Mammalian Krüppel-Like Factors in Health and Diseases

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N., Lei, K.-J., Li, L., Marinos, N., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,699

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., & Clevers, H. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 2,905

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., & Yamanaka, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1374 · Cited by 2,380

Adipocytes as regulators of energy balance and glucose homeostasis

Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170

PLEIOTROPIC EFFECTS OF STATINS

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Transcriptional regulation of adipogenesis

Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,898

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

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miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

Cordes, K. R., Sheehy, N. T., White, M. P., Berry, E. C., Morton, S. U., Muth, A. N., Lee, T.-H., Miano, J. M., Ivey, K. N., & Srivastava, D. (2009) · Nature · doi:10.1038/nature08195 · Cited by 1,585

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

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An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

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An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells

Kim, J., Chu, J., Shen, X., Wang, J., & Orkin, S. H. (2008) · Cell · doi:10.1016/j.cell.2008.02.039 · Cited by 1,332

Molecular Regulation of Adipogenesis

Rosen, E. D., & Spiegelman, B. M. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.145 · Cited by 1,285

Homing and cellular traffic in lymph nodes

von Andrian, U. H., & Mempel, T. R. (2003) · Nature Reviews Immunology · doi:10.1038/nri1222 · Cited by 1,281

Control of endodermal endocrine development by Hes-1

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Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

Molkentin, J. D., Lin, Q., Duncan, S. A., & Olson, E. N. (1997) · Genes & Development · doi:10.1101/gad.11.8.1061 · Cited by 1,150

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

Fantini, M. C., Becker, C., Monteleone, G., Pallone, F., Galle, P. R., & Neurath, M. F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5149 · Cited by 1,135

Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Androgen-Independent Prostate Cancer

Stanbrough, M., Bubley, G. J., Ross, K., Golub, T. R., Rubin, M. A., Penning, T. M., Febbo, P. G., & Balk, S. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4000 · Cited by 1,082

Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer

Black, A. R., Black, J. D., & Azizkhan‐Clifford, J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1111 · Cited by 1,049

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

Fontenot, J. D., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1179 · Cited by 950

Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

Orkin, S. H., Kazazian, H. H., Antonarakis, S. E., Goff, S. C., Boehm, C. D., Sexton, J. P., Waber, P. G., & Giardina, P. J. V. (1982) · Nature · doi:10.1038/296627a0 · Cited by 926

Myofibroblasts. I. Paracrine cells important in health and disease

Powell, D. W., Mifflin, R. C., Valentich, J. D., Crowe, S. E., Saada, J. I., & West, A. B. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.1.c1 · Cited by 924

Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms

Jain, M. K., & Ridker, P. M. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1901 · Cited by 915

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

Shi, Y., Desponts, C., Do, J. T., Hahm, H. S., Schöler, H. R., & Ding, S. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.10.004 · Cited by 902

The emerging complexity of protein ubiquitination

Komander, D. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370937 · Cited by 821

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

Li, M. O., Sanjabi, S., & Flavell, R. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.011 · Cited by 805

The role of epithelial-mesenchymal transition in cancer pathology

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Klf4 is a transcription factor required for establishing the barrier function of the skin

Segre, J. A., Bauer, C., & Fuchs, E. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 788

A core Klf circuitry regulates self-renewal of embryonic stem cells

Jiang, J., Chan, Y.-S., Loh, Y.-H., Cai, J., Tong, G.-Q., Lim, C.-A., Robson, P., Zhong, S., & Ng, H.-H. (2008) · Nature Cell Biology · doi:10.1038/ncb1698 · Cited by 751

Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells

Yamanaka, S. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.05.012 · Cited by 740

A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.

