Mammalian Krüppel-Like Factors in Health and Diseases

Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes

Zobel, D. P., Andreasen, C. H., Burgdorf, K. S., Galijatovic, E. A. A., Sandbæk, A., Lauritzen, T., Borch‐Johnsen, K., Jørgensen, T., Maeda, S., Nakamura, Y., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0688 · Cited by 49

Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells

Zhang, X., Zheng, B., Han, M., Miao, S., & Wen, J. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.03.016 · Cited by 47

Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells

Jiang, L., Chen, Y., Chan, C., Wang, X., Lin, L., He, M., Lin, M. C. M., Yew, D. T. W., Sung, J. J. �., Li, J., et al. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.09.017 · Cited by 47

Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling

Mack, P. J., Zhang, Y., Chung, S. H., Vickerman, V., Kamm, R. D., & García‐Cardeña, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804524200 · Cited by 47

Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable

Hagos, E. G., Ghaleb, A. M., Dalton, W. B., Bialkowska, A. B., & Yang, V. W. (2009) · Oncogene · doi:10.1038/onc.2008.465 · Cited by 47

Krüppel-like Factors Regulate the Lama1 Gene Encoding the Laminin α1 Chain

Piccinni, S. A., Bolcato‐Bellemin, A., Klein, A., Yang, V. W., Kédinger, M., Simon-Assmann, P. M., & Lefèbvre, O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305804200 · Cited by 46

Krüppel-Like Factor 5 Mediates Transmissible Murine Colonic Hyperplasia Caused by Citrobacter rodentium Infection

McConnell, B. B., Klapproth, J. A., Sasaki, M., Nandan, M. O., & Yang, V. W. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.013 · Cited by 46

KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model

DiFeo, A. V., Huang, F., Sangodkar, J., Terzo, E., Leake, D., Narla, G., & Martignetti, J. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4282 · Cited by 46

Expression of Krüppel-like factor 5 in human gastric carcinomas

Kwak, M. K., Lee, H., Hur, K., Park, D. J., Lee, H. S., Kim, W. H., Lee, K. U., Choe, K. J., Guilford, P., & Yang, H. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0265-2 · Cited by 45

Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer

Hartel, M., Narla, G., Wente, M. N., Giese, N. A., Martignoni, M. E., Martignetti, J. A., Friess, H., & Friedman, S. L. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.06.030 · Cited by 45

KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations

Agell, L., Hernandez, S. F., de Muga, S., Lorente, J. A., Juanpere-Rodero, N., Esgueva, R., Serrano, S., Gelabert-Más, A., & Lloreta, J. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.145 · Cited by 45

All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells

Meng, F., Han, M., Zheng, B., Wang, C., Zhang, R., Zhang, X., & Wen, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.112 · Cited by 43

Genetic and epigenetic analysis of the KLF4 gene in gastric cancer

Cho, Y. G., Song, J. H., Kim, C. J., Nam, S. W., Yoo, N. J., Lee, J. Y., & Park, W. S. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_643.x · Cited by 43

A Shortened Life Span of EKLF−/− Adult Erythrocytes, Due to a Deficiency of β-Globin Chains, Is Ameliorated by Human γ-Globin Chains

Lim, S. K., Bieker, J. J., Lin, C., & Costantini, F. D. (1997) · Blood · doi:10.1182/blood.v90.3.1291 · Cited by 42

Expression of Concern: TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade

Jin, W., Di, G., Li, J., Chen, Y., Li, W., Wu, J., Cheng, T., Yao, M., & Shao, Z. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.07.008 · Cited by 42

Splenomegaly and Modified Erythropoiesis in KLF13–/– Mice

Gordon, A. R., Outram, S. V., Keramatipour, M., Goddard, C. A., Colledge, W. H., Metcalfe, J. C., Hager-Theodorides, A. L., Crompton, T., & Kemp, P. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709569200 · Cited by 42

Analysis of human prostate cancers and cell lines for mutations in the TP53 and KLF6 tumour suppressor genes

Mühlbauer, K.-R., Gröne, H., Ernst, T., Gröne, E. F., Tschada, R., Hergenhahn, M., & Hollstein, M. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601164 · Cited by 41

KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells

Lee, M., Moon, J., Park, S. W., Koh, Y.-K., Ahn, Y., & Kim, K. (2008) · Biochemical Journal · doi:10.1042/bj20080762 · Cited by 41

Transcriptional Profiling of the Cell Cycle Checkpoint Gene Krüppel-Like Factor 4 Reveals a Global Inhibitory Function in Macromolecular Biosynthesis

Whitney, E. M., Ghaleb, A. M., Chen, X., & YANG, A. V. W. (2006) · Gene Expression · doi:10.3727/000000006783991908 · Cited by 41

Endocardial cushion development and heart loop architecture in the trisomy 16 mouse

Webb, S., Anderson, R. H., & Brown, N. A. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199607)206:3<248::aid-aja3>3.0.co;2-i · Cited by 40

The Krüppel-Like Core Promoter Binding Protein Gene Is Primarily Expressed in Placenta During Mouse Development1

Slavin, D. A., Sapin, V., López-Díaz, F. J., Jacquemin, P., Koritschoner, N. P., Dastugue, B., Davidson, I., Chatton, B., & Bocco, J. L. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.6.1586 · Cited by 38

Dynamic Interplay of Transcriptional Machinery and Chromatin Regulates “Late” Expression of the Chemokine RANTES in T Lymphocytes

Ahn, Y.-T., Huang, B., McPherson, L. A., Clayberger, C., & Krensky, A. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01071-06 · Cited by 38

KLF5/BTEB2, A Krüppel-like Zinc-finger Type Transcription Factor, Mediates Both Smooth Muscle Cell Activation And Cardiac Hypertrophy

Nagai, R., Shindo, T., Manabe, I., Suzuki, T., & Kurabayashi, M. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9029-7_5 · Cited by 37

Protein Inhibitor of Activated STAT1 Interacts with and Up-regulates Activities of the Pro-proliferative Transcription Factor Krüppel-like Factor 5

Du, J. X., Yun, C. C., Bialkowska, A. B., & Yang, V. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603413200 · Cited by 37

Progesterone Receptor Transactivation of the Secretory Leukocyte Protease Inhibitor Gene in Ishikawa Endometrial Epithelial Cells Involves Recruitment of Krüppel-Like Factor 9/Basic Transcription Element Binding Protein-1

Velarde, M. C., Iruthayanathan, M., Eason, R. R., et al. (2005) · Endocrinology · doi:10.1210/en.2005-1419 · Cited by 37

Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma

Song, J., Kim, C. J., Cho, Y. G., Kim, S. Y., Nam, S. W., Lee, S. H., Yoo, N. J., Lee, J. Y., & Park, W. S. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04445.x · Cited by 36

Klf6 Is a Zinc Finger Protein Expressed in a Cell-Specific Manner during Kidney Development

Fischer, E. A., Verpont, M., Garrett‐Sinha, L. A., Ronco, P. M., & Rossert, J. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v124726 · Cited by 36

Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the β-Globin Locus

Sengupta, T., Chen, K., Milot, É., & Bieker, J. J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00919-08 · Cited by 36

Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers

Lièvre, A., Landi, B., Côté, J.-F., Veyrie, N., Zucman‐Rossi, J., Berger, A., & Laurent‐Puig, P. (2005) · Oncogene · doi:10.1038/sj.onc.1208867 · Cited by 35

Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening

Bialkowska, A. B., Du, Y., Fu, H., & Yang, V. W. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0767 · Cited by 35

KLF13 influences multiple stages of both B and T cell development

Outram, S. V., Gordon, A. R., Hager-Theodorides, A. L., Metcalfe, J. C., Crompton, T., & Kemp, P. R. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6234 · Cited by 35

Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition

Zhang, J., Yang, C. H., Brey, C. W., Rodriguez, M., Oksov, Y., Gaugler, R. R., Dickstein, E. R., Huang, C., & Hashmi, S. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.04.025 · Cited by 35

Interaction of PRP4 with Kruppel-Like Factor 13 Regulates CCL5 Transcription

Huang, B., Ahn, Y.-T., McPherson, L. A., Clayberger, C., & Krensky, A. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7081 · Cited by 34

Estrogen‐induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER‐positive breast cancer cells

