamannan, N. M., Oursler, M. J., Turner, R. T., Spelsberg, T. C., et al. (2008) · Bone · doi:10.1016/j.bone.2008.02.004 · Cited by 50

A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes

Nikolcheva, T., Pyronnet, S., Chou, S.-Y., Sonenberg, N., Song, A., Clayberger, C., & Krensky, A. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215336 · Cited by 50

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression

Anderson, K. P., Crable, S. C., & Lingrel, J. B. (2000) · Blood · doi:10.1182/blood.v95.5.1652.005k23_1652_1655 · Cited by 49

Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Krüppel-like factor 9

Simmen, F. A., Xiao, R., Velarde, M. C., Nicholson, R. D., Bowman, M. T., Fujii‐Kuriyama, Y., Oh, S. P., & Simmen, R. C. M. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00013.2007 · Cited by 49

PIAS1 Activates the Expression of Smooth Muscle Cell Differentiation Marker Genes by Interacting with Serum Response Factor and Class I Basic Helix-Loop-Helix Proteins

Kawai‐Kowase, K., Kumar, M. S., Hoofnagle, M. H., Yoshida, T., & Owens, G. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8009-8023.2005 · Cited by 49

Krüppel-like factor 4 (KLF4): What we currently know

Ghaleb, A. M., & Yang, V. W. (2017) · Gene · doi:10.1016/j.gene.2017.02.025 · Cited by 523

A single-cell atlas of chromatin accessibility in the human genome

Zhang, K., Hocker, J. D., Miller, M., Hou, X., Chiou, J., Poirion, O. B., Qiu, Y., Li, Y. E., Gaulton, K. J., Wang, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.024 · Cited by 502

Transcriptional Control of Dendritic Cell Development

Murphy, T. L., Grajales-Reyes, G. E., Wu, X., Tussiwand, R., Briseño, C. G., Iwata, A., Kretzer, N. M., Durai, V., & Murphy, K. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120204 · Cited by 489

Krüppel-like factors in cancer

Tetreault, M.-P., Yang, Y., & Katz, J. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3582 · Cited by 398

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Bis, J. C., Jian, X., Kunkle, B. W., Chen, Y., Hamilton-Nelson, K. L., Bush, W. S., Salerno, W. J., Lancour, D., Ma, Y., Renton, A. E., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0112-7 · Cited by 248