Miller, I. J., & Bieker, J. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2776 · Cited by 723

KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation

SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 723

KLF Family Members Regulate Intrinsic Axon Regeneration Ability

Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J. L., Lemmon, V. P., & Goldberg, J. L. (2009) · Science · doi:10.1126/science.1175737 · Cited by 714

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 701

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)

Dekker, R. J., van Soest, S., Fontijn, R. D., Salamanca, S., de Groot, P. G., VanBavel, E., Pannekoek, H., & Horrevoets, A. J. G. (2002) · Blood · doi:10.1182/blood-2002-01-0046 · Cited by 692

Self-Renewal and Cancer of the Gut: Two Sides of a Coin

Radtke, F., & Clevers, H. (2005) · Science · doi:10.1126/science.1104815 · Cited by 690

Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

Makowski, L., Boord, J. B., Maeda, K., Babaev, V. R., Uysal, K. T., Morgan, M. A., Parker, R. A., Suttles, J., Fazio, S., Hotamisligil, G. S., et al. (2001) · Nature Medicine · doi:10.1038/89076 · Cited by 686

Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation

Smas, C. M., & Sul, H. S. (1993) · Cell · doi:10.1016/0092-8674(93)90252-l · Cited by 680

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature

Dai, G., Kaazempur-Mofrad, M. R., Natarajan, S., Zhang, Y., Vaughn, S., Blackman, B. R., Kamm, R. D., García-Cardeña, G., & Gimbrone, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406073101 · Cited by 664

MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation

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Identification and Characterization of a Gene Encoding a Gut-enriched Krüppel-like Factor Expressed during Growth Arrest

Shields, J. M., Christy, R. J., & Yang, V. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.20009 · Cited by 652

The intestinal stem cell

Barker, N., van de Wetering, M., & Clevers, H. (2008) · Genes & Development · doi:10.1101/gad.1674008 · Cited by 629

Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

Parkins, A. C., Sharpe, A. H., & Orkin, S. H. (1995) · Nature · doi:10.1038/375318a0 · Cited by 603

Transcriptional regulation of erythropoiesis: an affair involving multiple partners

Cantor, A. B., & Orkin, S. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205326 · Cited by 594

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon

Katz, J. P., Perreault, N., Goldstein, B. G., Lee, C. S., Labosky, P. A., Yang, V. W., & Kaestner, K. H. (2002) · Development · doi:10.1242/dev.129.11.2619 · Cited by 594

Kruppel-like factor 2 regulates thymocyte and T-cell migration

Carlson, C. M., Endrizzi, B. T., Wu, J., Ding, X., Weinreich, M. A., Walsh, E. R., Wani, M. A., Lingrel, J. B., Hogquist, K. A., & Jameson, S. C. (2006) · Nature · doi:10.1038/nature04882 · Cited by 593

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

Rowland, B. D., Bernards, R., & Peeper, D. S. (2005) · Nature Cell Biology · doi:10.1038/ncb1314 · Cited by 590

Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome

Wilkinson, K. D. (2000) · Seminars in Cell & Developmental Biology · doi:10.1006/scdb.2000.0164 · Cited by 569

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

Nuez, B., Michalovich, D., Bygrave, A., Ploemacher, R., & Grosveld, F. (1995) · Nature · doi:10.1038/375316a0 · Cited by 551

KLF4, p21 and context-dependent opposing forces in cancer

Rowland, B. D., & Peeper, D. S. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1780 · Cited by 551

Sp transcription factor family and its role in cancer

Safe, S., & Abdelrahim, M. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.006 · Cited by 500

Functional selectivity of recombinant mammalian SWI/SNF subunits

Kadam, S., McAlpine, G. S., Phelan, M. L., Kingston, R. E., Jones, K. A., & Emerson, B. M. (2000) · Genes & Development · doi:10.1101/gad.828000 · Cited by 497

Gene expression profiling predicts clinical outcome of prostate cancer

Glinsky, G. V., Glinskii, A. B., Stephenson, A. J., Hoffman, R. M., & Gerald, W. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20032 · Cited by 479

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

Oishi, Y., Manabe, I., Tobe, K., Tsushima, K., Shindo, T., Fujiu, K., Nishimura, G., Maemura, K., Yamauchi, T., Kubota, N., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.005 · Cited by 459