Guo, P., Dong, X., Zhao, K., Sun, X., Li, Q., & Dong, J. (2009) · International Journal of Cancer · doi:10.1002/ijc.24696 · Cited by 33

Absence of KLF6 gene mutation in 71 hepatocellular carcinomas†

Boyault, S., Hérault, A., Balabaud, C. P., & Zucman‐Rossi, J. (2005) · Hepatology · doi:10.1002/hep.20588 · Cited by 33

Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling

Liu, Z., Teng, L., Bailey, S. K., Frost, A. R., Bland, K. I., LoBuglio, A. F., Ruppert, J. M., & Lobo-Ruppert, S. M. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.19.9440 · Cited by 32

Efficient Genetic Reprogramming of Unmodified Somatic Neural Progenitors Uncovers the Essential Requirement of Oct4 and Klf4

Stefano, B. D., Prigione, A., & Broccoli, V. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0180 · Cited by 31

KLF6 degradation after apoptotic DNA damage

Banck, M. S., Beaven, S. W., Narla, G., Walsh, M. J., Friedman, S. L., & Beutler, A. S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.10.077 · Cited by 31

EKLF/KLF1 is ubiquitinated in vivo and its stability is regulated by activation domain sequences through the 26S proteasome

Quadrini, K. J., & Bieker, J. J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.039 · Cited by 31

Differential role for IL-7 in inducing lung Kruppel-like factor (Kruppel-like factor 2) expression by naive versus activated T cells

Endrizzi, B. T. (2003) · International Immunology · doi:10.1093/intimm/dxg133 · Cited by 31

Chromatin Structure and Transcriptional Control Elements of the Erythroid Krüppel-like Factor (EKLF) Gene

Chen, X., Reitman, M. L., & Bieker, J. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25031 · Cited by 30

Regulatory elements of the EKLF gene that direct erythroid cell-specific expression during mammalian development

Li, X., Chen, X., Chang, Y., & Bieker, J. J. (2004) · Blood · doi:10.1182/blood-2003-09-3231 · Cited by 29

Increased expression of the Zn-finger transcription factor BTEB1 in human endometrial cells is correlated with distinct cell phenotype, gene expression patterns, and proliferative responsiveness to serum and TGF-β1

Zhang, X., Simmen, F. A., Michel, F. J., et al. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00536-6 · Cited by 29

Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter

Suda, S., Rai, T., Sohara, E., Sasaki, S., & Uchida, S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.138 · Cited by 28

The Biology of Krüppel-like Factors

Nagai, R., Friedman, S. L., & Kasuga, M. (2009) · Springer eBooks · doi:10.1007/978-4-431-87775-2 · Cited by 27

Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid

Jiang, W. G., Deng, W., Bailey, S. K., Nail, C. D., Frost, A. R., Brouillette, W. J., Muccio, D. D., Grubbs, C. J., Lobo-Ruppert, S. M., & Ruppert, J. M. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.3.7486 · Cited by 26

STAT1 Is Required for IFN-γ-Mediated Gut-Enriched Krüppel-like Factor Expression

Chen, Z. Y. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5633 · Cited by 24

Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma

Sangodkar, J., DiFeo, A. V., Feld, L. D., Bromberg, R. J., Schwartz, R., Huang, F., Terzo, E., Choudhri, A., & Narla, G. (2009) · Lung Cancer · doi:10.1016/j.lungcan.2009.02.014 · Cited by 23

Silencing of the transcription factor KLF6 by siRNA leads to cell cycle arrest and sensitizes cells to apoptosis induced by DNA damage

D’Astolfo, D. S., Gehrau, R. C., Bocco, J. L., & Koritschoner, N. P. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402299 · Cited by 23

Absence of KLF6 gene mutations in human astrocytic tumors and cell lines

Koivisto, P. A., Zhang, X., Sallinen, S., Sallinen, P. K., Helin, H. J., Dong, J., Meir, E. G. V., Haapasalo, H. K., & Hyytinen, E. (2004) · International Journal of Cancer · doi:10.1002/ijc.20301 · Cited by 21

Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: Role of TGFβ/BMP‐6 and TIEG1 in chemotherapy escape

