Mechanism of glucose-induced insulin secretion.
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In human islets, insulin secretion is detectable at glucose concentrations as low as 3 mM, significantly lower than the secretion threshold in mouse islets (~5 mM).
“In human islets, insulin secretion is detectable at glucose concentrations as low as 3 mM (89, 150, 266), which is significantly lower than the secretion threshold in mouse islets (~5 mM (257)).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [257]
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Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
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Rorsman, P., & Braun, M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183754 · Cited by 599 · see citing works
Hypothalamic sensing of fatty acids
Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478 · see citing works
Lambillotte, C., Gilon, P., & Henquin, J. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119175 · Cited by 419 · see citing works
Detimary, P., Dejonghe, S., Ling, Z., Pipeleers, D., Schuit, F., & Henquin, J.-C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33905 · Cited by 159 · see citing works
Insulin Resistance and<i>β</i>-Cell Dysfunction in Aging: The Importance of Dietary Carbohydrate*
CHEN, M., BERGMAN, R. N., & PORTE, D. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-5-951 · Cited by 155 · see citing works
The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Heimberg, H., De Vos, A., Moens, K., Quartier, E., Bouwens, L., Pipeleers, D., Van Schaftingen, E., Madsen, O., & Schuit, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7036 · Cited by 142 · see citing works
Hjortoe, G. M., Hagel, G. M., Terry, B. R., Thastrup, O., & Arkhammar, P. O. G. (2004) · Acta Diabetologica · doi:10.1007/s00592-004-0164-9 · Cited by 28 · see citing works
- Authors
- Hedeskov, C. J.
- Corresponding author
- Hedeskov, C J
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1980-04
- Volume
- 60
- Issue
- 2
- Pages
- 442-509
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2273325308
- Cited by
- 435
- References
- 0
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 2 · 2012: 8
- FWCI
- 27.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- glucose, insulin secretion, pancreatic beta cells, glucose signaling
- MeSH terms
- Insulin Secretion, Cyclic AMP, Adenosine Triphosphate, Adenylyl Cyclases, Animals, Blood Glucose, Calcium, Carbohydrates, Cell Membrane Permeability, Cytoplasmic Granules, Dogs, Electrophysiology, Endocytosis, Exocytosis, Glucose, Cricetinae, Insulin, Islets of Langerhans, Kinetics, Membrane Potentials, Methods, Models, Biological, Mice, Rats, In Vitro Techniques
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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