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

Real, P. J., Tosello, V., Palomero, T., Castillo, M., Hernando, E., de Stanchina, E., Sulis, M. L., Barnes, K., Sawai, C., Homminga, I., et al. (2009) · Nature Medicine · doi:10.1038/nm.1900 · Cited by 445

CTGF Expression is Induced by TGF- β in Cardiac Fibroblasts and Cardiac Myocytes: a Potential Role in Heart Fibrosis

Chen, M. M., Lam, A., Abraham, J. A., Schreiner, G. F., & Joly, A. H. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1215 · Cited by 442

KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer

Narla, G., Heath, K. E., Reeves, H. L., Li, D., Giono, L. E., Kimmelman, A. C., Glucksman, M. J., Narla, J., Eng, F. J., Chan, A. M., et al. (2001) · Science · doi:10.1126/science.1066326 · Cited by 442

Role of Krüppel-Like Transcription Factors in Endothelial Biology

Atkins, G. B., & Jain, M. K. (2007) · Circulation Research · doi:10.1161/01.res.0000267856.00713.0a · Cited by 419

LKLF: A Transcriptional Regulator of Single-Positive T Cell Quiescence and Survival

Kuo, C. T., Veselits, M. L., & Leiden, J. M. (1997) · Science · doi:10.1126/science.277.5334.1986 · Cited by 419

GATA transcription factors in the developing and adult heart

PIKKARAINEN, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.025 · Cited by 416

Current View: Intestinal Stem Cells and Signaling

Scoville, D. H., Sato, T., He, X. C., & Li, L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.079 · Cited by 416

A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

Schuh, R., Aicher, W., Gaul, U., Côte, S., Preiss, A., Maier, D., Seifert, E., Nauber, U., Schröder, C., Kemler, R., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90817-2 · Cited by 410

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling

Shindo, T., Manabe, I., Fukushima, Y., Tobe, K., Aizawa, K., Miyamoto, S., Kawai-Kowase, K., Moriyama, N., Imai, Y., Kawakami, H., et al. (2002) · Nature Medicine · doi:10.1038/nm738 · Cited by 394

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Sinclair, L. V., Finlay, D., Feijoo, C., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H., & Cantrell, D. A. (2008) · Nature Immunology · doi:10.1038/ni.1603 · Cited by 390

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

Takeda, N., Manabe, I., Uchino, Y., Eguchi, K., Matsumoto, S., Nishimura, S., Shindo, T., Sano, M., Otsu, K., Snider, P., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40295 · Cited by 389

Kruppel-Like Factor 2 (KLF2) Regulates Endothelial Thrombotic Function

Lin, Z., Kumar, A., SenBanerjee, S., Staniszewski, K., Parmar, K., Vaughan, D. E., Gimbrone, M. A., Balasubramanian, V., García-Cardeña, G., & Jain, M. K. (2005) · Circulation Research · doi:10.1161/01.res.0000159707.05637.a1 · Cited by 385

DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells

McCormick, S. M., Eskin, S. G., McIntire, L. V., Teng, C. L., Lu, C.-M., Russell, C. G., & Chittur, K. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171259298 · Cited by 385

Oct4 and LIF/Stat3 Additively Induce Krüppel Factors to Sustain Embryonic Stem Cell Self-Renewal

Hall, J., Guo, G., Wray, J., Eyres, I., Nichols, J., Grotewold, L., Morfopoulou, S., Humphreys, P., Mansfield, W., Walker, R., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.11.003 · Cited by 383

Krüppel-like transcription factors: A functional family

Pearson, R., Fleetwood, J., Eaton, S., Crossley, M., & Bao, S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.07.018 · Cited by 379

Kruppel-like Factor 4 Regulates Endothelial Inflammation

Hamik, A., Lin, Z., Kumar, A., Balcells, M., Sinha, S., Katz, J., Feinberg, M. W., Gerszten, R. E., Edelman, E. R., & Jain, M. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700078200 · Cited by 379

Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia

Hart, A., Melet, F., Grossfeld, P., Chien, K., Jones, C., Tunnacliffe, A., Favier, R., & Bernstein, A. (2000) · Immunity · doi:10.1016/s1074-7613(00)00017-0 · Cited by 369

The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis

Kuo, C. T., Veselits, M. L., Barton, K. P., Lu, M. M., Clendenin, C., & Leiden, J. M. (1997) · Genes & Development · doi:10.1101/gad.11.22.2996 · Cited by 369

Kruppel-like Factor 4 Abrogates Myocardin-induced Activation of Smooth Muscle Gene Expression

Liu, Y., Sinha, S., McDonald, O. G., Shang, Y., Hoofnagle, M. H., & Owens, G. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412862200 · Cited by 362

Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcome

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Powell, D. W. et al. Myofibroblasts. I. Paracrine cells important in health and disease. Am. J. Physiol. 277, C1-C9

Powell, D. W., Mifflin, R. C., Valentich, J. D., Crowe, S. E., Saada, J. I., & Ab, W. (1999) · Cited by 358

Sin Meets NuRD and Other Tails of Repression

Knoepfler, P. S., & Eisenman, R. N. (1999) · Cell · doi:10.1016/s0092-8674(00)81531-7 · Cited by 356

Endothelial KLF2 Links Local Arterial Shear Stress Levels to the Expression of Vascular Tone-Regulating Genes

Dekker, R. J., van Thienen, J. V., Rohlena, J., de Jager, S. C., Elderkamp, Y. W., Seppen, J., de Vries, C. J. M., Biessen, E. A. L., van Berkel, T. J. C., Pannekoek, H., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63002-7 · Cited by 355

Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells

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KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium

Dekker, R. J., Boon, R. A., Rondaij, M. G., Kragt, A., Volger, O. L., Elderkamp, Y. W., Meijers, J. C. M., Voorberg, J., Pannekoek, H., & Horrevoets, A. J. G. (2006) · Blood · doi:10.1182/blood-2005-08-3465 · Cited by 353

Transcriptional Regulation of Adipogenesis by KLF4

Birsoy, K., Chen, Z., & Friedman, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.001 · Cited by 345

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

Zhang, W., & Bieker, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9855 · Cited by 342

Role of Krüppel-like Factor 15 (KLF15) in Transcriptional Regulation of Adipogenesis

Mori, T., Sakaue, H., Iguchi, H., Gomi, H., Okada, Y., Takashima, Y., Nakamura, K., Nakamura, T., Yamauchi, T., Kubota, N., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410515200 · Cited by 340

The Kruppel‐like factor KLF4 is a critical regulator of monocyte differentiation

Feinberg, M. W., Wara, A. K., Cao, Z., Lebedeva, M. A., Rosenbauer, F., Iwasaki, H., Hirai, H., Katz, J. P., Haspel, R. L., Gray, S., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601824 · Cited by 337

Non-lipid-related effects of statins

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New common variants affecting susceptibility to basal cell carcinoma

Stacey, S. N., Sulem, P., Masson, G., Gudjonsson, S. A., Thorleifsson, G., Jakobsdottir, M., Sigurdsson, A., Gudbjartsson, D. F., Sigurgeirsson, B., Benediktsdottir, K. R., et al. (2009) · Nature Genetics · doi:10.1038/ng.412 · Cited by 328

The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter

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A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.