Døsen, G., Munthe, E., Nygren, M. K., Stubberud, H., Hystad, M. E., & Rian, E. (2008) · International Journal of Cancer · doi:10.1002/ijc.23833 · Cited by 20

Nitric oxide-mediated upregulation of the TGF-β-inducible early response gene-1 (TIEG1) in human fibroblasts by mRNA stabilization independent of TGF-β

Mitsumoto, M., Mitsumoto, A., & Demple, B. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00211-9 · Cited by 19

The association of genetic variants in Krüppel‐like factor 11 and Type 2 diabetes in the Japanese population

Tanahashi, T., Shinohara, K., Keshavarz, P., Yamaguchi, Y., Miyawaki, K., Kunika, K., Moritani, M., Nakamura, N., Yoshikawa, T., Shiota, H., et al. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02315.x · Cited by 18

Association Analysis of Krüppel-Like Factor 11 Variants with Type 2 Diabetes in Pima Indians

Ma, L., Hanson, R. L., Que, L. N., Mack, J. L., Franks, P. W., Infante, A. M., Kobes, S., Bogardus, C., & Baier, L. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0546 · Cited by 14

Regulation of Angiotensin II-Induced Krueppel-Like Factor 5 Expression in Vascular Smooth Muscle Cells

Gao, D., Niu, X., Ning, N., & Hao, G. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2004 · Cited by 14

Growth Inhibitory Effect of Krueppel-like Factor 6 on Human Prostatic Carcinoma and Renal Carcinoma Cell Lines

Cheng, X., Li, D., Zhuang, M., Chen, Z.-Y., Lu, D.-X., & Hattori, T. (2008) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.216.35 · Cited by 14

Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias

Buttar, N. S., Fernández-Zapico, M. E., & Urrutia, R. A. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000239864.73962.db · Cited by 13

Genetic Analysis of Krüppel-Like Zinc Finger 11 Variants in 5864 Danish Individuals: Potential Effect on Insulin Resistance and Modified Signal Transducer and Activator of Transcription-3 Binding by Promoter Variant −1659G>C

Gutiérrez‐Aguilar, R., Froguel, P., Hamid, Y. H., Benmezroua, Y., Jørgensen, T., Borch‐Johnsen, K., Hansen, T. F., Pedersen, O. B., & Neve, B. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2504 · Cited by 12

Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation

Siddique, A., Malo, M. S., Ocuin, L. M., Hinnebusch, B. F., Abedrapo, M. A., Henderson, J. W., Zhang, W., Mozumder, M., Yang, V. W., & Hodin, R. A. (2003) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2003.09.006 · Cited by 10

Absence of mutations in the transforming growth factor-β inducible early gene 1, TIEG1, in pancreatic cancer

Antonello, D., Moore, P. S., Zamboni, G., Falconi, M., & Scarpa, A. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00802-3 · Cited by 10

Cell Growth Inhibition by Okadaic Acid Involves Gut-Enriched Kruppel-like Factor–Mediated Enhanced Expression of c-Myc

Zhang, L., Wali, A., Ramana, C. V., & Rishi, A. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2505 · Cited by 8

Krüppel-like factor 4 (KLF4): What we currently know

Ghaleb, A. M., & Yang, V. W. (2017) · Gene · doi:10.1016/j.gene.2017.02.025 · Cited by 523

A single-cell atlas of chromatin accessibility in the human genome

Zhang, K., Hocker, J. D., Miller, M., Hou, X., Chiou, J., Poirion, O. B., Qiu, Y., Li, Y. E., Gaulton, K. J., Wang, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.024 · Cited by 502

Transcriptional Control of Dendritic Cell Development

Murphy, T. L., Grajales-Reyes, G. E., Wu, X., Tussiwand, R., Briseño, C. G., Iwata, A., Kretzer, N. M., Durai, V., & Murphy, K. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120204 · Cited by 489

Krüppel-like factors in cancer

Tetreault, M.-P., Yang, Y., & Katz, J. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3582 · Cited by 398

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Bis, J. C., Jian, X., Kunkle, B. W., Chen, Y., Hamilton-Nelson, K. L., Bush, W. S., Salerno, W. J., Lancour, D., Ma, Y., Renton, A. E., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0112-7 · Cited by 248