Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced Hypertension
Open accessAbstract
L ong-term high salt intake increases the risk for hyper- tension and associated cardiovascular and kidney disease, whereas modest reductions in salt intake significantly decrease blood pressure (BP) in many hypertensive subjects.[1][2][3] However, the mechanisms of salt-induced changes in BP continue to be the subject of considerable interest and controversy.
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Individuals who gain excess adiposity maintain sodium balance at higher blood pressures than when they were lean, indicating impaired renal-pressure natriuresis.
“individuals who gain excess adiposity maintain sodium balance at higher BPs than when they were lean, indicating impaired renal-pressure natriuresis16,51.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [51]
Mild elevations in angiotensin II levels in obesity are driven largely by increased renal renin secretion due to sympathetic nervous system activation, kidney compression, and other factors such as adipokines.
“Current evidence suggests that mild elevations in AngII levels in obesity are driven largely by increased renal renin secretion due to SNS activation, kidney compression and perhaps other factors such as adipokines51,60.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [51]
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HumMod: a modeling environment for the simulation of integrative human physiology
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T helper cell polarity determines salt sensitivity and hypertension development
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Salt sensitivity of blood pressure. From renal mechanisms to immune and inflammatory pathways
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- Authors
- Hall, J. E.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Hall, John E.
- ORCID
- Hall, John E.
- Venue
- Circulation
- Published
- 2016-03
- Volume
- 133
- Issue
- 9
- Pages
- 894-906
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC5009905
- OpenAlex
- W2289208127
- Semantic Scholar
- 6e62d9fd020148ebbd95f4d10a255872ab22da90
- Cited by
- 152
- References
- 103
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 27 · 2022: 11 · 2021: 16 · 2020: 20 · 2019: 15 · 2018: 12 · 2017: 19 · 2016: 9
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (GM104357, HL-51971)
- National Heart, Lung, and Blood Institute (HL‐51971, P01HL051971, GM104357)
- National Institute of General Medical Sciences (GM104357, HL51971, P20GM104357)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- salt-induced hypertension, renal dysfunction, high-salt diet, blood pressure regulation, sodium intake, kidney disease, cardiovascular risk
- MeSH terms
- Animals, Humans, Hypertension, Kidney Diseases, Vasodilation, Sodium Chloride, Dietary
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