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Krüppel-like factor 5 Is Essential for Blastocyst Development and the Normal Self-Renewal of Mouse ESCs

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Krüppel-Like Factor 8 Induces Epithelial to Mesenchymal Transition and Epithelial Cell Invasion

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Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity

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The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability

Drissen, R., von Lindern, M., Kolbus, A., Driegen, S., Steinlein, P., Beug, H., Grosveld, F., & Philipsen, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5205-5214.2005 · Cited by 168

Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread

Narla, G., DiFeo, A., Yao, S., Banno, A., Hod, E., Reeves, H. L., Qiao, R. F., Camacho-Vanegas, O., Levine, A., Kirschenbaum, A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0217 · Cited by 166

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is Due to Inhibition of MEF2 by NF-κB and Histone Deacetylases

Kumar, A., Lin, Z., SenBanerjee, S., & Jain, M. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.5893-5903.2005 · Cited by 165

A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells

Conkright, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.5.1263 · Cited by 161

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ

Oishi, Y., Manabe, I., Tobe, K., Ohsugi, M., Kubota, T., Fujiu, K., Maemura, K., Kubota, N., Kadowaki, T., & Nagai, R. (2008) · Nature Medicine · doi:10.1038/nm1756 · Cited by 160

Human Kruppel-like Factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription

Vliet, J. V., Turner, J., & Crossley, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.9.1955 · Cited by 158

Functional Cross-Antagonism between Transcription Factors FLI-1 and EKLF

Starck, J., Cohet, N., Gonnet, C., Sarrazin, S., Doubeikovskaia, Z., Doubeikovski, A., Verger, A., Duterque‐Coquillaud, M., & Morlé, F. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1390-1402.2003 · Cited by 158

Klf5 is involved in self-renewal of mouse embryonic stem cells

Parisi, S., Passaro, F., Aloia, L., Manabe, I., Nagai, R., Pastore, L., & Russo, T. (2008) · Journal of Cell Science · doi:10.1242/jcs.027599 · Cited by 156

Human Kruppel-like Factor 5 Is a Target of the E3 Ubiquitin Ligase WWP1 for Proteolysis in Epithelial Cells

Chen, C., Sun, X., Guo, P., Dong, X., Sethi, P., Cheng, X., Zhou, J., Ling, J., Simons, J. W., Lingrel, J. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506183200 · Cited by 155

Novel role for EKLF in megakaryocyte lineage commitment

Frontelo, P., Manwani, D. G., Galdass, M., Karsunky, H., Lohmann, F., Gallagher, P. G., & Bieker, J. J. (2007) · Blood · doi:10.1182/blood-2007-03-082065 · Cited by 155

Krüppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis

Scobie, K. N., Hall, B. J., Wilke, S. A., Klemenhagen, K. C., Fujii‐Kuriyama, Y., Ghosh, A., Hen, R., & Sahay, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2260-09.2009 · Cited by 154

Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor Protein through Interaction with Cyclin D1

Benzeno, S., Narla, G., Allina, J., Cheng, G. Z., Reeves, H. L., Banck, M. S., Odin, J. A., Diehl, J. A., Germain, D., & Friedman, S. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2818 · Cited by 154

Megakaryocyte biology and related disorders

Pang, L., Weiss, M. J., & Poncz, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26720 · Cited by 154

Intestinal-enriched Krüppel-like Factor (Krüppel-like Factor 5) Is a Positive Regulator of Cellular Proliferation

Sun, R., Chen, X., & Yang, V. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000870200 · Cited by 151

Transcription Factor KLF7 Is Important for Neuronal Morphogenesis in Selected Regions of the Nervous System

Laub, F., Lei, L., Sumiyoshi, H., Kajimura, D., Dragomir, C. L., Smaldone, S., Puché, A. C., Petros, T. J., Mason, C. A., Parada, L. F., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5699-5711.2005 · Cited by 151

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2

Fledderus, J. O., van Thienen, J. V., Boon, R. A., Dekker, R. J., Rohlena, J., Volger, O. L., Bijnens, A. P., Daemen, M. J. A. P., Kuiper, J., van Berkel, T. J. C., et al. (2007) · Blood · doi:10.1182/blood-2006-07-036020 · Cited by 150

A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer

Chen, C., Bhalala, H. V., Qiao, H., & Dong, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205817 · Cited by 146

Krüppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids

Yoshida, T., Gan, Q., & Owens, G. K. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00288.2008 · Cited by 146

Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC.

Orkin, S. H., Antonarakis, S. E., & Kazazian, H. H. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)47203-6 · Cited by 145

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.

Perkins, A. C., Gaensler, K. M. L., & Orkin, S. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12267 · Cited by 145

KLF5 promotes cell proliferation and tumorigenesis through gene regulationin the TSU-Pr1 human bladder cancer cell line

Chen, C., Benjamin, M. S., Sun, X., Otto, K. B., Guo, P., Dong, X., Bao, Y., Zhou, Z., Cheng, X., Simons, J. W., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21533 · Cited by 145

The human β‐globin locus control region: A center of attraction

Levings, P. P., & Bungert, J. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2002.02797.x · Cited by 144

Developmental regulation of yolk sac hematopoiesis by Krüppel-like factor 6

Matsumoto, N., Kubo, A., Liu, H., Akita, K., Laub, F., Ramirez, F., Keller, G. M., & Friedman, S. L. (2005) · Blood · doi:10.1182/blood-2005-05-1916 · Cited by 142

MicroRNA Expression in Human Airway Smooth Muscle Cells

Kuhn, A. R., Schlauch, K. A., Lao, R., Halayko, A. J., Gerthoffer, W. T., & Singer, C. A. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0123oc · Cited by 142

Kruppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells

Wei, D., Kanai, M., Jia, Z., Le, X., & Xie, K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5953 · Cited by 142

The role of KLF6 and its splice variants in cancer therapy

DiFeo, A. V., Martignetti, J. A., & Narla, G. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.11.001 · Cited by 141

Frequent inactivation of the tumor suppressor Kruppel-like factor 6 ( KLF6 ) in hepatocellular carcinoma

Kremer-Tal, S., Reeves, H. L., Narla, G., Thung, S. N., Schwartz, M., DiFeo, A. V., Katz, A. M., Bruix, J., Bioulac‐Sage, P., Martignetti, J. A., et al. (2004) · Hepatology · doi:10.1002/hep.20460 · Cited by 141

KLF6 Induces Apoptosis in Prostate Cancer Cells through Up-regulation of ATF3

Huang, X., Li, X., & Guo, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802515200 · Cited by 140

Novel Cross Talk of Krüppel-Like Factor 4 and β-Catenin Regulates Normal Intestinal Homeostasis and Tumor Repression

Zhang, W., Chen, X., Kato, Y., Evans, P. M., Yuan, S., Yang, J., Rychahou, P. G., Yang, V. W., He, X., Evers, B. M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2055-2064.2006 · Cited by 140

Expression of the Transcription Factor Lung Kruppel-Like Factor Is Regulated by Cytokines and Correlates with Survival of Memory T Cells In Vitro and In Vivo

Schober, S. L., Kuo, C. T., Schluns, K. S., Lefrançois, L., Leiden, J. M., & Jameson, S. C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3662 · Cited by 139

Krüppel-like factor 4 (KLF4): What we currently know

Ghaleb, A. M., & Yang, V. W. (2017) · Gene · doi:10.1016/j.gene.2017.02.025 · Cited by 523

A single-cell atlas of chromatin accessibility in the human genome

Zhang, K., Hocker, J. D., Miller, M., Hou, X., Chiou, J., Poirion, O. B., Qiu, Y., Li, Y. E., Gaulton, K. J., Wang, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.024 · Cited by 502

Transcriptional Control of Dendritic Cell Development

Murphy, T. L., Grajales-Reyes, G. E., Wu, X., Tussiwand, R., Briseño, C. G., Iwata, A., Kretzer, N. M., Durai, V., & Murphy, K. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120204 · Cited by 489

Krüppel-like factors in cancer

Tetreault, M.-P., Yang, Y., & Katz, J. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3582 · Cited by 398

Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation

Bis, J. C., Jian, X., Kunkle, B. W., Chen, Y., Hamilton-Nelson, K. L., Bush, W. S., Salerno, W. J., Lancour, D., Ma, Y., Renton, A. E., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0112-7 · Cited by 248